A bubble chamber is a vessel filled with a superheated transparent liquid (most often liquid hydrogen) used to detect electrically charged particles moving through it. It was invented in 1952 by Donald A. Glaser, for which he was awarded the 1960 Nobel Prize in Physics. Supposedly, Glaser was inspired by the bubbles in a glass of beer; however, in a 2006 talk, he refuted this story, saying that although beer was not the inspiration for the bubble chamber, he did experiments using beer to fill early prototypes.

Cloud chambers work on the same principles as bubble chambers, only they are based on supersaturated vapor rather than superheated liquid. While bubble chambers were extensively used in the past, they have now mostly been supplanted by wire chambers and spark chambers. Historically, notable bubble chambers include the Big European Bubble Chamber (BEBC) and Gargamelle.

The bubble chamber is similar to a cloud chamber in application and basic principle. It is normally made by filling a large cylinder with a liquid heated to just below its boiling point. As particles enter the chamber, a piston suddenly decreases its pressure, and the liquid enters into a superheated, metastable phase. Charged particles create an ionisation track, around which the liquid vaporises, forming microscopic bubbles. Bubble density around a track is proportional to a particle's energy loss.