- published: 25 Dec 2020
- views: 81339
-
remove the playlistSympathomimetic Drug
- remove the playlistSympathomimetic Drug
Sympathomimetic drug
Sympathomimetic drugs are stimulant compounds which mimic the effects of agonists of the sympathetic nervous system such as the catecholamines. (epinephrine (adrenaline), norepinephrine (noradrenaline), dopamine, etc.) Sympathomimetic drugs are used to treat cardiac arrest and low blood pressure, or even delay premature labor, among other things.
These drugs can act through several mechanisms, such as directly activating postsynaptic receptors, blocking breakdown and reuptake of certain neurotransmitters, or stimulating production and release of catecholamines.
Mechanisms of action
The mechanisms of sympathomimetic drugs can be direct-acting, such as α-adrenergic agonists, β-adrenergic agonists, and dopaminergic agonists; or indirect-acting, such as MAOIs, COMT inhibitors, release stimulants, and reuptake inhibitors that increase the levels of endogenous catecholamines.
Structure-activity relationship
For maximum sympathomimetic activity, a drug must have:
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Sympathomimetic_drug
Adrenergic
Adrenergic means "working on adrenaline (epinephrine) or noradrenaline (norepinephrine)".
Regarding proteins:
Regarding drugs:
See also
References
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Adrenergic
Podcasts:
-
1.Sympathomimetic drugs Introduction - ANS Pharmacology
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash 📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr 📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash 1.Sympathomimetic drugs Introduction - ANS Pharmacology Sympathomimetics are substances that mimic or modify the actions of endogenous catecholamines of the sympathetic nervous system. Direct agonists directly activate adrenergic receptors while indirect agonists enhance the actions of endogenous catecholamines. Sympathomimetics stimulates alpha-1 adrenergic receptors, beta-adrenergic receptors, and dopamine (D) receptors in various target tissues, such as the eyes, heart, and vascular smooth muscle. The clinical indications for sympathomimetics are broad and include asthma, heart failure, shock, ...
published: 25 Dec 2020 -
Sympathomimetics (Adrenergic Agonists)—Epinephrine, Norepinephrine - Alpha & Beta Receptors
Sympathomimetics (Adrenergic Agonists)—Catecholamines (Epinephrine, Norepinephrine, Dopamine), Alpha & Beta Receptors…Alpha adrenergic receptors (alpha 1, alpha 2), beta adrenergic (beta 1, beta 2, beta 3). receptors. Sympathetic autonomic nervous system (SANS). Alpha agonists, alpha antagonists (alpha blockers), beta agonists, beta antagonists (beta blockers). Autonomic pharmacology, Asthma treatment, Respiratory pharmacology, cardiovascular pharmacology, Hypertension pharmacology. 💊🦠 Antibiotics Course: https://www.medicosisperfectionalis.com/products/courses/antibiotics/ 💦 🐳 Kidney Physiology Course: https://www.medicosisperfectionalis.com/products/ 🤰 ObGyn Highyields Course: https://www.medicosisperfectionalis.com/ 🚨 Emergency Medicine HighYields Course: https://www.medicosisperfectio...
published: 25 Nov 2023 -
Autonomic Pharmacology | Adrenergic Agonists
Official Ninja Nerd Website: https://ninjanerd.org You can find the NOTES and ILLUSTRATIONS for this lecture on our website at: https://www.ninjanerd.org/lecture/autonomic-pharmacology-adrenergic-agonists Ninja Nerds! In this lecture Professor Zach Murphy will be presenting on Adrenergic Agonists within our short series on Autonomic Pharmacology. We hope you enjoy this lecture and be sure to support us below! Table of Contents: 0:00 Lab 0:07 Adrenergic Agonists Introduction 1:06 Adrenergic Neurons and Receptors 19:32 Adrenergic Target Organ Effects 30:34 Alpha 1 Agonists 39:38 Alpha 2 Agonists 47:48 Beta 1 Agonists 51:42 Beta 1 + 2 Agonists 56:19 Beta 2 Agonists 1:02:47 Beta 3 Agonists 1:04:07 Alpha + Beta Agonists 1:13:17 Epinephrine + Dopamine 1:22:30 Norepinephrine Graphical Represen...
published: 23 Sep 2022 -
Sympathomimetics Mechanism and Side Effects
Sympathomimetics, also known as adrenergic agonists or adrenergic agonist drugs, are a class of medications that mimic the effects of the sympathetic nervous system's neurotransmitters, particularly norepinephrine and epinephrine (adrenaline). The sympathetic nervous system is responsible for the "fight or flight" response in the body, which prepares the body for stressful situations by increasing heart rate, dilating airways, redirecting blood flow to the muscles, and more. Sympathomimetic drugs can either directly activate adrenergic receptors or increase the release of norepinephrine and epinephrine. These drugs have a wide range of therapeutic applications due to their ability to stimulate various physiological responses. Some common uses of sympathomimetics include: 1. Cardiovascula...
published: 28 May 2021 -
Pharmacology - ADRENERGIC RECEPTORS & AGONISTS (MADE EASY)
👉📖 READY TO ACE YOUR EXAM? 📚 GET STUDY NOTES ON PATREON! https://www.patreon.com/speedpharmacology Adrenergic agonists are a group of drugs that stimulate alpha and beta adrenergic receptors by mimicking the action of naturally occurring catecholamines such as norepinephrine, epinephrine and dopamine. This pharmacology lecture covers topics such as mechanism of action of adrenergic agonists; catecholamines, noncatecholamines, direct acting, indirect acting, mixed action; location and function of alpha and beta receptors. Adrenergic agonists mentioned include: Epinephrine, Norepinephrine, Dopamine, Oxymetazoline, Phenylephrine, Clonidine, Dobutamine, Albuterol, Terbutaline, Salmeterol, Formoterol, Mirabegron, Cocaine, Amphetamine, Ephedrine, Pseudoephedrine. Thanks for watching and don't ...
published: 21 Sep 2016 -
Adrenergic Drugs - Pharmacology, Animation
(USMLE topics) Adrenergic receptors and drugs, agonists and antagonists, mechanisms of action. Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images. Voice by: Ashley Fleming ©Alila Medical Media. All rights reserved. All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition. Adrenergic drugs are medications that stimulate (sympathomimetic) or inhibit (sympatholytic) adrenergic receptors. Adrenergic...
published: 22 Jun 2020 -
Classification of Adrenergic Drugs || Individual Adrenergic Drugs || Sympathomimetics Pharmacology
📝 Find notes here: https://www.nonstopneuron.com/post/classification-of-adrenergic-drugs 🌐 Explore our entire animation video library: https://www.nonstopneuron.com/ ● Follow me at: • Instagram: https://www.instagram.com/NonstopNeuron/ • Facebook: https://www.facebook.com/NonstopNeuron Classification of Adrenergic Drugs Classification of adrenergic drugs includes endogenous catecholamines, drugs that act directly on the receptors, indirectly acting drugs, and mixed-acting sympathomimetics. Endogenous catecholamines are epinephrine, norepinephrine, and dopamine. Selective α1 agonists are phenylephrine, methoxamine, and midodrine. Selective α2 agonists are clonidine, methyldopa, guanfacine, guanabenz, moxonidine, rilmenidine, dexmedetomidine, tizanidine, naphazoline, xylometazoline, oxymet...
published: 20 Sep 2022 -
2.Sympathomimetic Drugs - Directly Acting sympathomimetic Drugs (Part 1)
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash 📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr 📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash 2.Sympathomimetic Drugs - Directly Acting sympathomimetic Drugs (Part 1) Sympathomimetics are substances that mimic or modify the actions of endogenous catecholamines of the sympathetic nervous system. Direct agonists directly activate adrenergic receptors while indirect agonists enhance the actions of endogenous catecholamines. Sympathomimetics stimulates alpha-1 adrenergic receptors, beta-adrenergic receptors, and dopamine (D) receptors in various target tissues, such as the eyes, heart, and vascular smooth muscle. The clinical indications for sympathomimetics are broad and include asthma, hear...
published: 25 Dec 2020 -
Adrenergic Drugs Part 1 | Pharmacology | Dr Najeeb👨⚕️
#drnajeeb #pharmacology #medicines #adrenergic #drugs # adrenergicdrugs Adrenergic Drugs Part 1 | Pharmacology | Dr Najeeb👨⚕️ Like this video? Sign up now on our website at https://www.DrNajeebLectures.com to access 1000+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $59 ONLY! Sign up now on our website at https://members.drnajeeblectures.com/#!/register-fast --------------------------------------------------------------------------------------------------------------------------- Why sign up for premium membership? Here's why! Membership Features for premium website members. 1. More than 1000+ Medi...
published: 26 Mar 2023 -
Sympathomimetics or Adrenergic Receptor Agonists pharmacology MADE EASY!
Sympathomimetics/ Adrenergic agonists are substances that mimic or modify the actions of endogenous catecholamines of the sympathetic nervous system. Direct agonists directly activate adrenergic receptors while indirect agonists enhance the actions of endogenous catecholamines.
published: 26 Aug 2019
8:00
1.Sympathomimetic drugs Introduction - ANS Pharmacology
- Order: Reorder
- Duration: 8:00
- Uploaded Date: 25 Dec 2020
- views: 81339
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- ...
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash
1.Sympathomimetic drugs Introduction - ANS Pharmacology
Sympathomimetics are substances that mimic or modify the actions of endogenous catecholamines of the sympathetic nervous system. Direct agonists directly activate adrenergic receptors while indirect agonists enhance the actions of endogenous catecholamines. Sympathomimetics stimulates alpha-1 adrenergic receptors, beta-adrenergic receptors, and dopamine (D) receptors in various target tissues, such as the eyes, heart, and vascular smooth muscle. The clinical indications for sympathomimetics are broad and include asthma, heart failure, shock, and anaphylaxis. Side effects include hypertension, sinus tachycardia, and skeletal muscle tremor.
#sympathomimetics #sympathomimetic #sympathomimeticdrugs #sympathomimeticagents #sympathomimeticspharmacology #mbbspharmacology #anspharmacology #adrenergicpharmacology ##pharmacologyofans #autonomicpharmacology #autonomicnervoussystem #pharmacology
https://wn.com/1.Sympathomimetic_Drugs_Introduction_Ans_Pharmacology
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash
1.Sympathomimetic drugs Introduction - ANS Pharmacology
Sympathomimetics are substances that mimic or modify the actions of endogenous catecholamines of the sympathetic nervous system. Direct agonists directly activate adrenergic receptors while indirect agonists enhance the actions of endogenous catecholamines. Sympathomimetics stimulates alpha-1 adrenergic receptors, beta-adrenergic receptors, and dopamine (D) receptors in various target tissues, such as the eyes, heart, and vascular smooth muscle. The clinical indications for sympathomimetics are broad and include asthma, heart failure, shock, and anaphylaxis. Side effects include hypertension, sinus tachycardia, and skeletal muscle tremor.
#sympathomimetics #sympathomimetic #sympathomimeticdrugs #sympathomimeticagents #sympathomimeticspharmacology #mbbspharmacology #anspharmacology #adrenergicpharmacology ##pharmacologyofans #autonomicpharmacology #autonomicnervoussystem #pharmacology
1:05:39
Sympathomimetics (Adrenergic Agonists)—Epinephrine, Norepinephrine - Alpha & Beta Receptors
- Order: Reorder
- Duration: 1:05:39
- Uploaded Date: 25 Nov 2023
- views: 24221
Sympathomimetics (Adrenergic Agonists)—Catecholamines (Epinephrine, Norepinephrine, Dopamine), Alpha & Beta Receptors…Alpha adrenergic receptors (alpha 1, alpha...
