Desvenlafaxine (brand name: Pristiq), also known as O-desmethylvenlafaxine, is an antidepressant of the serotonin-norepinephrine reuptake inhibitor class developed and marketed by Wyeth (now part of Pfizer). Desvenlafaxine is a synthetic form of the major active metabolite of venlafaxine (sold under the brand names Effexor and Efexor). It is being targeted as the first non-hormonal based treatment for menopause.

Wyeth announced on 23 January 2007 that it received an "approvable" letter from the Food and Drug Administration for desvenlafaxine. Final approval to sell the drug was contingent on a number of things, including:

The FDA approved the drug for antidepressant use in February 2008, and was to be available in US pharmacies in May 2008.

On February 4, 2009, Health Canada approved use of desvenlafaxine for treatment of depression in Canada. Pristiq is now available in Canadian pharmacies.

In the European Union desvenlafaxine succinate has not been approved for any indication. In 2008, Wyeth withdrew its application for Ellefore, the product under review for treatment of major depressive disorder. The reasons given by Wyeth, and comments regarding the findings of the reviewing agency are provided in a "question and answer" format document. The European Medicines Agency explained that

Ronnie Dean "Big Ron" Coleman (born May 13, 1964 in Bastrop, Louisiana) is an American professional bodybuilder who holds the record of eight straight wins as Mr. Olympia, a record career total that he shares with Lee Haney. Alongside his eight Mr. Olympia wins as a professional bodybuilder, Coleman holds the record for most wins as an IFBB professional with 26. He broke the previous record (held by Vince Taylor at 22 wins) in Moscow on November 5, 2004.

Ronnie Coleman graduated cum laude from Grambling State University (GSU) in 1986 with a B.S degree in accounting^{[citation needed]}. While attending Grambling State University Coleman also played football as a middle linebacker with the GSU Tigers under coach Eddie Robinson. After graduation, Coleman became a police officer in Arlington, Texas. Coleman's fellow officer Gustavo Arlotta suggested he attend the Metroflex gym, owned by amateur bodybuilder Brian Dobson. Dobson offered Coleman a free lifetime membership if he would allow him to train Coleman for the upcoming Mr. Texas bodybuilding competition that year.