AM251
AM-251 is an inverse agonist at the CB1 cannabinoid receptor. AM-251 is structurally very close to SR141716A (rimonabant); both are biarylpyrazole cannabinoid receptor antagonists. In AM-251 the p-chloro group attached to the phenyl substituent at C-5 of the pyrazole ring is replaced with a p-iodo group. The resulting compound exhibits slightly better binding affinity for the CB1 receptor (with a Ki value of 7.5nM) than SR141716A, which has a Ki value of 11.5nM, AM-251 is, however, about two-fold more selective for the CB1 receptor when compared to SR141716A. Like SR141716A, it is additionally a μ-opioid receptor antagonist.
See also
References
Podcasts:
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by Nana Mouskouri
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by The Fall
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by Hotlegs
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by Sonu Nigam
Oh Mama Mama
by: Nana MouskouriOh mamma mamma
I am very happy
I never knew
A girl happier than me
The bells are peeling
And my head is reeling
I have got a feeling
This just cannot be
La la la la.....
La la la la.....
I hear the music
Floating through the window
And I see them dancing
In the city square
My heart is beating
And keeps on repeating
I will soon be meeting
My lover who is there
Refrain
Oh mamma mamma
Mamma wish me well now
Help me weave a spell now
Make my lover care
Eyes as bright as jewels
In the moonlight
He's the one,the only one
And I love him so
Oh!please mamma
Tell me I look pretty
I must be on my way
I can't wait to go
Oh soon my love
And I will be together
Into a new world
We will dance away
Oh!mamma maybe
He's going to tell me
Darling,we will marry
What a happy day