Sympathomimetics (Adrenergic Agonists)—Catecholamines (Epinephrine, Norepinephrine, Dopamine), Alpha & Beta Receptors…Alpha adrenergic receptors (alpha 1, alpha 2), beta adrenergic (beta 1, beta 2, beta 3). receptors. Sympathetic autonomic nervous system (SANS). Alpha agonists, alpha antagonists (alpha blockers), beta agonists, beta antagonists (beta blockers). Autonomic pharmacology, Asthma treatment, Respiratory pharmacology, cardiovascular pharmacology, Hypertension pharmacology.
💊🦠 Antibiotics Course: https://www.medicosisperfectionalis.com/products/courses/antibiotics/
💦 🐳 Kidney Physiology Course: https://www.medicosisperfectionalis.com/products/
🤰 ObGyn Highyields Course: https://www.medicosisperfectionalis.com/
🚨 Emergency Medicine HighYields Course: https://www.medicosisperfectionalis.com/
😷 Surgery HighYields Course: https://www.medicosisperfectionalis.com/
💊 📛 Toxicology Course: https://www.medicosisperfectionalis.com/
❤️ Cardiac Pharmacology Course: https://www.medicosisperfectionalis.com/
🧪Acid-Base Course: https://www.medicosisperfectionalis.com/products/
🧠 Autonomic Pharmacology Course: www.medicosisperfectionalis.com/
🧪 Electrolytes Course: https://www.medicosisperfectionalis.com/
🍱 Endocrine Pharmacology Course: https://www.medicosisperfectionalis.com/products/
🧠 CNS Pharmacology Course: https://www.medicosisperfectionalis.com/
💊 General Pharmacology (Pharmacokinetics and Pharmacodynamics): https://www.medicosisperfectionalis.com/
📝 Download my handwritten notes: www.medicosisperfectionalis.com/
⁉️ Questions and Answers: https://www.medicosisperfectionalis.com/
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG
🎁Free Stuff: https://www.medicosisperfectionalis.com/
💊 Pharmacology Lectures: https://www.medicosisperfectionalis.com/
YouTube PLAYLISTS:
► 🧠 Physiology Playlist: https://www.youtube.com/watch?v=6qk_LTVXZ2w&list;=PLYcLrRDaR8_eAjmngd289ghWijs2wfqnj&index;=2&t;=0s
🧫 🦠 Microbiology and Infectious Diseases Playlist: https://youtube.com/playlist?list=PLYcLrRDaR8_ftu9ms-ytDewlhJxYNuIYo
► 🩸 Hematology videos: https://www.youtube.com/playlist?list=PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU
► 💪 Rheumatology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_ckdsow-7buX1rIzIEKfxZQ
► ❤️ Cardiac Pharmacology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_e3pM6ifeZDfNPlE3K4KF3J
► Biochemistry 🧪 : https://youtube.com/playlist?list=PLYcLrRDaR8_c2LBpF_OYvwijOok7ae96N
►🔥Chemistry: https://youtube.com/playlist?list=PLYcLrRDaR8_e4MrgwcOjbt3mS4nUbSs8w
► 🙌 Support me on cash app: https://cash.app/$medicosis/
► Support me on Stripe: https://donate.stripe.com/3cs02Hb9ca2k4c8fYZ
► 😍 Support me on Patreon: https://www.patreon.com/medicosis/
► Support me on Venmo: Venmo: https://venmo.com/medicosis
► 🥰 Support me on PayPal: https://www.paypal.me/perfectionalis/
► ☕️ Buy me a Coffee: https://www.buymeacoffee.com/medicosis/
► 😚 Join my Channel on YouTube: https://www.youtube.com/channel/UCl-J-ovSJhA3or73Q2uVpow/join
--If you’ve joined my channel on youtube (the join button that's next to the subscribe button), then go to the "membership tab" and you will find some member-only posts/videos.
► 👨🏫 All of my premium courses are ON SALE: https://www.medicosisperfectionalis.com/
📚 Recommended Books: https://www.amazon.com/shop/medicosisperfectionalis/
► ❓If you have any questions, please email me at: medicosisperfectionalis@gmail.com
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG/
►Website: https://www.medicosisperfectionalis.com/
►Patreon: https://www.patreon.com/medicosis/
►YouTube: https://www.youtube.com/c/MedicosisPerfectionalis or:
► Like my page on Facebook https://www.facebook.com/medicosis/
►Follow us on Instagram here: https://www.instagram.com/medicosisperfectionalis/
►PayPal: https://www.paypal.me/perfectionalis/
►Venmo: @medicosis
►Facebook: https://www.facebook.com/medicosis/
►Twitter: https://www.twitter.com/medicosis/
►SoundCloud: https://soundcloud.com/medicosis/
►TikTok: www.tiktok.com/@medicosisp/
►LinkedIn: linkedin.com/in/medicosis-perfectionalis-873886197/
►Snapchat: https://www.snapchat.com/add/medicosis/
►Pinterest: https://www.pinterest.com/medicosisperfectionalis/
►Rumble: https://rumble.com/user/MedicosisPerfectionalis/
► Tumblr: https://medicosis.tumblr.com/
Thank you so much for supporting my channel! Love ❤️& Happy studying!!
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
📱Save on your mobile phone bill: http://fbuy.me/q6bMj
📊 My favorite Productivity App: https://airtable.com/invite/r/2zH40fus/
🙋♀️ Qbank (TrueLearn): https://truelearn.referralrock.com/l/MEDICOSIS/
🙌 Support the channel: https://donate.stripe.com/3cs02Hb9ca2k4c8fYZ
https://wn.com/Sympathomimetics_(Adrenergic_Agonists)—Epinephrine,_Norepinephrine_Alpha_Beta_Receptors
Sympathomimetics (Adrenergic Agonists)—Catecholamines (Epinephrine, Norepinephrine, Dopamine), Alpha & Beta Receptors…Alpha adrenergic receptors (alpha 1, alpha 2), beta adrenergic (beta 1, beta 2, beta 3). receptors. Sympathetic autonomic nervous system (SANS). Alpha agonists, alpha antagonists (alpha blockers), beta agonists, beta antagonists (beta blockers). Autonomic pharmacology, Asthma treatment, Respiratory pharmacology, cardiovascular pharmacology, Hypertension pharmacology.
💊🦠 Antibiotics Course: https://www.medicosisperfectionalis.com/products/courses/antibiotics/
💦 🐳 Kidney Physiology Course: https://www.medicosisperfectionalis.com/products/
🤰 ObGyn Highyields Course: https://www.medicosisperfectionalis.com/
🚨 Emergency Medicine HighYields Course: https://www.medicosisperfectionalis.com/
😷 Surgery HighYields Course: https://www.medicosisperfectionalis.com/
💊 📛 Toxicology Course: https://www.medicosisperfectionalis.com/
❤️ Cardiac Pharmacology Course: https://www.medicosisperfectionalis.com/
🧪Acid-Base Course: https://www.medicosisperfectionalis.com/products/
🧠 Autonomic Pharmacology Course: www.medicosisperfectionalis.com/
🧪 Electrolytes Course: https://www.medicosisperfectionalis.com/
🍱 Endocrine Pharmacology Course: https://www.medicosisperfectionalis.com/products/
🧠 CNS Pharmacology Course: https://www.medicosisperfectionalis.com/
💊 General Pharmacology (Pharmacokinetics and Pharmacodynamics): https://www.medicosisperfectionalis.com/
📝 Download my handwritten notes: www.medicosisperfectionalis.com/
⁉️ Questions and Answers: https://www.medicosisperfectionalis.com/
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG
🎁Free Stuff: https://www.medicosisperfectionalis.com/
💊 Pharmacology Lectures: https://www.medicosisperfectionalis.com/
YouTube PLAYLISTS:
► 🧠 Physiology Playlist: https://www.youtube.com/watch?v=6qk_LTVXZ2w&list;=PLYcLrRDaR8_eAjmngd289ghWijs2wfqnj&index;=2&t;=0s
🧫 🦠 Microbiology and Infectious Diseases Playlist: https://youtube.com/playlist?list=PLYcLrRDaR8_ftu9ms-ytDewlhJxYNuIYo
► 🩸 Hematology videos: https://www.youtube.com/playlist?list=PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU
► 💪 Rheumatology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_ckdsow-7buX1rIzIEKfxZQ
► ❤️ Cardiac Pharmacology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_e3pM6ifeZDfNPlE3K4KF3J
► Biochemistry 🧪 : https://youtube.com/playlist?list=PLYcLrRDaR8_c2LBpF_OYvwijOok7ae96N
►🔥Chemistry: https://youtube.com/playlist?list=PLYcLrRDaR8_e4MrgwcOjbt3mS4nUbSs8w
► 🙌 Support me on cash app: https://cash.app/$medicosis/
► Support me on Stripe: https://donate.stripe.com/3cs02Hb9ca2k4c8fYZ
► 😍 Support me on Patreon: https://www.patreon.com/medicosis/
► Support me on Venmo: Venmo: https://venmo.com/medicosis
► 🥰 Support me on PayPal: https://www.paypal.me/perfectionalis/
► ☕️ Buy me a Coffee: https://www.buymeacoffee.com/medicosis/
► 😚 Join my Channel on YouTube: https://www.youtube.com/channel/UCl-J-ovSJhA3or73Q2uVpow/join
--If you’ve joined my channel on youtube (the join button that's next to the subscribe button), then go to the "membership tab" and you will find some member-only posts/videos.
► 👨🏫 All of my premium courses are ON SALE: https://www.medicosisperfectionalis.com/
📚 Recommended Books: https://www.amazon.com/shop/medicosisperfectionalis/
► ❓If you have any questions, please email me at: medicosisperfectionalis@gmail.com
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG/
►Website: https://www.medicosisperfectionalis.com/
►Patreon: https://www.patreon.com/medicosis/
►YouTube: https://www.youtube.com/c/MedicosisPerfectionalis or:
► Like my page on Facebook https://www.facebook.com/medicosis/
►Follow us on Instagram here: https://www.instagram.com/medicosisperfectionalis/
►PayPal: https://www.paypal.me/perfectionalis/
►Venmo: @medicosis
►Facebook: https://www.facebook.com/medicosis/
►Twitter: https://www.twitter.com/medicosis/
►SoundCloud: https://soundcloud.com/medicosis/
►TikTok: www.tiktok.com/@medicosisp/
►LinkedIn: linkedin.com/in/medicosis-perfectionalis-873886197/
►Snapchat: https://www.snapchat.com/add/medicosis/
►Pinterest: https://www.pinterest.com/medicosisperfectionalis/
►Rumble: https://rumble.com/user/MedicosisPerfectionalis/
► Tumblr: https://medicosis.tumblr.com/
Thank you so much for supporting my channel! Love ❤️& Happy studying!!
