Lepirudin
Lepirudin is an anticoagulant that functions as a direct thrombin inhibitor.
Brand name: Refludan, Generic: Lepirudin rDNA for injection.
Lepirudin is a recombinant hirudin derived from yeast cells. It is almost identical to hirudin extracted from Hirudo medicinalis. It differs by the substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63.
Lepirudin may be used as an anticoagulant when heparins (unfractionated or low-molecular-weight) are contraindicated because of heparin-induced thrombocytopenia.
Market withdrawal
Bayer announced that it ceased the production of lepirudin (Refludan) on May 31, 2012. At the time of the announcement, the company expected that supply from wholesalers was going to be depleted by mid-2013.
References
External links
Podcasts:
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by Lou Pardini
What Might Have Been
by: Lou PardiniSomewhere, lost in the wind
I'm watching you
Sunlight touching your hair
And I remember
Somehow, we said that we would never stray
But somehow we lost our way
Promises too often spoken
Are easily broken apart
I'm ready this time
I know that I'm no longer undecided
Don't wanna be
A fool wondering what might have been
Trace of forever lingering
Drawing me closer to you
A new beginning
Now I know
There is no doubt I understand
Just how fragile love can be
I can't forget
Your mem'ry found me
Now I know where I belong
I'm ready this time
I know that I'm no longer undecided
Don't wanna be a fool wondering
What might have been
Through every day, into the night
With only love to guide us
I'm ready to go, coz I've got to know
What might have been
Let the lovin' decide, I can't run, I can't hide
I want you to know
My heart will show that I'm ready this time
I know that I'm no longer undecided
Don't wanna be, a fool wondering what might have been
I've searched everywhere, and nothing compares
When we've got love to guide us
I'm ready to go, coz I wanna know what might have been
I'm wondering what might have been
We're gonna find what might have been