Wrch1
RhoU (or Wrch1 or Chp2) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rho family of GTPases. Wrch1 was identified in 2001 as encoded by a non-canonical Wnt induced gene. RhoU/Wrch delineates with RhoV/Chp a Rho subclass related to Rac and Cdc42, which emerged in early multicellular organisms during evolution.
Model organisms
Model organisms have been used in the study of RhoU function. A conditional knockout mouse line, called Rhoutm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on mutant mice, but no significant abnormalities were observed.
References
Podcasts:
Top Of The World
Heavily Father, forgive us for we are sayin'
Yeahhh, I just got it
Come on, yaa, Rich Boy
[Chorus:]
You're on the top of the world
... Keep so calling me
Don't goo
To the top of
... first hit in the hood roll...
Real... Hold me tight
... still big advice
The old school is still...
Getting to the super bowl... lady
... first in the universe
Only...
I'm just trying make the worse
... going in Alabama so that just ain't got bare with me
River see the time when my neck got...
Try to... can't be regret it... kiss me... let's go
[Chorus]
On the top of the world
You keep so calling me
So I can ohhh
To the top of the world...
Ohhhh
To the top of the world
Lady to the top...
Witness we make history
... have been thousands of blue...
... Credit school...
... but I'm still determinate
Doing... I need to be exterminated
Listen to my first album, told you... when I feel
Do this for my brother and my uncle
Do it twenty years, came nobody to take my fly
... can't stop...
[Chorus]
We got to keep it moving
Ha, ha ha haha
I see you...
And this is just a previous
To the top of the world... keep calling me