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
📱Save on your mobile phone bill: http://fbuy.me/q6bMj
📊 My favorite Productivity App: https://airtable.com/invite/r/2zH40fus/
🙋♀️ Qbank (TrueLearn): https://truelearn.referralrock.com/l/MEDICOSIS/
🙌 Support the channel: https://donate.stripe.com/3cs02Hb9ca2k4c8fYZ
- published: 25 Nov 2023
- views: 24221
1:45:41
Autonomic Pharmacology | Adrenergic Agonists
- Order: Reorder
- Duration: 1:45:41
- Uploaded Date: 23 Sep 2022
- views: 257514
Official Ninja Nerd Website: https://ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
https://www.ninjanerd.org/lectu...
Official Ninja Nerd Website: https://ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
https://www.ninjanerd.org/lecture/autonomic-pharmacology-adrenergic-agonists
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Adrenergic Agonists within our short series on Autonomic Pharmacology. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Adrenergic Agonists Introduction
1:06 Adrenergic Neurons and Receptors
19:32 Adrenergic Target Organ Effects
30:34 Alpha 1 Agonists
39:38 Alpha 2 Agonists
47:48 Beta 1 Agonists
51:42 Beta 1 + 2 Agonists
56:19 Beta 2 Agonists
1:02:47 Beta 3 Agonists
1:04:07 Alpha + Beta Agonists
1:13:17 Epinephrine + Dopamine
1:22:30 Norepinephrine Graphical Representation
1:29:48 Epinephrine Graphical Representation
1:34:49 Isoproterenol Graphical Representation
1:39:11 Adrenergic Agonists Practice Problems
1:45:20 Comment, Like, SUBSCRIBE!
Supplemental Lecture: Neurology | Adrenergic Receptors -- https://youtu.be/ZLW8V7bwW4U
Pharmacology Source:
Whalen, Karen. Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). Wolters Kluwer Health. Kindle Edition.
Join this channel to get access to perks:
https://www.youtube.com/channel/UC6QYFutt9cluQ3uSM963_KQ/join
APPAREL |
https://shop.ninjanerd.org
https://www.amazon.com/s?k=ninja+nerd&ref;=nb_sb_noss_2
PODCAST |
Apple Podcast: https://podcasts.apple.com/us/podcast/ninja-nerd/id1611469997
Spotify: https://open.spotify.com/show/2ZDXoakATwCgkRH3EpCZYu?si=922326f893f4437e
Google Podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5idXp6c3Byb3V0LmNvbS8xOTQ1NjU1LnJzcw==
DONATE
PAYPAL | https://www.paypal.com/paypalme/ninjanerdscience
SOCIAL MEDIA
FACEBOOK | https://www.facebook.com/NinjaNerdlectures
INSTAGRAM | https://www.instagram.com/ninjanerdlectures
TWITTER | https://twitter.com/ninjanerdsci
@NinjaNerdSci
DISCORD | https://discord.gg/3srTG4dngW
#ninjanerd #pharmacology #AdrenergicAgonists
https://wn.com/Autonomic_Pharmacology_|_Adrenergic_Agonists
Official Ninja Nerd Website: https://ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
https://www.ninjanerd.org/lecture/autonomic-pharmacology-adrenergic-agonists
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Adrenergic Agonists within our short series on Autonomic Pharmacology. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Adrenergic Agonists Introduction
1:06 Adrenergic Neurons and Receptors
19:32 Adrenergic Target Organ Effects
30:34 Alpha 1 Agonists
39:38 Alpha 2 Agonists
47:48 Beta 1 Agonists
51:42 Beta 1 + 2 Agonists
56:19 Beta 2 Agonists
1:02:47 Beta 3 Agonists
1:04:07 Alpha + Beta Agonists
1:13:17 Epinephrine + Dopamine
1:22:30 Norepinephrine Graphical Representation
1:29:48 Epinephrine Graphical Representation
1:34:49 Isoproterenol Graphical Representation
1:39:11 Adrenergic Agonists Practice Problems
1:45:20 Comment, Like, SUBSCRIBE!
Supplemental Lecture: Neurology | Adrenergic Receptors -- https://youtu.be/ZLW8V7bwW4U
Pharmacology Source:
Whalen, Karen. Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). Wolters Kluwer Health. Kindle Edition.
Join this channel to get access to perks:
https://www.youtube.com/channel/UC6QYFutt9cluQ3uSM963_KQ/join
APPAREL |
https://shop.ninjanerd.org
https://www.amazon.com/s?k=ninja+nerd&ref;=nb_sb_noss_2
PODCAST |
Apple Podcast: https://podcasts.apple.com/us/podcast/ninja-nerd/id1611469997
Spotify: https://open.spotify.com/show/2ZDXoakATwCgkRH3EpCZYu?si=922326f893f4437e
Google Podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5idXp6c3Byb3V0LmNvbS8xOTQ1NjU1LnJzcw==
DONATE
PAYPAL | https://www.paypal.com/paypalme/ninjanerdscience
SOCIAL MEDIA
FACEBOOK | https://www.facebook.com/NinjaNerdlectures
INSTAGRAM | https://www.instagram.com/ninjanerdlectures
TWITTER | https://twitter.com/ninjanerdsci
@NinjaNerdSci
DISCORD | https://discord.gg/3srTG4dngW
#ninjanerd #pharmacology #AdrenergicAgonists
- published: 23 Sep 2022
- views: 257514
4:59
Sympathomimetics Mechanism and Side Effects
- Order: Reorder
- Duration: 4:59
- Uploaded Date: 28 May 2021
- views: 5631
Sympathomimetics, also known as adrenergic agonists or adrenergic agonist drugs, are a class of medications that mimic the effects of the sympathetic nervous sy...
Sympathomimetics, also known as adrenergic agonists or adrenergic agonist drugs, are a class of medications that mimic the effects of the sympathetic nervous system's neurotransmitters, particularly norepinephrine and epinephrine (adrenaline). The sympathetic nervous system is responsible for the "fight or flight" response in the body, which prepares the body for stressful situations by increasing heart rate, dilating airways, redirecting blood flow to the muscles, and more. Sympathomimetic drugs can either directly activate adrenergic receptors or increase the release of norepinephrine and epinephrine.
These drugs have a wide range of therapeutic applications due to their ability to stimulate various physiological responses. Some common uses of sympathomimetics include:
1. Cardiovascular Conditions: Sympathomimetics can be used to treat conditions like low blood pressure (hypotension) and cardiac arrest by increasing heart rate and improving blood flow.
2. Asthma and Bronchospasm: Sympathomimetic drugs like albuterol are used to dilate bronchial passages in conditions such as asthma and chronic obstructive pulmonary disease (COPD), helping to relieve breathing difficulties.
3. Nasal Congestion: Decongestant medications containing sympathomimetics, like pseudoephedrine, can help alleviate nasal congestion by narrowing blood vessels in the nasal passages.
4. Allergic Reactions: Epinephrine (adrenaline) is used as an emergency treatment for severe allergic reactions (anaphylaxis). It can quickly reverse the symptoms of anaphylaxis, including airway constriction, low blood pressure, and hives.
5. Attention Deficit Hyperactivity Disorder (ADHD): Some sympathomimetics, like methylphenidate and amphetamine-based drugs, are used to manage symptoms of ADHD by increasing focus and reducing hyperactivity.
6. Weight Loss: Certain sympathomimetics can act as appetite suppressants and stimulate metabolism, making them potential components of weight loss medications.
7. Local Anesthesia: Epinephrine is sometimes added to local anesthetic solutions to prolong the effects of the anesthetic and reduce bleeding at the site.
8. Shock and Hypotension: In emergency medicine, sympathomimetics can be used to raise blood pressure in cases of shock or severe hypotension.
It's important to note that sympathomimetic drugs can have various side effects and contraindications. Common side effects can include increased heart rate, elevated blood pressure, anxiety, restlessness, insomnia, and tremors. Some individuals may be more sensitive to these effects than others. Also, prolonged or excessive use of sympathomimetics can lead to tolerance, dependence, and potential abuse.
Due to their potential to impact cardiovascular function and other physiological processes, sympathomimetics should be used under the guidance and prescription of a healthcare professional. The specific drug chosen, dosage, and duration of treatment will depend on the medical condition being treated and the patient's individual health profile.
https://wn.com/Sympathomimetics_Mechanism_And_Side_Effects
Sympathomimetics, also known as adrenergic agonists or adrenergic agonist drugs, are a class of medications that mimic the effects of the sympathetic nervous system's neurotransmitters, particularly norepinephrine and epinephrine (adrenaline). The sympathetic nervous system is responsible for the "fight or flight" response in the body, which prepares the body for stressful situations by increasing heart rate, dilating airways, redirecting blood flow to the muscles, and more. Sympathomimetic drugs can either directly activate adrenergic receptors or increase the release of norepinephrine and epinephrine.
These drugs have a wide range of therapeutic applications due to their ability to stimulate various physiological responses. Some common uses of sympathomimetics include:
1. Cardiovascular Conditions: Sympathomimetics can be used to treat conditions like low blood pressure (hypotension) and cardiac arrest by increasing heart rate and improving blood flow.
2. Asthma and Bronchospasm: Sympathomimetic drugs like albuterol are used to dilate bronchial passages in conditions such as asthma and chronic obstructive pulmonary disease (COPD), helping to relieve breathing difficulties.
3. Nasal Congestion: Decongestant medications containing sympathomimetics, like pseudoephedrine, can help alleviate nasal congestion by narrowing blood vessels in the nasal passages.
4. Allergic Reactions: Epinephrine (adrenaline) is used as an emergency treatment for severe allergic reactions (anaphylaxis). It can quickly reverse the symptoms of anaphylaxis, including airway constriction, low blood pressure, and hives.
5. Attention Deficit Hyperactivity Disorder (ADHD): Some sympathomimetics, like methylphenidate and amphetamine-based drugs, are used to manage symptoms of ADHD by increasing focus and reducing hyperactivity.
6. Weight Loss: Certain sympathomimetics can act as appetite suppressants and stimulate metabolism, making them potential components of weight loss medications.
7. Local Anesthesia: Epinephrine is sometimes added to local anesthetic solutions to prolong the effects of the anesthetic and reduce bleeding at the site.
8. Shock and Hypotension: In emergency medicine, sympathomimetics can be used to raise blood pressure in cases of shock or severe hypotension.
It's important to note that sympathomimetic drugs can have various side effects and contraindications. Common side effects can include increased heart rate, elevated blood pressure, anxiety, restlessness, insomnia, and tremors. Some individuals may be more sensitive to these effects than others. Also, prolonged or excessive use of sympathomimetics can lead to tolerance, dependence, and potential abuse.
Due to their potential to impact cardiovascular function and other physiological processes, sympathomimetics should be used under the guidance and prescription of a healthcare professional. The specific drug chosen, dosage, and duration of treatment will depend on the medical condition being treated and the patient's individual health profile.
- published: 28 May 2021
- views: 5631
17:51
Pharmacology - ADRENERGIC RECEPTORS & AGONISTS (MADE EASY)
- Order: Reorder
- Duration: 17:51
- Uploaded Date: 21 Sep 2016
- views: 2160755
👉📖 READY TO ACE YOUR EXAM? 📚 GET STUDY NOTES ON PATREON!
https://www.patreon.com/speedpharmacology
Adrenergic agonists are a group of drugs that stimulate alph...
