X-ray computed tomography, also Computed tomography (CT scan) or Computed axial tomography (CAT scan), can be used for medical imaging and industrial imaging methods employing tomography created by computer processing.[1] Digital geometry processing is used to generate a three-dimensional image of the inside of an object from a large series of two-dimensional X-ray images taken around a single axis of rotation.[2]
CT produces a volume of data that can be manipulated, through a process known as "windowing", in order to demonstrate various bodily structures based on their ability to block the X-ray beam. Although historically the images generated were in the axial or transverse plane, perpendicular to the long axis of the body, modern scanners allow this volume of data to be reformatted in various planes or even as volumetric (3D) representations of structures. Although most common in medicine, CT is also used in other fields, such as nondestructive materials testing. Another example is archaeological uses such as imaging the contents of sarcophagi.
Usage of CT has increased dramatically over the last two decades in many countries.[3] An estimated 72 million scans were performed in the United States in 2007.[4] It is estimated that 0.4% of current cancers in the United States are due to CTs performed in the past and that this may increase to as high as 1.5-2% with 2007 rates of CT usage;[5] however, this estimate is disputed.[6]
The word "tomography" is derived from the Greek tomos (slice) and graphein (to write). Computed tomography was originally known as the "EMI scan" as it was developed at a research branch of EMI, a company best known today for its music and recording business. It was later known as computed axial tomography (CAT or CT scan) and body section röntgenography.
Although the term "computed tomography" could be used to describe positron emission tomography and single photon emission computed tomography, in practice it usually refers to the computation of tomography from X-ray images, especially in older medical literature and smaller medical facilities.
In MeSH, "computed axial tomography" was used from 1977–79, but the current indexing explicitly includes "X-ray" in the title.[7]
Spinning tube, commonly called spiral CT, or helical CT in which an entire X-ray tube is spun around the central axis of the area being scanned. These are the dominant type of scanners on the market because they have been manufactured longer and offer lower cost of production and purchase. The main limitation of this type is the bulk and inertia of the equipment (X-ray tube assembly and detector array on the opposite side of the circle) which limits the speed at which the equipment can spin.
Electron beam tomography is a specific form of CT in which a large enough X-ray tube is constructed so that only the path of the electrons, traveling between the cathode and anode of the X-ray tube, are spun using deflection coils. This type has a major advantage since sweep speeds can be much faster, allowing for less blurry imaging of moving structures, such as the heart and arteries. However, far fewer CTs of this design have been produced, mainly due to the higher cost associated with building a much larger X-ray tube and detector array.
Typical CT Scout view as used for planning an exam
Since its introduction in the 1970s, CT has become an important tool in medical imaging to supplement X-rays and medical ultrasonography. It has more recently been used for preventive medicine or screening for disease, for example CT colonography for patients with a high risk of colon cancer, or full-motion heart scans for patients with high risk of heart disease. A number of institutions offer full-body scans for the general population.
CT scanning of the head is typically used to detect infarction, tumours, calcifications, haemorrhage and bone trauma. Of the above, hypodense (dark) structures indicate infarction or tumours, hyperdense (bright) structures indicate calcifications and haemorrhage and bone trauma can be seen as disjunction in bone windows. Ambulances equipped with small bore multi-sliced CT scanners respond to cases involving stroke or head trauma.
CT can be used for detecting both acute and chronic changes in the lung parenchyma, that is, the internals of the lungs. It is particularly relevant here because normal two-dimensional X-rays do not show such defects. A variety of techniques are used, depending on the suspected abnormality. For evaluation of chronic interstitial processes (emphysema, fibrosis, and so forth), thin sections with high spatial frequency reconstructions are used; often scans are performed both in inspiration and expiration. This special technique is called high resolution CT. Therefore, it produces a sampling of the lung and not continuous images.
CT pulmonary angiogram (CTPA) is a medical diagnostic test used to diagnose pulmonary embolism (PE). It employs computed tomography and an iodine based contrast agent to obtain an image of the pulmonary arteries.
With the advent of subsecond rotation combined with multi-slice CT (up to 320-slices), high resolution and high speed can be obtained at the same time, allowing excellent imaging of the coronary arteries (cardiac CT angiography).
