- published: 09 May 2011
- views: 340
Create your page here
Tuesday, 27 September 2016
back to playlist
Why does toothpaste, chewing gum and peppermint feel cold? These products are no colder than the ambient temperature around us, but they contain a chemical called L-menthol that tricks our body's TRPM8 temperature receptors. This is why mint tastes cold, and why minty products make cold things feel even colder.
Some music by:
X I X X: https://soundcloud.com/jeff-kaale
- published: 14 Jun 2016
- views: 39
TRPM8 is a neuronal osmosensor that regulates eye blinking in mice. Talisia Quallo et al (2015), Nature Communications http://dx.doi.org/10.1038/ncomms8150
Specific peripheral sensory neurons respond to increases in extracellular osmolality but the mechanism responsible for excitation is unknown. Here we show that small increases in osmolality excite isolated mouse dorsal root ganglion (DRG) and trigeminal ganglion (TG) neurons expressing the cold-sensitive TRPM8 channel (transient receptor potential channel, subfamily M, member 8). Hyperosmotic responses were abolished by TRPM8 antagonists, and were absent in DRG and TG neurons isolated from Trpm8−/− mice. Heterologously expressed TRPM8 was activated by increased osmolality around physiological levels and inhibited by reduced osmolality. Electrophysiological studies in a mouse corneal preparation demonstrated that osmolality regulated the electrical activity of TRPM8-expressing corneal afferent neurons. Finally, the frequency of eye blinks was reduced in Trpm8−/− compared with wild-type mice and topical administration of a TRPM8 antagonist reduced blinking in wild-type mice. Our findings identify TRPM8 as a peripheral osmosensor responsible for the regulation of normal eye-blinking in mice.
- published: 22 May 2015
- views: 53
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8. Debapriya Ghosh et al (2016), Nature Communications http://dx.doi.org/10.1038/ncomms10489
The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although increased functional expression of TRPM8 has been implicated in various forms of pathological cold hypersensitivity, little is known about the cellular and molecular mechanisms that determine TRPM8 abundance at the plasma membrane. Here we demonstrate constitutive transport of TRPM8 towards the plasma membrane in atypical, non-acidic transport vesicles that contain lysosomal-associated membrane protein 1 (LAMP1), and provide evidence that vesicle-associated membrane protein 7 (VAMP7) mediates fusion of these vesicles with the plasma membrane. In line herewith, VAMP7-deficient mice exhibit reduced functional expression of TRPM8 in sensory neurons and concomitant deficits in cold avoidance and icilin-induced cold hypersensitivity. Our results uncover a cellular pathway that controls functional plasma membrane incorporation of a temperature-sensitive TRP channel, and thus regulates thermosensitivity in vivo.
- published: 04 Feb 2016
- views: 27
Video from supplementary material for article "the menthol receptor trpm8 is the principal detector of environmental cold" (http://dx.doi.org/10.1038/nature05910).
- published: 10 Jun 2007
- views: 1200
→Subscribe for new videos every day! http://bit.ly/todayifoundoutsubscribe
→Why Do Superheroes Wear Their Underwear on the Outside?: http://bit.ly/1Ow7J0K
Never run out of things to say at the water cooler with TodayIFoundOut! Brand new videos 7 days a week!
More from TodayIFoundOut
How Did Jeans Become Popular?
http://bit.ly/1Q4MzaB
The Numerous Bodies Recently Found in Ben Franklin’s Basement
http://bit.ly/1jbhjw8
In this video:
Similar to why peppers taste hot, what’s going on here is there is a chemical in mint, menthol, which is tricking the brain into thinking that the area the menthol is applied to is cold; even though in fact, it’s the same as it was before. More specifically, menthol binds with cold-sensitive receptors in your skin; these receptors contain things called “ion channels”, in this case TRPM8. The menthol makes these much more sensitive than normal, so they trigger and you feel a cold sensation, even though everything is more or less the same temperature as before.
Want the text version?: http://www.todayifoundout.com/index.php/2010/08/why-mint-tastes-cold/
Sources:
http://en.wikipedia.org/wiki/Peppermint
http://en.wikipedia.org/wiki/Mentha_spicata
http://en.wikipedia.org/wiki/Mentha
http://en.wikipedia.org/wiki/Menthol
- published: 04 Feb 2016
- views: 2537
- Loading...
