Lewiston is a city in Androscoggin County in Maine, and the second-largest city in the state. The population was 41,592 at the 2010 census. It is one of two principal cities of and included within the Lewiston-Auburn, Maine metropolitan New England city and town area and the Lewiston-Auburn, Maine metropolitan statistical area, which as of 2006 census estimates has a combined population of 107,552. It is also part of the extended Portland-Lewiston-South Portland, Maine combined statistical area, which has a combined population 621,219 as of 2006 estimates.

A former industrial center, it is located in south-central Maine, at the falls of the Androscoggin River, across from Auburn. Lewiston and Auburn are often considered a single entity and referred to as Lewiston–Auburn, which is colloquially abbreviated as L-A or L/A, and have a combined population of 59,647 people. Together, Lewiston-Auburn is somewhat smaller than Maine's largest city, Portland (excluding its own suburbs). Lewiston is home to Bates College, the Basilica of Saints Peter and Paul, the University of Southern Maine's Lewiston-Auburn College, and two significant regional general hospitals: Central Maine Medical Center and Saint Mary's Regional Medical Center.

Maine (ⁱ/ˈmeɪn/) is a state in the New England region of the northeastern United States, bordered by the Atlantic Ocean to the east and south, New Hampshire to the west, and the Canadian provinces of Quebec to the northwest and New Brunswick to the northeast. Maine is both the northernmost and easternmost portion of New England. It is known for its scenery—its jagged, mostly rocky coastline, its low, rolling mountains, its heavily forested interior and picturesque waterways—as well as for its seafood cuisine, especially lobsters and clams.

For thousands of years, indigenous peoples were the only inhabitants of the territory that is now Maine. At the time of European encounter, several Algonquian-speaking peoples inhabited the area. The first European settlement in Maine was by the French in 1604 on Saint Croix Island, by Pierre Dugua, Sieur de Mons. The first English settlement in Maine, the short-lived Popham Colony, was established by the Plymouth Company in 1607. A number of English settlements were established along the coast of Maine in the 1620s, although the rugged climate, deprivations, and conflict with the local peoples caused many to fail over the years. As Maine entered the 18th century, only a half dozen European settlements survived. Patriot and British forces contended for Maine's territory during the American Revolution and the War of 1812. Maine was part of the Commonwealth of Massachusetts until 1820, when it voted to secede from Massachusetts. On March 15, 1820, it was admitted to the Union as the 23rd state under the Missouri Compromise. Maine is the 39th most extensive and the 41st most populous of the 50 United States.