Brandon Keith James (born December 21, 1987) is an American professional football wide receiver and kick returner who is currently a free agent, and last played for the Edmonton Eskimos of the Canadian Football League (CFL). James played college football for the University of Florida, and received All-American honors. Thereafter, he has played professionally for the Indianapolis Colts of the National Football League (NFL) and the Edmonton Eskimos.

James was born in St. Augustine, Florida in 1987. He attended St. Augustine High School, where he was a standout running back for the St. Augustine Yellow Jackets high school football team. As a senior team captain in 2005, James ran for 900 yards and eight touchdowns while leading the Yellow Jackets to a Florida Class 3A state championship.

James received an athletic scholarship to attend the University of Florida in Gainesville, Florida, where he played for coach Urban Meyer's Florida Gators football team from 2006 to 2009. As a freshman in 2006, James saw immediate playing time as a kick return specialist, returning thirty-three punts for 363 yards and one touchdown in 2006, and earning Freshman All-Southeastern Conference (SEC) and Freshman All-American honors. His 33-yard kickoff return against the Ohio State Buckeyes in the 2007 BCS National Championship Game gave the Gators the ball in Buckeye territory after Ohio State's Ted Ginn, Jr. opened the game with a kickoff return for a touchdown. James' dramatic return and the Gators' resulting touchdown changed the early momentum of the game, with the Gators ultimately defeating the top-ranked Buckeyes 41–14 to win the BCS National Championship.