S-14,671 is a naphthylpiperazine derivative which acts as a 5-HT_1A receptor agonist (pK_i = 9.3) with high efficacy and exceptional in vivo potency, and also as a 5-HT_2A and 5-HT_2C receptor antagonist (both are pK_i = 7.8). It displays only low and non-significant affinity for 5-HT_1B and 5-HT₃ sites.

In producing 5-HT_1A-mediated effects such as hypothermia and spontaneous tail flicks in rodents, S-14,671 is active at doses as low as 5 mcg s.c., and is about 10-fold more potent than 8-OH-DPAT and 100-fold more potent than flesinoxan and buspirone. Other 5-HT_1A-mediated effects of S-14,671 include induction of flat-body posture, corticosterone secretion, inhibition of morphine-induced antinociception, and attenuation of the electrical activity of the dorsal raphe nucleus.

S-14,671 has been found to possess powerful efficacy in the rodent forced swim test and in the pigeon conflict test, indicating marked antidepressant and anxiolytic effects, respectively, of which are also 5-HT_1A-mediated. It has never been trialed in humans, perhaps due to its potency being too great.^{[citation needed]}

S14 may refer to:

S₁₄ may refer to :

and also a shortening or designation for :

Justin Drew Bieber ( /ˈbiːbər/ BEE-bər, born March 1, 1994) is a Canadian Pop/R&B singer-songwriter, musician, and actor. Bieber was discovered in 2008 by Scooter Braun, who came across Bieber's videos on YouTube and later became his manager. Braun arranged for him to meet with Usher in Atlanta, Georgia, and Bieber was soon signed to Raymond Braun Media Group (RBMG), a joint venture between Braun and Usher, and then to a recording contract with Island Records offered by L.A. Reid. Bieber's debut single, "One Time", was released in 2009 and peaked in the top twenty in Canada and charted in the top thirty in several international markets. His debut album, the seven-track EP My World, followed in November 2009, and was soon certified platinum in the United States. He became the first artist to have seven songs from a debut album chart on the Billboard Hot 100.