👉📖 READY TO ACE YOUR EXAM? 📚 GET STUDY NOTES ON PATREON!
https://www.patreon.com/speedpharmacology
Adrenergic agonists are a group of drugs that stimulate alpha and beta adrenergic receptors by mimicking the action of naturally occurring catecholamines such as norepinephrine, epinephrine and dopamine. This pharmacology lecture covers topics such as mechanism of action of adrenergic agonists; catecholamines, noncatecholamines, direct acting, indirect acting, mixed action; location and function of alpha and beta receptors. Adrenergic agonists mentioned include: Epinephrine, Norepinephrine, Dopamine, Oxymetazoline, Phenylephrine, Clonidine, Dobutamine, Albuterol, Terbutaline, Salmeterol, Formoterol, Mirabegron, Cocaine, Amphetamine, Ephedrine, Pseudoephedrine.
Thanks for watching and don't forget to SUBSCRIBE, hit the LIKE button👍 and click the BELL button🔔 for future notifications!!!
0:00 Intro
0:44 Adrenergic neuron
3:01 Adrenergic receptors
3:45 Alpha receptors
6:21 Beta receptors
8:22 Adrenergic agonists
10:20 Direct-acting agonists
15:53 Indirect-acting agonists
16:37 Mixed-action agonists
https://wn.com/Pharmacology_Adrenergic_Receptors_Agonists_(Made_Easy)
👉📖 READY TO ACE YOUR EXAM? 📚 GET STUDY NOTES ON PATREON!
https://www.patreon.com/speedpharmacology
Adrenergic agonists are a group of drugs that stimulate alpha and beta adrenergic receptors by mimicking the action of naturally occurring catecholamines such as norepinephrine, epinephrine and dopamine. This pharmacology lecture covers topics such as mechanism of action of adrenergic agonists; catecholamines, noncatecholamines, direct acting, indirect acting, mixed action; location and function of alpha and beta receptors. Adrenergic agonists mentioned include: Epinephrine, Norepinephrine, Dopamine, Oxymetazoline, Phenylephrine, Clonidine, Dobutamine, Albuterol, Terbutaline, Salmeterol, Formoterol, Mirabegron, Cocaine, Amphetamine, Ephedrine, Pseudoephedrine.
Thanks for watching and don't forget to SUBSCRIBE, hit the LIKE button👍 and click the BELL button🔔 for future notifications!!!
0:00 Intro
0:44 Adrenergic neuron
3:01 Adrenergic receptors
3:45 Alpha receptors
6:21 Beta receptors
8:22 Adrenergic agonists
10:20 Direct-acting agonists
15:53 Indirect-acting agonists
16:37 Mixed-action agonists
- published: 21 Sep 2016
- views: 2160755
4:48
Adrenergic Drugs - Pharmacology, Animation
- Order: Reorder
- Duration: 4:48
- Uploaded Date: 22 Jun 2020
- views: 311354
(USMLE topics) Adrenergic receptors and drugs, agonists and antagonists, mechanisms of action.
Purchase a license to download a non-watermarked version of thi...
(USMLE topics) Adrenergic receptors and drugs, agonists and antagonists, mechanisms of action.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com
Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images.
Voice by: Ashley Fleming
©Alila Medical Media. All rights reserved.
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Adrenergic drugs are medications that stimulate (sympathomimetic) or inhibit (sympatholytic) adrenergic receptors. Adrenergic receptors mediate the action of noradrenaline, also known as norepinephrine; and adrenaline, also known as epinephrine. Adrenergic neurotransmission is responsible for the body’s sympathetic response - the “fight or flight” state - which dilates pupils, increases heart rate and respiratory rate, diverts blood flow to the muscles, inhibits activities that are not essential in emergency, and releases stored energy. Adrenergic receptors are also active in the central nervous system, in processes such as memory and alertness.
There are several types of adrenergic receptors, all of which are G-protein coupled, but they differ in several aspects:
- They couple with different G-proteins, leading to different downstream signalings, and hence different cellular responses.
- They differ in sensitivity to different drugs.
- While several receptors may coexist in the same tissue, there is usually one that predominates and is mainly responsible for the tissue’s adrenergic response. For example: alpha-1 receptor predominates in peripheral vascular smooth muscle – its activation induces vasoconstriction; beta-1 is prominent in the heart - it increases heart rate and cardiac contractility when activated; beta-2 activation results in bronchodilation in the lungs; and alpha-2 reduces sympathetic outflow in the brainstem. Alpha-2 can also act at the pre-synaptic neuron, where it inhibits neurotransmitter release, as a feedback mechanism.
Most adrenergic drugs act directly at the receptors, only a few act indirectly by promoting neurotransmitter release, or by preventing its degradation.
Non-specific drugs are those that can bind to several receptors. Non-specific agonists include epinephrine, norepinephrine and dopamine. Their relative activity via different receptors depends on the dose administered. For example, epinephrine has a greater affinity for beta receptors in small doses, but can bind to alpha receptors equally well at higher doses. At low levels, epinephrine preferentially binds to vascular beta-2-receptor and causes vasodilation. As the concentration of epinephrine increases, lower affinity alpha-receptors begin to bind epinephrine, producing vasoconstriction. Because there are more alpha-receptors than beta-receptors in peripheral blood vessels, alpha-mediated vasoconstriction eventually overrides beta-mediated vasodilation. Thus, at higher pharmacologic doses, epinephrine induces vasoconstriction via alpha receptors; increases heart rate, cardiac contractility via beta-1 receptor; and dilates bronchi via beta-2 receptor. Epinephrine is the treatment of choice for cardiac arrest, anaphylaxis, and severe croup.
Specific drugs target only a certain type of receptor:
- Alpha-1 specific agonists induce smooth muscle contraction and are used as vasopressors for treatment of shock, hypotension; as nasal decongestants; or to dilate pupils.
Alpha-1 antagonists, on the other hand, are used to treat hypertension, and to relax smooth muscle within the prostate for treatment of benign prostatic hyperplasia.
- Alpha-2 agonists act on alpha-2 receptors in the brainstem to reduce sympathetic tone, and are used to treat hypertension. Stimulation of peripheral alpha-2 receptors may initially cause vasoconstriction, but it is quickly overridden by the central effect.
- Beta-1 agonists increase heart rate and contractility, and are indicated for treatment of cardiogenic shock and heart failure.
- Beta-2 agonists relax smooth muscles. They are used to dilate bronchi, for treatment of asthma, obstructive pulmonary disease, and anaphylaxis. Some are used to relax uterine smooth muscle to delay preterm birth.
Beta antagonists, or beta blockers, are used for the treatment of hypertension, ischemic heart disease, obstructive cardiomyopathy, and arrhythmias.
https://wn.com/Adrenergic_Drugs_Pharmacology,_Animation
(USMLE topics) Adrenergic receptors and drugs, agonists and antagonists, mechanisms of action.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com
Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images.
Voice by: Ashley Fleming
©Alila Medical Media. All rights reserved.
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Adrenergic drugs are medications that stimulate (sympathomimetic) or inhibit (sympatholytic) adrenergic receptors. Adrenergic receptors mediate the action of noradrenaline, also known as norepinephrine; and adrenaline, also known as epinephrine. Adrenergic neurotransmission is responsible for the body’s sympathetic response - the “fight or flight” state - which dilates pupils, increases heart rate and respiratory rate, diverts blood flow to the muscles, inhibits activities that are not essential in emergency, and releases stored energy. Adrenergic receptors are also active in the central nervous system, in processes such as memory and alertness.
There are several types of adrenergic receptors, all of which are G-protein coupled, but they differ in several aspects:
- They couple with different G-proteins, leading to different downstream signalings, and hence different cellular responses.
- They differ in sensitivity to different drugs.
- While several receptors may coexist in the same tissue, there is usually one that predominates and is mainly responsible for the tissue’s adrenergic response. For example: alpha-1 receptor predominates in peripheral vascular smooth muscle – its activation induces vasoconstriction; beta-1 is prominent in the heart - it increases heart rate and cardiac contractility when activated; beta-2 activation results in bronchodilation in the lungs; and alpha-2 reduces sympathetic outflow in the brainstem. Alpha-2 can also act at the pre-synaptic neuron, where it inhibits neurotransmitter release, as a feedback mechanism.
Most adrenergic drugs act directly at the receptors, only a few act indirectly by promoting neurotransmitter release, or by preventing its degradation.
Non-specific drugs are those that can bind to several receptors. Non-specific agonists include epinephrine, norepinephrine and dopamine. Their relative activity via different receptors depends on the dose administered. For example, epinephrine has a greater affinity for beta receptors in small doses, but can bind to alpha receptors equally well at higher doses. At low levels, epinephrine preferentially binds to vascular beta-2-receptor and causes vasodilation. As the concentration of epinephrine increases, lower affinity alpha-receptors begin to bind epinephrine, producing vasoconstriction. Because there are more alpha-receptors than beta-receptors in peripheral blood vessels, alpha-mediated vasoconstriction eventually overrides beta-mediated vasodilation. Thus, at higher pharmacologic doses, epinephrine induces vasoconstriction via alpha receptors; increases heart rate, cardiac contractility via beta-1 receptor; and dilates bronchi via beta-2 receptor. Epinephrine is the treatment of choice for cardiac arrest, anaphylaxis, and severe croup.
Specific drugs target only a certain type of receptor:
- Alpha-1 specific agonists induce smooth muscle contraction and are used as vasopressors for treatment of shock, hypotension; as nasal decongestants; or to dilate pupils.
Alpha-1 antagonists, on the other hand, are used to treat hypertension, and to relax smooth muscle within the prostate for treatment of benign prostatic hyperplasia.
- Alpha-2 agonists act on alpha-2 receptors in the brainstem to reduce sympathetic tone, and are used to treat hypertension. Stimulation of peripheral alpha-2 receptors may initially cause vasoconstriction, but it is quickly overridden by the central effect.
- Beta-1 agonists increase heart rate and contractility, and are indicated for treatment of cardiogenic shock and heart failure.
- Beta-2 agonists relax smooth muscles. They are used to dilate bronchi, for treatment of asthma, obstructive pulmonary disease, and anaphylaxis. Some are used to relax uterine smooth muscle to delay preterm birth.
Beta antagonists, or beta blockers, are used for the treatment of hypertension, ischemic heart disease, obstructive cardiomyopathy, and arrhythmias.
- published: 22 Jun 2020
- views: 311354
20:17
Classification of Adrenergic Drugs || Individual Adrenergic Drugs || Sympathomimetics Pharmacology
- Order: Reorder
- Duration: 20:17
- Uploaded Date: 20 Sep 2022
- views: 28529
📝 Find notes here: https://www.nonstopneuron.com/post/classification-of-adrenergic-drugs
🌐 Explore our entire animation video library: https://www.nonstopneuron...
📝 Find notes here: https://www.nonstopneuron.com/post/classification-of-adrenergic-drugs
🌐 Explore our entire animation video library: https://www.nonstopneuron.com/
● Follow me at:
• Instagram: https://www.instagram.com/NonstopNeuron/
• Facebook: https://www.facebook.com/NonstopNeuron
Classification of Adrenergic Drugs
Classification of adrenergic drugs includes endogenous catecholamines, drugs that act directly on the receptors, indirectly acting drugs, and mixed-acting sympathomimetics. Endogenous catecholamines are epinephrine, norepinephrine, and dopamine. Selective α1 agonists are phenylephrine, methoxamine, and midodrine. Selective α2 agonists are clonidine, methyldopa, guanfacine, guanabenz, moxonidine, rilmenidine, dexmedetomidine, tizanidine, naphazoline, xylometazoline, oxymetazoline, apraclonidine, and brimonidine. Isoproterenol is a nonselective β agonist. Dobutamine is β1 subtype-selective agonist. Selective β2 agonists are salbutamol, terbutaline, salmeterol, formoterol, ritodrine and isoxuprine. Amphetamine-like drugs, which increase transmitter release are amphetamine, methamphetamine, methylphenidate, modafinil, and tyramine. Catecholamine reuptake inhibitors are imipramine, amitriptyline, sibutramine, duloxetine, milnacipran, atomoxetine, and cocaine. Mixed actin sympathomimetic drugs are ephedrine, mephentermine, and pseudoephedrine.
