Antofagasta plc (LSE: ANTO) is a Chilean business that operates in various sectors of the economy. It is one of the most important conglomerates of Chile with equity participation in Antofagasta Minerals, the railroad from Antofagasta to Bolivia, Aguas Antofagasta in Chile, Tethian in Australia and other investments in different parts from the world.

Antofagasta is listed on the London Stock Exchange and is a constituent of the FTSE 100 Index. It had a market capitalisation of approximately £12.1 billion as of 23 December 2011, making it the 33rd-largest company on the London Stock Exchange.

The Group began life as Ferrocarril de Antofagasta a Bolivia, a business that was incorporated and listed on the London Stock Exchange in 1888 with the objective of operating a railway between Antofagasta, a port on the north pacific coast of Chile, and La Paz, the capital City of Bolivia.

In 1980, a majority the shares was acquired by the Grupo Luksic and the two businesses were subsequently integrated under the name Antofagasta Holdings.