-
1:09TRPM8
TRPM8TRPM8
-
3:12WHY TOOTHPASTE FEELS COLD | TRPM8 Receptors Explained
WHY TOOTHPASTE FEELS COLD | TRPM8 Receptors ExplainedWHY TOOTHPASTE FEELS COLD | TRPM8 Receptors Explained
Why does toothpaste, chewing gum and peppermint feel cold? These products are no colder than the ambient temperature around us, but they contain a chemical called L-menthol that tricks our body's TRPM8 temperature receptors. This is why mint tastes cold, and why minty products make cold things feel even colder. Some music by: X I X X: https://soundcloud.com/jeff-kaale -
1:29The path way of trpm8's messages
The path way of trpm8's messagesThe path way of trpm8's messages
-
1:12TRPM8 is a neuronal osmosensor that regulates eye blinking in mice
TRPM8 is a neuronal osmosensor that regulates eye blinking in miceTRPM8 is a neuronal osmosensor that regulates eye blinking in mice
TRPM8 is a neuronal osmosensor that regulates eye blinking in mice. Talisia Quallo et al (2015), Nature Communications http://dx.doi.org/10.1038/ncomms8150 Specific peripheral sensory neurons respond to increases in extracellular osmolality but the mechanism responsible for excitation is unknown. Here we show that small increases in osmolality excite isolated mouse dorsal root ganglion (DRG) and trigeminal ganglion (TG) neurons expressing the cold-sensitive TRPM8 channel (transient receptor potential channel, subfamily M, member 8). Hyperosmotic responses were abolished by TRPM8 antagonists, and were absent in DRG and TG neurons isolated from Trpm8−/− mice. Heterologously expressed TRPM8 was activated by increased osmolality around physiological levels and inhibited by reduced osmolality. Electrophysiological studies in a mouse corneal preparation demonstrated that osmolality regulated the electrical activity of TRPM8-expressing corneal afferent neurons. Finally, the frequency of eye blinks was reduced in Trpm8−/− compared with wild-type mice and topical administration of a TRPM8 antagonist reduced blinking in wild-type mice. Our findings identify TRPM8 as a peripheral osmosensor responsible for the regulation of normal eye-blinking in mice. -
1:06TRPM8-Neuro Polar Plunge 2016
TRPM8-Neuro Polar Plunge 2016TRPM8-Neuro Polar Plunge 2016
-
2:45VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8. Debapriya Ghosh et al (2016), Nature Communications http://dx.doi.org/10.1038/ncomms10489 The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although increased functional expression of TRPM8 has been implicated in various forms of pathological cold hypersensitivity, little is known about the cellular and molecular mechanisms that determine TRPM8 abundance at the plasma membrane. Here we demonstrate constitutive transport of TRPM8 towards the plasma membrane in atypical, non-acidic transport vesicles that contain lysosomal-associated membrane protein 1 (LAMP1), and provide evidence that vesicle-associated membrane protein 7 (VAMP7) mediates fusion of these vesicles with the plasma membrane. In line herewith, VAMP7-deficient mice exhibit reduced functional expression of TRPM8 in sensory neurons and concomitant deficits in cold avoidance and icilin-induced cold hypersensitivity. Our results uncover a cellular pathway that controls functional plasma membrane incorporation of a temperature-sensitive TRP channel, and thus regulates thermosensitivity in vivo. -
0:23Bull sperm motility upon TRPM8 modulation
Bull sperm motility upon TRPM8 modulation -
1:21The path way of trpm8's messages.wmv
The path way of trpm8's messages.wmvThe path way of trpm8's messages.wmv
-
1:01Temperature preference
Temperature preferenceTemperature preference
Video from supplementary material for article "the menthol receptor trpm8 is the principal detector of environmental cold" (http://dx.doi.org/10.1038/nature05910). -
1:21Why Mint Tastes Cold
Why Mint Tastes ColdWhy Mint Tastes Cold