Dr Vipul Navadiya
Chapters:
00:00 Introduction
01:21 Endogenous Catecholamines
05:40 Direct Acting Sympathomimetics
12:13 Indirect Acting Sympathomimetics
16:51 Mixed Acting Sympathomimetics
17:55 Summary
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.
https://wn.com/Classification_Of_Adrenergic_Drugs_||_Individual_Adrenergic_Drugs_||_Sympathomimetics_Pharmacology
📝 Find notes here: https://www.nonstopneuron.com/post/classification-of-adrenergic-drugs
🌐 Explore our entire animation video library: https://www.nonstopneuron.com/
● Follow me at:
• Instagram: https://www.instagram.com/NonstopNeuron/
• Facebook: https://www.facebook.com/NonstopNeuron
Classification of Adrenergic Drugs
Classification of adrenergic drugs includes endogenous catecholamines, drugs that act directly on the receptors, indirectly acting drugs, and mixed-acting sympathomimetics. Endogenous catecholamines are epinephrine, norepinephrine, and dopamine. Selective α1 agonists are phenylephrine, methoxamine, and midodrine. Selective α2 agonists are clonidine, methyldopa, guanfacine, guanabenz, moxonidine, rilmenidine, dexmedetomidine, tizanidine, naphazoline, xylometazoline, oxymetazoline, apraclonidine, and brimonidine. Isoproterenol is a nonselective β agonist. Dobutamine is β1 subtype-selective agonist. Selective β2 agonists are salbutamol, terbutaline, salmeterol, formoterol, ritodrine and isoxuprine. Amphetamine-like drugs, which increase transmitter release are amphetamine, methamphetamine, methylphenidate, modafinil, and tyramine. Catecholamine reuptake inhibitors are imipramine, amitriptyline, sibutramine, duloxetine, milnacipran, atomoxetine, and cocaine. Mixed actin sympathomimetic drugs are ephedrine, mephentermine, and pseudoephedrine.
Dr Vipul Navadiya
Chapters:
00:00 Introduction
01:21 Endogenous Catecholamines
05:40 Direct Acting Sympathomimetics
12:13 Indirect Acting Sympathomimetics
16:51 Mixed Acting Sympathomimetics
17:55 Summary
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.
- published: 20 Sep 2022
- views: 28529
12:27
2.Sympathomimetic Drugs - Directly Acting sympathomimetic Drugs (Part 1)
- Order: Reorder
- Duration: 12:27
- Uploaded Date: 25 Dec 2020
- views: 30387
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- ...
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash
2.Sympathomimetic Drugs - Directly Acting sympathomimetic Drugs (Part 1)
Sympathomimetics are substances that mimic or modify the actions of endogenous catecholamines of the sympathetic nervous system. Direct agonists directly activate adrenergic receptors while indirect agonists enhance the actions of endogenous catecholamines. Sympathomimetics stimulates alpha-1 adrenergic receptors, beta-adrenergic receptors, and dopamine (D) receptors in various target tissues, such as the eyes, heart, and vascular smooth muscle. The clinical indications for sympathomimetics are broad and include asthma, heart failure, shock, and anaphylaxis. Side effects include hypertension, sinus tachycardia, and skeletal muscle tremor.
#sympathomimetics #sympathomimetic #sympathomimeticdrugs #sympathomimeticagents #sympathomimeticspharmacology #mbbspharmacology #anspharmacology #adrenergicpharmacology ##pharmacologyofans #autonomicpharmacology #autonomicnervoussystem #pharmacology #directlyactingsympathomimeticdrugs #directlyactingsympathomimetics
https://wn.com/2.Sympathomimetic_Drugs_Directly_Acting_Sympathomimetic_Drugs_(Part_1)
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash
2.Sympathomimetic Drugs - Directly Acting sympathomimetic Drugs (Part 1)
Sympathomimetics are substances that mimic or modify the actions of endogenous catecholamines of the sympathetic nervous system. Direct agonists directly activate adrenergic receptors while indirect agonists enhance the actions of endogenous catecholamines. Sympathomimetics stimulates alpha-1 adrenergic receptors, beta-adrenergic receptors, and dopamine (D) receptors in various target tissues, such as the eyes, heart, and vascular smooth muscle. The clinical indications for sympathomimetics are broad and include asthma, heart failure, shock, and anaphylaxis. Side effects include hypertension, sinus tachycardia, and skeletal muscle tremor.
#sympathomimetics #sympathomimetic #sympathomimeticdrugs #sympathomimeticagents #sympathomimeticspharmacology #mbbspharmacology #anspharmacology #adrenergicpharmacology ##pharmacologyofans #autonomicpharmacology #autonomicnervoussystem #pharmacology #directlyactingsympathomimeticdrugs #directlyactingsympathomimetics
- published: 25 Dec 2020
- views: 30387
4:11:29
Adrenergic Drugs Part 1 | Pharmacology | Dr Najeeb👨⚕️
- Order: Reorder
- Duration: 4:11:29
- Uploaded Date: 26 Mar 2023
- views: 110128
#drnajeeb #pharmacology #medicines #adrenergic #drugs # adrenergicdrugs
Adrenergic Drugs Part 1 | Pharmacology | Dr Najeeb👨⚕️
Like this video? Sign up now on...
#drnajeeb #pharmacology #medicines #adrenergic #drugs # adrenergicdrugs
Adrenergic Drugs Part 1 | Pharmacology | Dr Najeeb👨⚕️
Like this video? Sign up now on our website at https://www.DrNajeebLectures.com
to access 1000+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $59 ONLY!
Sign up now on our website at https://members.drnajeeblectures.com/#!/register-fast
---------------------------------------------------------------------------------------------------------------------------
Why sign up for premium membership? Here's why!
Membership Features for premium website members.
1. More than 1000+ Medical Lectures.
2. Basic Medical Sciences & Clinical Medicine.
3. Mobile-friendly interface with android and iOS apps.
4. English subtitles and new videos every week.
5. Download option for offline video playback.
6. Fanatic customer support and that's 24/7.
7. Fast video playback option to learn faster.
8. Trusted by over 2M+ students in 190 countries.
---------------------------------------------------------------------------------------------------------------------------
▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
00:00:00 Introduction, Autonomic NS pharmacology, Subtypes
00:05:25 Neurophysiology of sympathetic and parasympathetic nervous system
00:10:30 How sympathetic nervous system activated? Function of hypothalamus and limbic system
00:16:20 Polyneuronal sympathetic descending pathway
00:19:16 Sympathetic outflow, Adrenergic and non-adrenergic receptors, acetylcholine, nor epinephrine
00:25:45 Recap
00:26:15 How nerve endings work? Neurotransmitter synthesis, storage and release
00:30:12 Synthesis of norepinephrine (Tyrosine, DOPA, Dopamine, Norepinephrine)
00:46:46 How norepinephrine release? Depolarization sensitive Calcium channel
00:55:15 Inhibitory function of Alpha 2 receptor
00:58:31 What happens to norepinephrine after its release?
01:07:16 Drugs effect on nerve endings of adrenergic transmission (Metyrosine, Reserpine, Guanethidine, Alpha methyl dopa)
01:29:50 Concept of agonist, antagonist, partial agonist, mixed agonist and antagonist
01:39:38 Adrenoceptor Blocker or antagonist (sympatholytic drugs)
Alpha blockers
Beta blockers
01:47:56 Recap
01:50:14 sympathomimetic Drugs and its classification
01:53:21 A) Direct acting sympathomimetic drugs
02:11:25 B) Indirect acting sympathomimetic drugs (cocaine, TCA)
02:22:40 Distribution of adrenergic receptors on different body tissues
02:43:23 Changes in body under the influence of adrenergic response
02:44:17 a) Changes in hairs
02:46:41 b) Changes in eyes (pupils, ciliary muscles, lens etc.)
03:01:12 c) Changes in GIT
---------------------------------------------------------------------------------------------------------------------------
Adrenergic Agonists are drugs that lead to stimulation of the adrenergic receptors. In doing so, adrenergic agonists generally simulate activation of certain aspects of the sympathetic nervous system and are thus also known as "sympathomimetics".
Mechanisms of Action
Overview
A diverse variety of sympathomimetics exist which operate using distinct mechanisms. In general, these compounds are divided into direct-acting, indirect-acting, or mixed-acting agonists depending on whether they directly activate adrenergic receptors or do so by indirect mechanisms
Direct-acting Agonists
Direct agonists physically bind the adrenergic receptor and simulate binding of an endogenous ligand. These compounds can be highly specific, activating only certain subtypes of receptors, or can be rather promiscuous.
Indirect-acting Agonists
Indirect agonists do not physically bind adrenergic receptors. Instead, these compounds indirectly lead to receptor activation through a variety of possible mechanisms which include promoting release of endogenously-stored norepinephrine from presynaptic terminals as well as inhibition of norepinephrine re-uptake and degradation from the synapse.
Mixed-acting Agonists
Mixed agonists simply refer to those compounds which display both direct and indirect mechanisms of actions. As such, these compounds directly bind adrenergic receptors but also promote the indirect mechanisms described above.
---------------------------------------------------------------------------------------------------------------------------
Join this channel to get access to perks:
Sign up now on our website at https://members.drnajeeblectures.com/#!/register-fast
https://www.youtube.com/channel/UCPHpx55tgrbm8FrYYCflAHw/join
Follow us on Facebook :- https://www.facebook.com/DrNajeeb/
Follow us on Instagram :- https://www.instagram.com/drnajeeblectures/
https://wn.com/Adrenergic_Drugs_Part_1_|_Pharmacology_|_Dr_Najeeb👨⚕️
#drnajeeb #pharmacology #medicines #adrenergic #drugs # adrenergicdrugs
Adrenergic Drugs Part 1 | Pharmacology | Dr Najeeb👨⚕️
Like this video? Sign up now on our website at https://www.DrNajeebLectures.com
to access 1000+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $59 ONLY!
Sign up now on our website at https://members.drnajeeblectures.com/#!/register-fast
---------------------------------------------------------------------------------------------------------------------------
Why sign up for premium membership? Here's why!
Membership Features for premium website members.
