Desipramine (also known as desmethylimipramine) is a tricyclic antidepressant (TCA). It inhibits the reuptake of norepinephrine and to a lesser extent serotonin. It is used to treat depression, but not considered a first line treatment since the introduction of SSRI antidepressants. Desipramine is an active metabolite of imipramine. It is sold under the brand names Norpramin and Pertofane.

Along with other tricyclics, desipramine has found use in treating neuropathic pain. The mechanism of action seems to involve the activation, through norepinephrine reuptake inhibition, of descending pathways in the spinal cord that block pain signals from ascending to the brain. Desipramine is one of the most potent and selective medications in this respect. It may also be used to treat symptoms of Attention Deficit Hyperactivity Disorder, as the underproduction of norepinephrine has been increasingly linked to symptoms associated with Attention Deficit Disorder^{[citation needed]}. It may also be used to treat symptoms of cocaine withdrawal.

Caylee Marie Anthony (August 9, 2005 – 2008) was an American two-year-old girl who was reported missing in Orlando, Florida, in July 2008, whose skeletal remains were found in a wooded area near her home in December 2008. Her then 22-year-old mother, Casey Marie Anthony, was tried for the first degree murder of Caylee but was acquitted. She was, however, convicted of misdemeanor counts of providing false information to police officers.

Caylee lived with her mother, Casey, and her maternal grandparents, George and Cindy Anthony. On July 15, 2008, Caylee was reported missing to 9-1-1 by Cindy, who said she had not seen Caylee for 31 days and that Casey's car smelled like a dead body had been inside of it. She said Casey had given varied explanations as to Caylee's whereabouts and finally admitted that day that she had not seen her daughter for weeks. Casey fabricated various stories, including telling detectives the child had been kidnapped by a fictitious nanny on June 9, and that she had been trying to find her, too frightened to alert the authorities. With the child still missing, Casey was charged with first degree murder in October and pled not guilty. On December 11, Caylee's skeletal remains were found with a blanket inside a trash bag in a wooded area near the family home. Investigative reports and trial testimony alternated between duct tape being found near the front of the skull and on the mouth of the skull. The medical examiner mentioned duct tape as one reason she ruled the death a homicide, but officially listed it as "death by undetermined means".

Russell Ira Crowe (born 7 April 1964) is a New Zealand born Australian actor, film producer and musician. He came to international attention for his role as Roman General Maximus Decimus Meridius in the 2000 historical epic film Gladiator, directed by Ridley Scott, for which he won an Academy Award for Best Actor, a Broadcast Film Critics Association Award for Best Actor, an Empire Award for Best Actor and a London Film Critics Circle Award for Best Actor and ten further nominations for Best Actor. Crowe appeared as the tobacco firm whistle blower Jeffrey Wigand in the 1999 film The Insider, for which he received five awards as Best Actor and seven nominations in the same category. In 2001, Crowe's portrayal of mathematician and Nobel Prize winner John F. Nash in the biopic A Beautiful Mind brought him numerous awards, including an BAFTA Award for Best Actor in a Leading Role, a Golden Globe Award for Best Actor category Motion Picture Drama and a Screen Actors Guild Award for Outstanding Performance by a Male Actor in a Leading Role.