→Subscribe for new videos every day! http://bit.ly/todayifoundoutsubscribe →Why Do Superheroes Wear Their Underwear on the Outside?: http://bit.ly/1Ow7J0K Never run out of things to say at the water cooler with TodayIFoundOut! Brand new videos 7 days a week! More from TodayIFoundOut How Did Jeans Become Popular? http://bit.ly/1Q4MzaB The Numerous Bodies Recently Found in Ben Franklin’s Basement http://bit.ly/1jbhjw8 In this video: Similar to why peppers taste hot, what’s going on here is there is a chemical in mint, menthol, which is tricking the brain into thinking that the area the menthol is applied to is cold; even though in fact, it’s the same as it was before. More specifically, menthol binds with cold-sensitive receptors in your skin; these receptors contain things called “ion channels”, in this case TRPM8. The menthol makes these much more sensitive than normal, so they trigger and you feel a cold sensation, even though everything is more or less the same temperature as before. Want the text version?: http://www.todayifoundout.com/index.php/2010/08/why-mint-tastes-cold/ Sources: http://en.wikipedia.org/wiki/Peppermint http://en.wikipedia.org/wiki/Mentha_spicata http://en.wikipedia.org/wiki/Mentha http://en.wikipedia.org/wiki/Menthol
-
TRPM8
published: 09 May 2011 -
WHY TOOTHPASTE FEELS COLD | TRPM8 Receptors Explained
Why does toothpaste, chewing gum and peppermint feel cold? These products are no colder than the ambient temperature around us, but they contain a chemical called L-menthol that tricks our body's TRPM8 temperature receptors. This is why mint tastes cold, and why minty products make cold things feel even colder. Some music by: X I X X: https://soundcloud.com/jeff-kaale
published: 14 Jun 2016 -
The path way of trpm8's messages
published: 08 May 2011 -
TRPM8 is a neuronal osmosensor that regulates eye blinking in mice
TRPM8 is a neuronal osmosensor that regulates eye blinking in mice. Talisia Quallo et al (2015), Nature Communications http://dx.doi.org/10.1038/ncomms8150 Specific peripheral sensory neurons respond to increases in extracellular osmolality but the mechanism responsible for excitation is unknown. Here we show that small increases in osmolality excite isolated mouse dorsal root ganglion (DRG) and trigeminal ganglion (TG) neurons expressing the cold-sensitive TRPM8 channel (transient receptor potential channel, subfamily M, member 8). Hyperosmotic responses were abolished by TRPM8 antagonists, and were absent in DRG and TG neurons isolated from Trpm8−/− mice. Heterologously expressed TRPM8 was activated by increased osmolality around physiological levels and inhibited by reduced osmolality....
published: 22 May 2015 -
TRPM8-Neuro Polar Plunge 2016
published: 30 Jan 2016 -
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8. Debapriya Ghosh et al (2016), Nature Communications http://dx.doi.org/10.1038/ncomms10489 The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although increased functional expression of TRPM8 has been implicated in various forms of pathological cold hypersensitivity, little is known about the cellular and molecular mechanisms that determine TRPM8 abundance at the plasma membrane. Here we demonstrate constitutive transport of TRPM8 towards the plasma membrane in atypical, non-acidic transport vesicles that contain lysosomal-associated membrane protein 1 (LAMP1), and provide evidence that vesicle-associated membr...
published: 04 Feb 2016 -
-
The path way of trpm8's messages.wmv
published: 08 May 2011 -
Temperature preference
Video from supplementary material for article "the menthol receptor trpm8 is the principal detector of environmental cold" (http://dx.doi.org/10.1038/nature05910).
published: 10 Jun 2007 -
Why Mint Tastes Cold
→Subscribe for new videos every day! http://bit.ly/todayifoundoutsubscribe →Why Do Superheroes Wear Their Underwear on the Outside?: http://bit.ly/1Ow7J0K Never run out of things to say at the water cooler with TodayIFoundOut! Brand new videos 7 days a week! More from TodayIFoundOut How Did Jeans Become Popular? http://bit.ly/1Q4MzaB The Numerous Bodies Recently Found in Ben Franklin’s Basement http://bit.ly/1jbhjw8 In this video: Similar to why peppers taste hot, what’s going on here is there is a chemical in mint, menthol, which is tricking the brain into thinking that the area the menthol is applied to is cold; even though in fact, it’s the same as it was before. More specifically, menthol binds with cold-sensitive receptors in your skin; these receptors contain things called “i...
published: 04 Feb 2016
TRPM8
- Order: Reorder
- Duration: 1:09
- Updated: 09 May 2011
- views: 340
- published: 09 May 2011
- views: 340
WHY TOOTHPASTE FEELS COLD | TRPM8 Receptors Explained
- Order: Reorder
- Duration: 3:12
- Updated: 14 Jun 2016
- views: 39
Why does toothpaste, chewing gum and peppermint feel cold? These products are no colder than the ambient temperature around us, but they contain a chemical call...