1. More than 1000+ Medical Lectures.
2. Basic Medical Sciences & Clinical Medicine.
3. Mobile-friendly interface with android and iOS apps.
4. English subtitles and new videos every week.
5. Download option for offline video playback.
6. Fanatic customer support and that's 24/7.
7. Fast video playback option to learn faster.
8. Trusted by over 2M+ students in 190 countries.
---------------------------------------------------------------------------------------------------------------------------
▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
00:00:00 Introduction, Autonomic NS pharmacology, Subtypes
00:05:25 Neurophysiology of sympathetic and parasympathetic nervous system
00:10:30 How sympathetic nervous system activated? Function of hypothalamus and limbic system
00:16:20 Polyneuronal sympathetic descending pathway
00:19:16 Sympathetic outflow, Adrenergic and non-adrenergic receptors, acetylcholine, nor epinephrine
00:25:45 Recap
00:26:15 How nerve endings work? Neurotransmitter synthesis, storage and release
00:30:12 Synthesis of norepinephrine (Tyrosine, DOPA, Dopamine, Norepinephrine)
00:46:46 How norepinephrine release? Depolarization sensitive Calcium channel
00:55:15 Inhibitory function of Alpha 2 receptor
00:58:31 What happens to norepinephrine after its release?
01:07:16 Drugs effect on nerve endings of adrenergic transmission (Metyrosine, Reserpine, Guanethidine, Alpha methyl dopa)
01:29:50 Concept of agonist, antagonist, partial agonist, mixed agonist and antagonist
01:39:38 Adrenoceptor Blocker or antagonist (sympatholytic drugs)
Alpha blockers
Beta blockers
01:47:56 Recap
01:50:14 sympathomimetic Drugs and its classification
01:53:21 A) Direct acting sympathomimetic drugs
02:11:25 B) Indirect acting sympathomimetic drugs (cocaine, TCA)
02:22:40 Distribution of adrenergic receptors on different body tissues
02:43:23 Changes in body under the influence of adrenergic response
02:44:17 a) Changes in hairs
02:46:41 b) Changes in eyes (pupils, ciliary muscles, lens etc.)
03:01:12 c) Changes in GIT
---------------------------------------------------------------------------------------------------------------------------
Adrenergic Agonists are drugs that lead to stimulation of the adrenergic receptors. In doing so, adrenergic agonists generally simulate activation of certain aspects of the sympathetic nervous system and are thus also known as "sympathomimetics".
Mechanisms of Action
Overview
A diverse variety of sympathomimetics exist which operate using distinct mechanisms. In general, these compounds are divided into direct-acting, indirect-acting, or mixed-acting agonists depending on whether they directly activate adrenergic receptors or do so by indirect mechanisms
Direct-acting Agonists
Direct agonists physically bind the adrenergic receptor and simulate binding of an endogenous ligand. These compounds can be highly specific, activating only certain subtypes of receptors, or can be rather promiscuous.
Indirect-acting Agonists
Indirect agonists do not physically bind adrenergic receptors. Instead, these compounds indirectly lead to receptor activation through a variety of possible mechanisms which include promoting release of endogenously-stored norepinephrine from presynaptic terminals as well as inhibition of norepinephrine re-uptake and degradation from the synapse.
Mixed-acting Agonists
Mixed agonists simply refer to those compounds which display both direct and indirect mechanisms of actions. As such, these compounds directly bind adrenergic receptors but also promote the indirect mechanisms described above.
---------------------------------------------------------------------------------------------------------------------------
Join this channel to get access to perks:
Sign up now on our website at https://members.drnajeeblectures.com/#!/register-fast
https://www.youtube.com/channel/UCPHpx55tgrbm8FrYYCflAHw/join
Follow us on Facebook :- https://www.facebook.com/DrNajeeb/
Follow us on Instagram :- https://www.instagram.com/drnajeeblectures/
- published: 26 Mar 2023
- views: 110128
11:58
Sympathomimetics or Adrenergic Receptor Agonists pharmacology MADE EASY!
- Order: Reorder
- Duration: 11:58
- Uploaded Date: 26 Aug 2019
- views: 62346
Sympathomimetics/ Adrenergic agonists are substances that mimic or modify the actions of endogenous catecholamines of the sympathetic nervous system. Direct ago...
Sympathomimetics/ Adrenergic agonists are substances that mimic or modify the actions of endogenous catecholamines of the sympathetic nervous system. Direct agonists directly activate adrenergic receptors while indirect agonists enhance the actions of endogenous catecholamines.
https://wn.com/Sympathomimetics_Or_Adrenergic_Receptor_Agonists_Pharmacology_Made_Easy
Sympathomimetics/ Adrenergic agonists are substances that mimic or modify the actions of endogenous catecholamines of the sympathetic nervous system. Direct agonists directly activate adrenergic receptors while indirect agonists enhance the actions of endogenous catecholamines.
- published: 26 Aug 2019
- views: 62346
PLAYLIST TIME:
PLAYLIST TIME:
8:00
1.Sympathomimetic drugs Introduction - ANS Pharmacology
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻...
published: 25 Dec 2020
1.Sympathomimetic drugs Introduction - ANS Pharmacology
1.Sympathomimetic drugs Introduction - ANS Pharmacology
- Report rights infringement
- published: 25 Dec 2020
- views: 81339
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash
1.Sympathomimetic drugs Introduction - ANS Pharmacology
Sympathomimetics are substances that mimic or modify the actions of endogenous catecholamines of the sympathetic nervous system. Direct agonists directly activate adrenergic receptors while indirect agonists enhance the actions of endogenous catecholamines. Sympathomimetics stimulates alpha-1 adrenergic receptors, beta-adrenergic receptors, and dopamine (D) receptors in various target tissues, such as the eyes, heart, and vascular smooth muscle. The clinical indications for sympathomimetics are broad and include asthma, heart failure, shock, and anaphylaxis. Side effects include hypertension, sinus tachycardia, and skeletal muscle tremor.
#sympathomimetics #sympathomimetic #sympathomimeticdrugs #sympathomimeticagents #sympathomimeticspharmacology #mbbspharmacology #anspharmacology #adrenergicpharmacology ##pharmacologyofans #autonomicpharmacology #autonomicnervoussystem #pharmacology
1:05:39
Sympathomimetics (Adrenergic Agonists)—Epinephrine, Norepinephrine - Alpha & Beta Receptors
Sympathomimetics (Adrenergic Agonists)—Catecholamines (Epinephrine, Norepinephrine, Dopami...
published: 25 Nov 2023
Sympathomimetics (Adrenergic Agonists)—Epinephrine, Norepinephrine - Alpha & Beta Receptors
Sympathomimetics (Adrenergic Agonists)—Epinephrine, Norepinephrine - Alpha & Beta Receptors
- Report rights infringement
- published: 25 Nov 2023
- views: 24221
Sympathomimetics (Adrenergic Agonists)—Catecholamines (Epinephrine, Norepinephrine, Dopamine), Alpha & Beta Receptors…Alpha adrenergic receptors (alpha 1, alpha 2), beta adrenergic (beta 1, beta 2, beta 3). receptors. Sympathetic autonomic nervous system (SANS). Alpha agonists, alpha antagonists (alpha blockers), beta agonists, beta antagonists (beta blockers). Autonomic pharmacology, Asthma treatment, Respiratory pharmacology, cardiovascular pharmacology, Hypertension pharmacology.
💊🦠 Antibiotics Course: https://www.medicosisperfectionalis.com/products/courses/antibiotics/
💦 🐳 Kidney Physiology Course: https://www.medicosisperfectionalis.com/products/
🤰 ObGyn Highyields Course: https://www.medicosisperfectionalis.com/
🚨 Emergency Medicine HighYields Course: https://www.medicosisperfectionalis.com/
😷 Surgery HighYields Course: https://www.medicosisperfectionalis.com/
💊 📛 Toxicology Course: https://www.medicosisperfectionalis.com/
❤️ Cardiac Pharmacology Course: https://www.medicosisperfectionalis.com/
🧪Acid-Base Course: https://www.medicosisperfectionalis.com/products/
🧠 Autonomic Pharmacology Course: www.medicosisperfectionalis.com/
🧪 Electrolytes Course: https://www.medicosisperfectionalis.com/
🍱 Endocrine Pharmacology Course: https://www.medicosisperfectionalis.com/products/
🧠 CNS Pharmacology Course: https://www.medicosisperfectionalis.com/
💊 General Pharmacology (Pharmacokinetics and Pharmacodynamics): https://www.medicosisperfectionalis.com/
📝 Download my handwritten notes: www.medicosisperfectionalis.com/
⁉️ Questions and Answers: https://www.medicosisperfectionalis.com/
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG
🎁Free Stuff: https://www.medicosisperfectionalis.com/
💊 Pharmacology Lectures: https://www.medicosisperfectionalis.com/
YouTube PLAYLISTS:
► 🧠 Physiology Playlist: https://www.youtube.com/watch?v=6qk_LTVXZ2w&list;=PLYcLrRDaR8_eAjmngd289ghWijs2wfqnj&index;=2&t;=0s
🧫 🦠 Microbiology and Infectious Diseases Playlist: https://youtube.com/playlist?list=PLYcLrRDaR8_ftu9ms-ytDewlhJxYNuIYo
► 🩸 Hematology videos: https://www.youtube.com/playlist?list=PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU
► 💪 Rheumatology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_ckdsow-7buX1rIzIEKfxZQ
► ❤️ Cardiac Pharmacology: https://www.youtube.com/playlist?list=PLYcLrRDaR8_e3pM6ifeZDfNPlE3K4KF3J
► Biochemistry 🧪 : https://youtube.com/playlist?list=PLYcLrRDaR8_c2LBpF_OYvwijOok7ae96N
►🔥Chemistry: https://youtube.com/playlist?list=PLYcLrRDaR8_e4MrgwcOjbt3mS4nUbSs8w
► 🙌 Support me on cash app: https://cash.app/$medicosis/
► Support me on Stripe: https://donate.stripe.com/3cs02Hb9ca2k4c8fYZ
► 😍 Support me on Patreon: https://www.patreon.com/medicosis/
► Support me on Venmo: Venmo: https://venmo.com/medicosis
► 🥰 Support me on PayPal: https://www.paypal.me/perfectionalis/
► ☕️ Buy me a Coffee: https://www.buymeacoffee.com/medicosis/
► 😚 Join my Channel on YouTube: https://www.youtube.com/channel/UCl-J-ovSJhA3or73Q2uVpow/join
--If you’ve joined my channel on youtube (the join button that's next to the subscribe button), then go to the "membership tab" and you will find some member-only posts/videos.
► 👨🏫 All of my premium courses are ON SALE: https://www.medicosisperfectionalis.com/
📚 Recommended Books: https://www.amazon.com/shop/medicosisperfectionalis/
► ❓If you have any questions, please email me at: medicosisperfectionalis@gmail.com
🗳 Complete the Survey: https://airtable.com/shrYWjvabooT7DrcG/
►Website: https://www.medicosisperfectionalis.com/
►Patreon: https://www.patreon.com/medicosis/
►YouTube: https://www.youtube.com/c/MedicosisPerfectionalis or:
► Like my page on Facebook https://www.facebook.com/medicosis/
►Follow us on Instagram here: https://www.instagram.com/medicosisperfectionalis/
►PayPal: https://www.paypal.me/perfectionalis/
►Venmo: @medicosis
►Facebook: https://www.facebook.com/medicosis/
►Twitter: https://www.twitter.com/medicosis/
►SoundCloud: https://soundcloud.com/medicosis/
►TikTok: www.tiktok.com/@medicosisp/
►LinkedIn: linkedin.com/in/medicosis-perfectionalis-873886197/
►Snapchat: https://www.snapchat.com/add/medicosis/
►Pinterest: https://www.pinterest.com/medicosisperfectionalis/
►Rumble: https://rumble.com/user/MedicosisPerfectionalis/
► Tumblr: https://medicosis.tumblr.com/
Thank you so much for supporting my channel! Love ❤️& Happy studying!!
😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/
📱Save on your mobile phone bill: http://fbuy.me/q6bMj
📊 My favorite Productivity App: https://airtable.com/invite/r/2zH40fus/
🙋♀️ Qbank (TrueLearn): https://truelearn.referralrock.com/l/MEDICOSIS/
🙌 Support the channel: https://donate.stripe.com/3cs02Hb9ca2k4c8fYZ
1:45:41
Autonomic Pharmacology | Adrenergic Agonists
Official Ninja Nerd Website: https://ninjanerd.org
You can find the NOTES and ILLUSTRATION...
published: 23 Sep 2022
Autonomic Pharmacology | Adrenergic Agonists
Autonomic Pharmacology | Adrenergic Agonists
- Report rights infringement
- published: 23 Sep 2022
- views: 257514
Official Ninja Nerd Website: https://ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
https://www.ninjanerd.org/lecture/autonomic-pharmacology-adrenergic-agonists
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Adrenergic Agonists within our short series on Autonomic Pharmacology. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Adrenergic Agonists Introduction
1:06 Adrenergic Neurons and Receptors
19:32 Adrenergic Target Organ Effects
30:34 Alpha 1 Agonists
39:38 Alpha 2 Agonists
47:48 Beta 1 Agonists
51:42 Beta 1 + 2 Agonists
56:19 Beta 2 Agonists
1:02:47 Beta 3 Agonists
1:04:07 Alpha + Beta Agonists
1:13:17 Epinephrine + Dopamine
1:22:30 Norepinephrine Graphical Representation
1:29:48 Epinephrine Graphical Representation
1:34:49 Isoproterenol Graphical Representation
1:39:11 Adrenergic Agonists Practice Problems
1:45:20 Comment, Like, SUBSCRIBE!
Supplemental Lecture: Neurology | Adrenergic Receptors -- https://youtu.be/ZLW8V7bwW4U
Pharmacology Source:
Whalen, Karen. Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). Wolters Kluwer Health. Kindle Edition.
Join this channel to get access to perks:
https://www.youtube.com/channel/UC6QYFutt9cluQ3uSM963_KQ/join
APPAREL |
https://shop.ninjanerd.org
https://www.amazon.com/s?k=ninja+nerd&ref;=nb_sb_noss_2
PODCAST |
Apple Podcast: https://podcasts.apple.com/us/podcast/ninja-nerd/id1611469997
Spotify: https://open.spotify.com/show/2ZDXoakATwCgkRH3EpCZYu?si=922326f893f4437e
Google Podcast: https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5idXp6c3Byb3V0LmNvbS8xOTQ1NjU1LnJzcw==
DONATE
PAYPAL | https://www.paypal.com/paypalme/ninjanerdscience
SOCIAL MEDIA
FACEBOOK | https://www.facebook.com/NinjaNerdlectures
INSTAGRAM | https://www.instagram.com/ninjanerdlectures
TWITTER | https://twitter.com/ninjanerdsci
@NinjaNerdSci
DISCORD | https://discord.gg/3srTG4dngW
#ninjanerd #pharmacology #AdrenergicAgonists
4:59
Sympathomimetics Mechanism and Side Effects
Sympathomimetics, also known as adrenergic agonists or adrenergic agonist drugs, are a cla...
published: 28 May 2021
Sympathomimetics Mechanism and Side Effects
Sympathomimetics Mechanism and Side Effects
- Report rights infringement
- published: 28 May 2021
- views: 5631
Sympathomimetics, also known as adrenergic agonists or adrenergic agonist drugs, are a class of medications that mimic the effects of the sympathetic nervous system's neurotransmitters, particularly norepinephrine and epinephrine (adrenaline). The sympathetic nervous system is responsible for the "fight or flight" response in the body, which prepares the body for stressful situations by increasing heart rate, dilating airways, redirecting blood flow to the muscles, and more. Sympathomimetic drugs can either directly activate adrenergic receptors or increase the release of norepinephrine and epinephrine.
These drugs have a wide range of therapeutic applications due to their ability to stimulate various physiological responses. Some common uses of sympathomimetics include:
1. Cardiovascular Conditions: Sympathomimetics can be used to treat conditions like low blood pressure (hypotension) and cardiac arrest by increasing heart rate and improving blood flow.
2. Asthma and Bronchospasm: Sympathomimetic drugs like albuterol are used to dilate bronchial passages in conditions such as asthma and chronic obstructive pulmonary disease (COPD), helping to relieve breathing difficulties.
3. Nasal Congestion: Decongestant medications containing sympathomimetics, like pseudoephedrine, can help alleviate nasal congestion by narrowing blood vessels in the nasal passages.
4. Allergic Reactions: Epinephrine (adrenaline) is used as an emergency treatment for severe allergic reactions (anaphylaxis). It can quickly reverse the symptoms of anaphylaxis, including airway constriction, low blood pressure, and hives.
5. Attention Deficit Hyperactivity Disorder (ADHD): Some sympathomimetics, like methylphenidate and amphetamine-based drugs, are used to manage symptoms of ADHD by increasing focus and reducing hyperactivity.
6. Weight Loss: Certain sympathomimetics can act as appetite suppressants and stimulate metabolism, making them potential components of weight loss medications.
7. Local Anesthesia: Epinephrine is sometimes added to local anesthetic solutions to prolong the effects of the anesthetic and reduce bleeding at the site.
8. Shock and Hypotension: In emergency medicine, sympathomimetics can be used to raise blood pressure in cases of shock or severe hypotension.
It's important to note that sympathomimetic drugs can have various side effects and contraindications. Common side effects can include increased heart rate, elevated blood pressure, anxiety, restlessness, insomnia, and tremors. Some individuals may be more sensitive to these effects than others. Also, prolonged or excessive use of sympathomimetics can lead to tolerance, dependence, and potential abuse.
Due to their potential to impact cardiovascular function and other physiological processes, sympathomimetics should be used under the guidance and prescription of a healthcare professional. The specific drug chosen, dosage, and duration of treatment will depend on the medical condition being treated and the patient's individual health profile.
17:51
Pharmacology - ADRENERGIC RECEPTORS & AGONISTS (MADE EASY)
👉📖 READY TO ACE YOUR EXAM? 📚 GET STUDY NOTES ON PATREON!
https://www.patreon.com/speedphar...
published: 21 Sep 2016
Pharmacology - ADRENERGIC RECEPTORS & AGONISTS (MADE EASY)
Pharmacology - ADRENERGIC RECEPTORS & AGONISTS (MADE EASY)
- Report rights infringement
- published: 21 Sep 2016
- views: 2160755
👉📖 READY TO ACE YOUR EXAM? 📚 GET STUDY NOTES ON PATREON!
https://www.patreon.com/speedpharmacology
Adrenergic agonists are a group of drugs that stimulate alpha and beta adrenergic receptors by mimicking the action of naturally occurring catecholamines such as norepinephrine, epinephrine and dopamine. This pharmacology lecture covers topics such as mechanism of action of adrenergic agonists; catecholamines, noncatecholamines, direct acting, indirect acting, mixed action; location and function of alpha and beta receptors. Adrenergic agonists mentioned include: Epinephrine, Norepinephrine, Dopamine, Oxymetazoline, Phenylephrine, Clonidine, Dobutamine, Albuterol, Terbutaline, Salmeterol, Formoterol, Mirabegron, Cocaine, Amphetamine, Ephedrine, Pseudoephedrine.
Thanks for watching and don't forget to SUBSCRIBE, hit the LIKE button👍 and click the BELL button🔔 for future notifications!!!
0:00 Intro
0:44 Adrenergic neuron
3:01 Adrenergic receptors
3:45 Alpha receptors
6:21 Beta receptors
8:22 Adrenergic agonists
10:20 Direct-acting agonists
15:53 Indirect-acting agonists
16:37 Mixed-action agonists
4:48
Adrenergic Drugs - Pharmacology, Animation
(USMLE topics) Adrenergic receptors and drugs, agonists and antagonists, mechanisms of act...
published: 22 Jun 2020
Adrenergic Drugs - Pharmacology, Animation
Adrenergic Drugs - Pharmacology, Animation
- Report rights infringement
- published: 22 Jun 2020
- views: 311354
(USMLE topics) Adrenergic receptors and drugs, agonists and antagonists, mechanisms of action.
Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com
Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images.
Voice by: Ashley Fleming
©Alila Medical Media. All rights reserved.
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Adrenergic drugs are medications that stimulate (sympathomimetic) or inhibit (sympatholytic) adrenergic receptors. Adrenergic receptors mediate the action of noradrenaline, also known as norepinephrine; and adrenaline, also known as epinephrine. Adrenergic neurotransmission is responsible for the body’s sympathetic response - the “fight or flight” state - which dilates pupils, increases heart rate and respiratory rate, diverts blood flow to the muscles, inhibits activities that are not essential in emergency, and releases stored energy. Adrenergic receptors are also active in the central nervous system, in processes such as memory and alertness.
There are several types of adrenergic receptors, all of which are G-protein coupled, but they differ in several aspects:
- They couple with different G-proteins, leading to different downstream signalings, and hence different cellular responses.
- They differ in sensitivity to different drugs.
- While several receptors may coexist in the same tissue, there is usually one that predominates and is mainly responsible for the tissue’s adrenergic response. For example: alpha-1 receptor predominates in peripheral vascular smooth muscle – its activation induces vasoconstriction; beta-1 is prominent in the heart - it increases heart rate and cardiac contractility when activated; beta-2 activation results in bronchodilation in the lungs; and alpha-2 reduces sympathetic outflow in the brainstem. Alpha-2 can also act at the pre-synaptic neuron, where it inhibits neurotransmitter release, as a feedback mechanism.
Most adrenergic drugs act directly at the receptors, only a few act indirectly by promoting neurotransmitter release, or by preventing its degradation.
Non-specific drugs are those that can bind to several receptors. Non-specific agonists include epinephrine, norepinephrine and dopamine. Their relative activity via different receptors depends on the dose administered. For example, epinephrine has a greater affinity for beta receptors in small doses, but can bind to alpha receptors equally well at higher doses. At low levels, epinephrine preferentially binds to vascular beta-2-receptor and causes vasodilation. As the concentration of epinephrine increases, lower affinity alpha-receptors begin to bind epinephrine, producing vasoconstriction. Because there are more alpha-receptors than beta-receptors in peripheral blood vessels, alpha-mediated vasoconstriction eventually overrides beta-mediated vasodilation. Thus, at higher pharmacologic doses, epinephrine induces vasoconstriction via alpha receptors; increases heart rate, cardiac contractility via beta-1 receptor; and dilates bronchi via beta-2 receptor. Epinephrine is the treatment of choice for cardiac arrest, anaphylaxis, and severe croup.
Specific drugs target only a certain type of receptor:
- Alpha-1 specific agonists induce smooth muscle contraction and are used as vasopressors for treatment of shock, hypotension; as nasal decongestants; or to dilate pupils.
Alpha-1 antagonists, on the other hand, are used to treat hypertension, and to relax smooth muscle within the prostate for treatment of benign prostatic hyperplasia.
- Alpha-2 agonists act on alpha-2 receptors in the brainstem to reduce sympathetic tone, and are used to treat hypertension. Stimulation of peripheral alpha-2 receptors may initially cause vasoconstriction, but it is quickly overridden by the central effect.
