The following are the baseball events of the year 1981 throughout the world.  

NOTE: Due to a strike in mid-season, the season was divided into a first half and a second half. The division winner of the first half (denoted East 1, West 1) played the division winner of the second half (denoted East 2, West 2).

Peter Edward Rose (born April 14, 1941), nicknamed "Charlie Hustle", is a former Major League Baseball player and manager. Rose played from 1963 to 1986, and managed from 1984 to 1989.

Rose, a switch hitter, is the all-time Major League leader in hits (4,256), games played (3,562), at-bats (14,053) and outs (10,328). He won three World Series rings, three batting titles, one Most Valuable Player Award, two Gold Gloves, the Rookie of the Year Award, and made 17 All-Star appearances at an unequaled five different positions (2B, LF, RF, 3B & 1B).

In August 1989, three years after he retired as an active player, Rose agreed to permanent ineligibility from baseball amidst accusations that he gambled on baseball games while playing for and managing the Reds, including claims that he bet on his own team. In 1991, the Baseball Hall of Fame formally voted to ban those on the "permanently ineligible" list from induction, after previously excluding such players by informal agreement among voters. In 2004, after years of public denial, Rose admitted to betting on baseball and on, but not against, the Reds. The issue of Rose's possible re-instatement, and election, to the Hall of Fame remains a contentious one throughout baseball.

Robert James "Rick" Monday, Jr. (born November 20, 1945 in Batesville, Arkansas) is a former center fielder in Major League Baseball and is currently a broadcast announcer. From 1966 through 1984, Monday, a center fielder for most of his career, played for the Kansas City/Oakland Athletics (1966–71), Chicago Cubs (1972–76) and Los Angeles Dodgers (1977–84). He batted and threw left-handed.

In a 19-season career, Monday compiled a .264 batting average with 241 home runs and 775 RBI. He was selected an All-Star in 1968 and 1978.

Monday began his baseball career starring at Santa Monica High School earning league honors.

Tommy Lasorda, then a scout for the Los Angeles Dodgers, offered Rick, and Rick's mother Nelda, $20,000 to sign with the Dodgers out of high school in 1963. But Arizona State University coach Bobby Winkles, who was also from Monday's native Arkansas, convinced them that he would look after Monday.

A star for the Sun Devils under head coach Winkles, on a team that included freshman Reggie Jackson, Monday led the Sun Devils to the 1965 College World Series championship (over Ohio State) and earned All-America and College Player of the Year honors. For the 1965 season he hit .359 with 34 extra-base hits.

Lynn Nolan Ryan, Jr. (born on January 31, 1947), nicknamed "The Ryan Express", is a former Major League Baseball pitcher. He is currently principal owner, president and CEO of the Texas Rangers.

During a major league record 27-year baseball career, he pitched in 1966 and from 1968 to 1993 for four different teams: the New York Mets, California Angels, Houston Astros, and Texas Rangers. He was inducted into the Baseball Hall of Fame in 1999.

Ryan, a hard-throwing right-handed pitcher, threw pitches that were regularly recorded above 100 miles per hour (160.93 km/h). The high velocity remained throughout his career, even into his 40s. Ryan was also known to throw a devastating 12–6 curveball at exceptional velocity for a breaking ball.

While his lifetime winning percentage was a relatively pedestrian .526, Ryan was an eight-time MLB All-Star, and his 5,714 career strikeouts rank first in baseball history by a significant margin. He leads the runner-up, Randy Johnson, by 839 strikeouts. Similarly, Ryan's 2,795 bases on balls lead second-place Steve Carlton by 962—walking over 50% more hitters than any other pitcher in Major League history. Other than Jackie Robinson (whose number was retired by the entire MLB), Ryan is currently the only major league baseball player to have his number retired by at least 3 different teams: the Angels, Astros, and Rangers.