Why does toothpaste, chewing gum and peppermint feel cold? These products are no colder than the ambient temperature around us, but they contain a chemical called L-menthol that tricks our body's TRPM8 temperature receptors. This is why mint tastes cold, and why minty products make cold things feel even colder.
Some music by:
X I X X: https://soundcloud.com/jeff-kaale
wn.com/Why Toothpaste Feels Cold | Trpm8 Receptors Explained
Why does toothpaste, chewing gum and peppermint feel cold? These products are no colder than the ambient temperature around us, but they contain a chemical called L-menthol that tricks our body's TRPM8 temperature receptors. This is why mint tastes cold, and why minty products make cold things feel even colder.
Some music by:
X I X X: https://soundcloud.com/jeff-kaale
- published: 14 Jun 2016
- views: 39
The path way of trpm8's messages
- Order: Reorder
- Duration: 1:29
- Updated: 08 May 2011
- views: 353
- published: 08 May 2011
- views: 353
TRPM8 is a neuronal osmosensor that regulates eye blinking in mice
- Order: Reorder
- Duration: 1:12
- Updated: 22 May 2015
- views: 53
TRPM8 is a neuronal osmosensor that regulates eye blinking in mice. Talisia Quallo et al (2015), Nature Communications http://dx.doi.org/10.1038/ncomms8150
Spe...
TRPM8 is a neuronal osmosensor that regulates eye blinking in mice. Talisia Quallo et al (2015), Nature Communications http://dx.doi.org/10.1038/ncomms8150
Specific peripheral sensory neurons respond to increases in extracellular osmolality but the mechanism responsible for excitation is unknown. Here we show that small increases in osmolality excite isolated mouse dorsal root ganglion (DRG) and trigeminal ganglion (TG) neurons expressing the cold-sensitive TRPM8 channel (transient receptor potential channel, subfamily M, member 8). Hyperosmotic responses were abolished by TRPM8 antagonists, and were absent in DRG and TG neurons isolated from Trpm8−/− mice. Heterologously expressed TRPM8 was activated by increased osmolality around physiological levels and inhibited by reduced osmolality. Electrophysiological studies in a mouse corneal preparation demonstrated that osmolality regulated the electrical activity of TRPM8-expressing corneal afferent neurons. Finally, the frequency of eye blinks was reduced in Trpm8−/− compared with wild-type mice and topical administration of a TRPM8 antagonist reduced blinking in wild-type mice. Our findings identify TRPM8 as a peripheral osmosensor responsible for the regulation of normal eye-blinking in mice.
wn.com/Trpm8 Is A Neuronal Osmosensor That Regulates Eye Blinking In Mice
TRPM8 is a neuronal osmosensor that regulates eye blinking in mice. Talisia Quallo et al (2015), Nature Communications http://dx.doi.org/10.1038/ncomms8150
Specific peripheral sensory neurons respond to increases in extracellular osmolality but the mechanism responsible for excitation is unknown. Here we show that small increases in osmolality excite isolated mouse dorsal root ganglion (DRG) and trigeminal ganglion (TG) neurons expressing the cold-sensitive TRPM8 channel (transient receptor potential channel, subfamily M, member 8). Hyperosmotic responses were abolished by TRPM8 antagonists, and were absent in DRG and TG neurons isolated from Trpm8−/− mice. Heterologously expressed TRPM8 was activated by increased osmolality around physiological levels and inhibited by reduced osmolality. Electrophysiological studies in a mouse corneal preparation demonstrated that osmolality regulated the electrical activity of TRPM8-expressing corneal afferent neurons. Finally, the frequency of eye blinks was reduced in Trpm8−/− compared with wild-type mice and topical administration of a TRPM8 antagonist reduced blinking in wild-type mice. Our findings identify TRPM8 as a peripheral osmosensor responsible for the regulation of normal eye-blinking in mice.
- published: 22 May 2015
- views: 53
TRPM8-Neuro Polar Plunge 2016
- Order: Reorder
- Duration: 1:06
- Updated: 30 Jan 2016
- views: 111
- published: 30 Jan 2016
- views: 111
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8
- Order: Reorder
- Duration: 2:45
- Updated: 04 Feb 2016
- views: 27
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8. Debapriya Ghosh et al (2016), Nature Communications http://dx.doi.org/1...