- Beta-1 agonists increase heart rate and contractility, and are indicated for treatment of cardiogenic shock and heart failure.
- Beta-2 agonists relax smooth muscles. They are used to dilate bronchi, for treatment of asthma, obstructive pulmonary disease, and anaphylaxis. Some are used to relax uterine smooth muscle to delay preterm birth.
Beta antagonists, or beta blockers, are used for the treatment of hypertension, ischemic heart disease, obstructive cardiomyopathy, and arrhythmias.
20:17
Classification of Adrenergic Drugs || Individual Adrenergic Drugs || Sympathomimetics Pharmacology
📝 Find notes here: https://www.nonstopneuron.com/post/classification-of-adrenergic-drugs
🌐...
published: 20 Sep 2022
Classification of Adrenergic Drugs || Individual Adrenergic Drugs || Sympathomimetics Pharmacology
Classification of Adrenergic Drugs || Individual Adrenergic Drugs || Sympathomimetics Pharmacology
- Report rights infringement
- published: 20 Sep 2022
- views: 28529
📝 Find notes here: https://www.nonstopneuron.com/post/classification-of-adrenergic-drugs
🌐 Explore our entire animation video library: https://www.nonstopneuron.com/
● Follow me at:
• Instagram: https://www.instagram.com/NonstopNeuron/
• Facebook: https://www.facebook.com/NonstopNeuron
Classification of Adrenergic Drugs
Classification of adrenergic drugs includes endogenous catecholamines, drugs that act directly on the receptors, indirectly acting drugs, and mixed-acting sympathomimetics. Endogenous catecholamines are epinephrine, norepinephrine, and dopamine. Selective α1 agonists are phenylephrine, methoxamine, and midodrine. Selective α2 agonists are clonidine, methyldopa, guanfacine, guanabenz, moxonidine, rilmenidine, dexmedetomidine, tizanidine, naphazoline, xylometazoline, oxymetazoline, apraclonidine, and brimonidine. Isoproterenol is a nonselective β agonist. Dobutamine is β1 subtype-selective agonist. Selective β2 agonists are salbutamol, terbutaline, salmeterol, formoterol, ritodrine and isoxuprine. Amphetamine-like drugs, which increase transmitter release are amphetamine, methamphetamine, methylphenidate, modafinil, and tyramine. Catecholamine reuptake inhibitors are imipramine, amitriptyline, sibutramine, duloxetine, milnacipran, atomoxetine, and cocaine. Mixed actin sympathomimetic drugs are ephedrine, mephentermine, and pseudoephedrine.
Dr Vipul Navadiya
Chapters:
00:00 Introduction
01:21 Endogenous Catecholamines
05:40 Direct Acting Sympathomimetics
12:13 Indirect Acting Sympathomimetics
16:51 Mixed Acting Sympathomimetics
17:55 Summary
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.
12:27
2.Sympathomimetic Drugs - Directly Acting sympathomimetic Drugs (Part 1)
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻...
published: 25 Dec 2020
2.Sympathomimetic Drugs - Directly Acting sympathomimetic Drugs (Part 1)
2.Sympathomimetic Drugs - Directly Acting sympathomimetic Drugs (Part 1)
- Report rights infringement
- published: 25 Dec 2020
- views: 30387
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash
2.Sympathomimetic Drugs - Directly Acting sympathomimetic Drugs (Part 1)
Sympathomimetics are substances that mimic or modify the actions of endogenous catecholamines of the sympathetic nervous system. Direct agonists directly activate adrenergic receptors while indirect agonists enhance the actions of endogenous catecholamines. Sympathomimetics stimulates alpha-1 adrenergic receptors, beta-adrenergic receptors, and dopamine (D) receptors in various target tissues, such as the eyes, heart, and vascular smooth muscle. The clinical indications for sympathomimetics are broad and include asthma, heart failure, shock, and anaphylaxis. Side effects include hypertension, sinus tachycardia, and skeletal muscle tremor.
#sympathomimetics #sympathomimetic #sympathomimeticdrugs #sympathomimeticagents #sympathomimeticspharmacology #mbbspharmacology #anspharmacology #adrenergicpharmacology ##pharmacologyofans #autonomicpharmacology #autonomicnervoussystem #pharmacology #directlyactingsympathomimeticdrugs #directlyactingsympathomimetics
4:11:29
Adrenergic Drugs Part 1 | Pharmacology | Dr Najeeb👨⚕️
#drnajeeb #pharmacology #medicines #adrenergic #drugs # adrenergicdrugs
Adrenergic Drugs ...
published: 26 Mar 2023
Adrenergic Drugs Part 1 | Pharmacology | Dr Najeeb👨⚕️
Adrenergic Drugs Part 1 | Pharmacology | Dr Najeeb👨⚕️
- Report rights infringement
- published: 26 Mar 2023
- views: 110128
#drnajeeb #pharmacology #medicines #adrenergic #drugs # adrenergicdrugs
Adrenergic Drugs Part 1 | Pharmacology | Dr Najeeb👨⚕️
Like this video? Sign up now on our website at https://www.DrNajeebLectures.com
to access 1000+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $59 ONLY!
Sign up now on our website at https://members.drnajeeblectures.com/#!/register-fast
---------------------------------------------------------------------------------------------------------------------------
Why sign up for premium membership? Here's why!
Membership Features for premium website members.
1. More than 1000+ Medical Lectures.
2. Basic Medical Sciences & Clinical Medicine.
3. Mobile-friendly interface with android and iOS apps.
4. English subtitles and new videos every week.
5. Download option for offline video playback.
6. Fanatic customer support and that's 24/7.
7. Fast video playback option to learn faster.
8. Trusted by over 2M+ students in 190 countries.
---------------------------------------------------------------------------------------------------------------------------
▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
00:00:00 Introduction, Autonomic NS pharmacology, Subtypes
00:05:25 Neurophysiology of sympathetic and parasympathetic nervous system
00:10:30 How sympathetic nervous system activated? Function of hypothalamus and limbic system
00:16:20 Polyneuronal sympathetic descending pathway
00:19:16 Sympathetic outflow, Adrenergic and non-adrenergic receptors, acetylcholine, nor epinephrine
00:25:45 Recap
00:26:15 How nerve endings work? Neurotransmitter synthesis, storage and release
00:30:12 Synthesis of norepinephrine (Tyrosine, DOPA, Dopamine, Norepinephrine)
00:46:46 How norepinephrine release? Depolarization sensitive Calcium channel
00:55:15 Inhibitory function of Alpha 2 receptor
00:58:31 What happens to norepinephrine after its release?
01:07:16 Drugs effect on nerve endings of adrenergic transmission (Metyrosine, Reserpine, Guanethidine, Alpha methyl dopa)
01:29:50 Concept of agonist, antagonist, partial agonist, mixed agonist and antagonist
01:39:38 Adrenoceptor Blocker or antagonist (sympatholytic drugs)
Alpha blockers
Beta blockers
01:47:56 Recap
01:50:14 sympathomimetic Drugs and its classification
01:53:21 A) Direct acting sympathomimetic drugs
02:11:25 B) Indirect acting sympathomimetic drugs (cocaine, TCA)
02:22:40 Distribution of adrenergic receptors on different body tissues
02:43:23 Changes in body under the influence of adrenergic response
02:44:17 a) Changes in hairs
02:46:41 b) Changes in eyes (pupils, ciliary muscles, lens etc.)
03:01:12 c) Changes in GIT
---------------------------------------------------------------------------------------------------------------------------
Adrenergic Agonists are drugs that lead to stimulation of the adrenergic receptors. In doing so, adrenergic agonists generally simulate activation of certain aspects of the sympathetic nervous system and are thus also known as "sympathomimetics".
Mechanisms of Action
Overview
A diverse variety of sympathomimetics exist which operate using distinct mechanisms. In general, these compounds are divided into direct-acting, indirect-acting, or mixed-acting agonists depending on whether they directly activate adrenergic receptors or do so by indirect mechanisms
Direct-acting Agonists
Direct agonists physically bind the adrenergic receptor and simulate binding of an endogenous ligand. These compounds can be highly specific, activating only certain subtypes of receptors, or can be rather promiscuous.
Indirect-acting Agonists
Indirect agonists do not physically bind adrenergic receptors. Instead, these compounds indirectly lead to receptor activation through a variety of possible mechanisms which include promoting release of endogenously-stored norepinephrine from presynaptic terminals as well as inhibition of norepinephrine re-uptake and degradation from the synapse.
Mixed-acting Agonists
Mixed agonists simply refer to those compounds which display both direct and indirect mechanisms of actions. As such, these compounds directly bind adrenergic receptors but also promote the indirect mechanisms described above.
---------------------------------------------------------------------------------------------------------------------------
Join this channel to get access to perks:
Sign up now on our website at https://members.drnajeeblectures.com/#!/register-fast
https://www.youtube.com/channel/UCPHpx55tgrbm8FrYYCflAHw/join
Follow us on Facebook :- https://www.facebook.com/DrNajeeb/
Follow us on Instagram :- https://www.instagram.com/drnajeeblectures/
11:58
Sympathomimetics or Adrenergic Receptor Agonists pharmacology MADE EASY!
Sympathomimetics/ Adrenergic agonists are substances that mimic or modify the actions of e...
published: 26 Aug 2019
Sympathomimetics or Adrenergic Receptor Agonists pharmacology MADE EASY!
Sympathomimetics or Adrenergic Receptor Agonists pharmacology MADE EASY!
- Report rights infringement
- published: 26 Aug 2019
- views: 62346
Sympathomimetics/ Adrenergic agonists are substances that mimic or modify the actions of endogenous catecholamines of the sympathetic nervous system. Direct agonists directly activate adrenergic receptors while indirect agonists enhance the actions of endogenous catecholamines.
Sympathomimetic drug
Sympathomimetic drugs are stimulant compounds which mimic the effects of agonists of the sympathetic nervous system such as the catecholamines. (epinephrine (adrenaline), norepinephrine (noradrenaline), dopamine, etc.) Sympathomimetic drugs are used to treat cardiac arrest and low blood pressure, or even delay premature labor, among other things.
These drugs can act through several mechanisms, such as directly activating postsynaptic receptors, blocking breakdown and reuptake of certain neurotransmitters, or stimulating production and release of catecholamines.
Mechanisms of action
The mechanisms of sympathomimetic drugs can be direct-acting, such as α-adrenergic agonists, β-adrenergic agonists, and dopaminergic agonists; or indirect-acting, such as MAOIs, COMT inhibitors, release stimulants, and reuptake inhibitors that increase the levels of endogenous catecholamines.
Structure-activity relationship
For maximum sympathomimetic activity, a drug must have:
This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Sympathomimetic_drug
1.Sympathomimetic drugs Introduction - ANS Pharmac...
Sympathomimetics (Adrenergic Agonists)—Epinephrine...
Autonomic Pharmacology | Adrenergic Agonists...
Sympathomimetics Mechanism and Side Effects...
Pharmacology - ADRENERGIC RECEPTORS & AGONISTS (MA...
Adrenergic Drugs - Pharmacology, Animation...
Classification of Adrenergic Drugs || Individual A...
2.Sympathomimetic Drugs - Directly Acting sympatho...
Adrenergic Drugs Part 1 | Pharmacology | Dr Najeeb...
