Myriandrus (or Myriandros) was an ancient Phoenician town and seaport located near the modern city of İskenderun, Turkey.

In 333 BC Alexander the Great intended to lay an ambush at Myriandrus of Darius III of Persia but in the end the battle took place near Issus.

Coordinates: 36°35′N 36°10′E / 36.583°N 36.167°E / 36.583; 36.167

Alexander III of Macedon (20/21 July 356 – 10/11 June 323 BC), commonly known as Alexander the Great (Greek: Ἀλέξανδρος ὁ Μέγας, Aléxandros ho Mégas from the Greek αλέξω alexo "to defend, help" + ανήρ aner "man"), was a king of Macedon, a state in northern ancient Greece. Born in Pella in 356 BC, Alexander was tutored by Aristotle until the age of 16. By the age of thirty, he had created one of the largest empires of the ancient world, stretching from the Ionian Sea to the Himalayas. He was undefeated in battle and is considered one of history's most successful commanders.

Alexander succeeded his father, Philip II of Macedon, to the throne in 336 BC after Philip was assassinated. Upon Philip's death, Alexander inherited a strong kingdom and an experienced army. He was awarded the generalship of Greece and used this authority to launch his father's military expansion plans. In 334 BC, he invaded Persian-ruled Asia Minor and began a series of campaigns that lasted ten years. Alexander broke the power of Persia in a series of decisive battles, most notably the battles of Issus and Gaugamela. He subsequently overthrew the Persian King Darius III and conquered the entirety of the Persian Empire. At that point, his empire stretched from the Adriatic Sea to the Indus River.