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8. Debapriya Ghosh et al (2016), Nature Communications http://dx.doi.org/10.1038/ncomms10489
The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although increased functional expression of TRPM8 has been implicated in various forms of pathological cold hypersensitivity, little is known about the cellular and molecular mechanisms that determine TRPM8 abundance at the plasma membrane. Here we demonstrate constitutive transport of TRPM8 towards the plasma membrane in atypical, non-acidic transport vesicles that contain lysosomal-associated membrane protein 1 (LAMP1), and provide evidence that vesicle-associated membrane protein 7 (VAMP7) mediates fusion of these vesicles with the plasma membrane. In line herewith, VAMP7-deficient mice exhibit reduced functional expression of TRPM8 in sensory neurons and concomitant deficits in cold avoidance and icilin-induced cold hypersensitivity. Our results uncover a cellular pathway that controls functional plasma membrane incorporation of a temperature-sensitive TRP channel, and thus regulates thermosensitivity in vivo.
wn.com/Vamp7 Regulates Constitutive Membrane Incorporation Of The Cold Activated Channel Trpm8
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8. Debapriya Ghosh et al (2016), Nature Communications http://dx.doi.org/10.1038/ncomms10489
The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although increased functional expression of TRPM8 has been implicated in various forms of pathological cold hypersensitivity, little is known about the cellular and molecular mechanisms that determine TRPM8 abundance at the plasma membrane. Here we demonstrate constitutive transport of TRPM8 towards the plasma membrane in atypical, non-acidic transport vesicles that contain lysosomal-associated membrane protein 1 (LAMP1), and provide evidence that vesicle-associated membrane protein 7 (VAMP7) mediates fusion of these vesicles with the plasma membrane. In line herewith, VAMP7-deficient mice exhibit reduced functional expression of TRPM8 in sensory neurons and concomitant deficits in cold avoidance and icilin-induced cold hypersensitivity. Our results uncover a cellular pathway that controls functional plasma membrane incorporation of a temperature-sensitive TRP channel, and thus regulates thermosensitivity in vivo.
- published: 04 Feb 2016
- views: 27
Bull sperm motility upon TRPM8 modulation
- Order: Reorder
- Duration: 0:23
- Updated: 19 Jul 2015
- views: 441
The path way of trpm8's messages.wmv
- Order: Reorder
- Duration: 1:21
- Updated: 08 May 2011
- views: 26
- published: 08 May 2011
- views: 26
Temperature preference
- Order: Reorder
- Duration: 1:01
- Updated: 10 Jun 2007
- views: 1200
Video from supplementary material for article "the menthol receptor trpm8 is the principal detector of environmental cold" (http://dx.doi.org/10.1038/nature0591...
Video from supplementary material for article "the menthol receptor trpm8 is the principal detector of environmental cold" (http://dx.doi.org/10.1038/nature05910).
wn.com/Temperature Preference
Video from supplementary material for article "the menthol receptor trpm8 is the principal detector of environmental cold" (http://dx.doi.org/10.1038/nature05910).
- published: 10 Jun 2007
- views: 1200
Why Mint Tastes Cold
- Order: Reorder
- Duration: 1:21
- Updated: 04 Feb 2016
- views: 2537
→Subscribe for new videos every day! http://bit.ly/todayifoundoutsubscribe
→Why Do Superheroes Wear Their Underwear on the Outside?: http://bit.ly/1Ow7J0K
Neve...
→Subscribe for new videos every day! http://bit.ly/todayifoundoutsubscribe
→Why Do Superheroes Wear Their Underwear on the Outside?: http://bit.ly/1Ow7J0K
Never run out of things to say at the water cooler with TodayIFoundOut! Brand new videos 7 days a week!
More from TodayIFoundOut
How Did Jeans Become Popular?
http://bit.ly/1Q4MzaB
The Numerous Bodies Recently Found in Ben Franklin’s Basement
http://bit.ly/1jbhjw8
In this video:
Similar to why peppers taste hot, what’s going on here is there is a chemical in mint, menthol, which is tricking the brain into thinking that the area the menthol is applied to is cold; even though in fact, it’s the same as it was before. More specifically, menthol binds with cold-sensitive receptors in your skin; these receptors contain things called “ion channels”, in this case TRPM8. The menthol makes these much more sensitive than normal, so they trigger and you feel a cold sensation, even though everything is more or less the same temperature as before.
