The Shrine of Husayn ibn ‘Alī (Arabic: مقام الامام الحسين‎) is one of the oldest mosques in the world and a holy site of Shīah Islām in the city of Karbalā, Iraq. It stands on the site of the grave of Husayn ibn ‘Alī, the second grandson of Muhammad, near the place where he was killed during the Battle of Karbalā in 680 C.E.. The tomb of Husayn ibn ‘Alī is one of the holiest places for Shī‘as outside of Mecca and Medina, and many make pilgrimages to the site. Every year, millions of pilgrims visit the city to observe ‘Āshūrā, which marks the anniversary of Husayn ibn ‘Alī's death.

The Umayyad and Abbasid caliphs prevented construction of the shrines and discouraged pilgrimage to the sites. The tomb and its annexes were destroyed by Abbasid caliph Al-Mutawakkil in 850-851 and Shi'a pilgrimage was prohibited, but shrines in Karbala and Najaf were built by the Buwayhid emir 'Adud al-Daula in 979-80.

Two main roads lead the visitor to Karbala. One is from the Iraqi capital Baghdad, through Al-Musails, and the other is from Najaf. At the city's entrance there is a row of houses decorated with wooden columns.

Hussein ibn ‘Alī ibn Abī Ṭālib (Arabic: حسين بن علي بن أبي طالب‎)‎ (3rd Sha'aban 4 AH – 10th Muharram 61 AH; 8 January 626 CE – 10 October 680 CE, also spelled Hussayn) was the son of ‘Alī ibn Abī Ṭālib (final Rashidun Caliph and first Shia Imam) and Fātimah Zahrā (daughter of the Islamic prophet Muhammad) and the younger brother of Hasan ibn Ali. Husayn is an important figure in Islam as he is a member of the Ahl al-Bayt (the household of Muhammad) and Ahl al-Kisa, as well as being a Shia Imam, and one of The Fourteen Infallibles of Shia Twelvers.

Husayn ibn ‘Alī is exalted by all the Shia as a martyr who fought tyranny as he refused to pledge allegiance to Yazid I, the Umayyad caliph. He rose up to create a regime that would reinstate a "true" Islamic polity as opposed to what he considered the unjust rule of the Umayyads. As a consequence, Husayn was killed and beheaded in the Battle of Karbala in 680 (61AH) by Shimr Ibn Thil-Jawshan. The annual funeral in the memory of him, his family, his children and his As'haab (companions) is called Ashura (tenth day of Muharram) and is a day of mourning for Shia Muslims.