Want the text version?: http://www.todayifoundout.com/index.php/2010/08/why-mint-tastes-cold/
Sources:
http://en.wikipedia.org/wiki/Peppermint
http://en.wikipedia.org/wiki/Mentha_spicata
http://en.wikipedia.org/wiki/Mentha
http://en.wikipedia.org/wiki/Menthol
wn.com/Why Mint Tastes Cold
→Subscribe for new videos every day! http://bit.ly/todayifoundoutsubscribe
→Why Do Superheroes Wear Their Underwear on the Outside?: http://bit.ly/1Ow7J0K
Never run out of things to say at the water cooler with TodayIFoundOut! Brand new videos 7 days a week!
More from TodayIFoundOut
How Did Jeans Become Popular?
http://bit.ly/1Q4MzaB
The Numerous Bodies Recently Found in Ben Franklin’s Basement
http://bit.ly/1jbhjw8
In this video:
Similar to why peppers taste hot, what’s going on here is there is a chemical in mint, menthol, which is tricking the brain into thinking that the area the menthol is applied to is cold; even though in fact, it’s the same as it was before. More specifically, menthol binds with cold-sensitive receptors in your skin; these receptors contain things called “ion channels”, in this case TRPM8. The menthol makes these much more sensitive than normal, so they trigger and you feel a cold sensation, even though everything is more or less the same temperature as before.
Want the text version?: http://www.todayifoundout.com/index.php/2010/08/why-mint-tastes-cold/
Sources:
http://en.wikipedia.org/wiki/Peppermint
http://en.wikipedia.org/wiki/Mentha_spicata
http://en.wikipedia.org/wiki/Mentha
http://en.wikipedia.org/wiki/Menthol
- published: 04 Feb 2016
- views: 2537
back
- Playlist
- Chat
back
- Playlist
- Chat
1:09
TRPM8
published: 09 May 2011
TRPM8
TRPM8
- Report rights infringement
- published: 09 May 2011
- views: 340
3:12
WHY TOOTHPASTE FEELS COLD | TRPM8 Receptors Explained
Why does toothpaste, chewing gum and peppermint feel cold? These products are no colder th...
published: 14 Jun 2016
WHY TOOTHPASTE FEELS COLD | TRPM8 Receptors Explained
WHY TOOTHPASTE FEELS COLD | TRPM8 Receptors Explained
- Report rights infringement
- published: 14 Jun 2016
- views: 39
1:29
The path way of trpm8's messages
published: 08 May 2011
The path way of trpm8's messages
The path way of trpm8's messages
- Report rights infringement
- published: 08 May 2011
- views: 353
1:12
TRPM8 is a neuronal osmosensor that regulates eye blinking in mice
TRPM8 is a neuronal osmosensor that regulates eye blinking in mice. Talisia Quallo et al (...
published: 22 May 2015
TRPM8 is a neuronal osmosensor that regulates eye blinking in mice
TRPM8 is a neuronal osmosensor that regulates eye blinking in mice
- Report rights infringement
- published: 22 May 2015
- views: 53
1:06
TRPM8-Neuro Polar Plunge 2016
published: 30 Jan 2016
TRPM8-Neuro Polar Plunge 2016
TRPM8-Neuro Polar Plunge 2016
- Report rights infringement
- published: 30 Jan 2016
- views: 111
2:45
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8. D...
published: 04 Feb 2016
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8
- Report rights infringement
- published: 04 Feb 2016
- views: 27
0:23
Bull sperm motility upon TRPM8 modulation
Both activation and inhibition of TRPM8 alters sperm motility.
Majhi et al (2015), PEERJ
published: 19 Jul 2015
Bull sperm motility upon TRPM8 modulation
Bull sperm motility upon TRPM8 modulation
- Report rights infringement
- published: 19 Jul 2015
- views: 441
1:21
The path way of trpm8's messages.wmv
published: 08 May 2011
The path way of trpm8's messages.wmv
The path way of trpm8's messages.wmv
- Report rights infringement
- published: 08 May 2011
- views: 26
1:01
Temperature preference
Video from supplementary material for article "the menthol receptor trpm8 is the principal...
published: 10 Jun 2007
Temperature preference
Temperature preference
- Report rights infringement
- published: 10 Jun 2007
- views: 1200
1:21
Why Mint Tastes Cold
→Subscribe for new videos every day! http://bit.ly/todayifoundoutsubscribe
→Why Do Superhe...
published: 04 Feb 2016
Why Mint Tastes Cold
Why Mint Tastes Cold
- Report rights infringement
- published: 04 Feb 2016
- views: 2537
TRPM8...
WHY TOOTHPASTE FEELS COLD | TRPM8 Receptors Explai...
The path way of trpm8's messages...
TRPM8 is a neuronal osmosensor that regulates eye ...
TRPM8-Neuro Polar Plunge 2016...
VAMP7 regulates constitutive membrane incorporatio...
Bull sperm motility upon TRPM8 modulation...
The path way of trpm8's messages.wmv...
Temperature preference...
Why Mint Tastes Cold...
photo: AP / Evan Vucci
Reaction around the world to first Trump-Clinton debate
Edit The News Tribune 27 Sep 2016
Views from around the world on Monday's first U.S. presidential debate between Democrat Hillary Clinton and Republican Donald Trump. --- AUSTRALIA MILTON GAN, a Sydney-based photographer, said it seemed like ... ....
photo: AP / Andrew Harnik
Poll: Hillary Clinton wins first presidential debate
Edit AOL 27 Sep 2016
Republican nominee Donald Trump and Democratic nominee Hillary Clinton took the stage on Monday night for the first presidential debate, and viewers were quick to weigh in with their thoughts on which candidate was winning. According to a poll conducted on AOL.com during the debate, Clinton was the winner. Of respondents who voted during the debate, 55.4 percent said Clinton won, while 44.6 named Trump ... 21 PHOTOS ... See Gallery ... 26, 2016 ... ....
photo: AP / Keystone/Fabrice Coffrini
Italy Warns Switzerland Over Swiss-First Employment Measure
Edit WorldNews.com 26 Sep 2016
Switzerland could face consequences, Italian officials warned Monday, after voters in the border canton of Ticino approved a referendum calling on authorities to grant preference to Swiss workers over foreigners in employment, The Associated Press reported.The referendum passed with 58 percent of Ticino voters approving of the measure – an outgrowth of the Swiss nationalist efforts to limit European Union workers in Switzerland....
photo: AP / Richard Shotwell
Jennifer Aniston's necklace sends a clear message amid Brangelina divorce
Edit AOL 26 Sep 2016
Jennifer Aniston is seemingly sending a message to the world amid the still-shocking news that her ex, Brad Pitt, is getting divorced from his wife of two years, Angelina Jolie. The actress stepped out on Monday in New York's West Village in a simple black tank, boyfriend jeans and on-trend Gucci loafers. The cute, but seemingly unremarkable, outfit had a major twist that got people talking, though. Her necklace. SEE ALSO ... 6 PHOTOS ... of ... of....
photo: AP / Maya Alleruzzo
ISIS 'dead set' on using chemical weapons, US military official says
Edit Fox News 27 Sep 2016
A Pentagon spokesman said Monday that Islamic State militants are “dead set” on using chemical weapons and will likely try to use them against Iraqi forces as they prepare its siege on Mosul ... ....
« back to news headlines
Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner
Edit PNAS 12 Jun 2015
Here we report the cloning and characterization of a new functional epidermal isoform of the transient receptor potential M8 (TRPM8) mild-cold receptor, dubbed epidermal TRPM8 (eTRPM8), which is localized in the keratinocyte endoplasmic reticulum membrane and controls mitochondrial Ca2+ concentration ([Ca2+]m)....
How do we know chilli is hot and mint cool?
Edit The Guardian 27 Feb 2015
Similarly, there are free nerve endings in the skin that contain a different sensor, called TRPM8, and these can respond to both menthol and cooling. How did thermosensitive proteins such as TRPV1 and TRPM8 become sensitive to plant products like menthol and capsaicin? We can’t know for certain the sequence of evolutionary events that gave rise to these two dual-function sensors....
Menthol tricks our brain by activating cold-sensitive nerves
Edit The Daily Mail 23 Jan 2015
A researcher from Rochester University explained in The Conversation that the same effect can be observed in eucalyptus, where menthol fools the TRPM8 receptor. ....
College of Osteopathic Medicine announces recipients of 2014 Peter Morgane Research Fellowship (University of New England)
Edit noodls 03 May 2014
(Source. University of New England). Biddeford , Maine - The University of New England's College of Osteopathic Medicine (COM) Research Committee would like to congratulate the following COM students who have received the 2014 Peter Morgane Research fellowship.. 1. Robert Abdu (Class of 2017).. Project title ... research trial. Mentor ... Screening novel TRPM8 agonists to find new treatments for dry eye....
- 1
- 2
- 3
- 4
- 5
- Next page »