CT is a sensitive method for diagnosis of abdominal diseases. It is used frequently to determine stage of cancer and to follow progress. It is also a useful test to investigate acute abdominal pain.
CT is often used to image complex fractures, especially ones around joints, because of its ability to reconstruct the area of interest in multiple planes. Fractures, ligamentous injuries and dislocations can easily be recognised with a 0.2 mm resolution.[8][9]
There are several advantages that CT has over traditional 2D medical radiography. First, CT completely eliminates the superimposition of images of structures outside the area of interest. Second, because of the inherent high-contrast resolution of CT, differences between tissues that differ in physical density by less than 1% can be distinguished. Finally, data from a single CT imaging procedure consisting of either multiple contiguous or one helical scan can be viewed as images in the axial, coronal, or sagittal planes, depending on the diagnostic task. This is referred to as multiplanar reformatted imaging.
CT is regarded as a moderate- to high-radiation diagnostic technique. The improved resolution of CT has permitted the development of new investigations, which may have advantages; compared to conventional radiography, for example, CT angiography avoids the invasive insertion of a catheter. CT Colonography (also known as Virtual Colonoscopy or VC for short) may be as useful as a barium enema for detection of tumors, but may use a lower radiation dose. CT VC is increasingly being used in the UK as a diagnostic test for bowel cancer and can negate the need for a colonoscopy.
The radiation dose for a particular study depends on multiple factors: volume scanned, patient build, number and type of scan sequences, and desired resolution and image quality. In addition, two helical CT scanning parameters that can be adjusted easily and that have a profound effect on radiation dose are tube current and pitch. Computed tomography (CT) scan has been shown to be more accurate than radiographs in evaluating anterior interbody fusion but may still over-read the extent of fusion.[10]
CT scans use a high level of ionizing radiation. Ionizing radiation has the capacity to break molecular bonds, and thus alter the molecular structure of the irradiated molecules. In the human body, a cell's operation is controlled by the chemical structure of the DNA molecule included in the cell. Experiments showed that ionizing radiation cause DNA double strand breaks at a rate of 35 double strand breaks per cell per Gray,[11] and removes a portion of the epigenetic markers of the DNA,[12] which regulate the gene expression. At the radiation doses, which typical CT scans impose, a DNA molecule of 40%-100% of the irradiated cells is damaged by one or more double strand breaks. This insult is followed by an effort of the cell in attempt to repair the damaged and broken DNA, however, the repair process is not perfect,[13] and faults that are not properly repaired can cause the cell to stray from its original design of operation. The improper operation can manifest in cell death, cancer, and in other puzzling health conditions, as can be expected from an operation, which randomly alter cell's DNA, and epigenetic markers.[14] A portion of the population possess a flawed DNA repair mechanism, and thus suffer a greater insult due to exposure to radiation.[11] Unlike CT, MRI does not use ionizing radiation, and does not cause double strand breaks to the DNA.[15]
The FDA and CRCPD have recommended to use less than 500 mGy in brain perfusion CT scans, a scan which is commonly performed in the investigation of suspected stroke, and a dose that is sufficient to induce 17 double strand breaks in each cell of the brain. The recommendation was made in response to multiple complaints from patients over a loss of a band of their head's hair, which was traced to be due to CT scans of higher doses, that were performed over them.[16]
Studies showed that radiation of ionizing radiation caused cognitive problems. Radiation of 60-310 mGy at the 8 to 15 weeks of gestation, or of 280-870 mGy at the 16 to 25 weeks of gestation caused mental retardation.[17] Radiation of 100 mGy to the head at infancy caused cognitive deficits.[18] Radiation of 1300-1500mGy to the head at childhood caused schizophrenia, and lowered IQ scores.[17] Exposure of adults to 150−500 mSv caused cerebrovascular pathology, and exposure to 300 mSv caused neuropsychiatric, neurophysiological, neuroimmune, neuropsychological, and neuroimaging dose related effects.[17]
The increased use of CT scans has been the greatest in two fields: screening of adults (screening CT of the lung in smokers, virtual colonoscopy, CT cardiac screening, and whole-body CT in asymptomatic patients) and CT imaging of children. Shortening of the scanning time to around 1 second, eliminating the strict need for the subject to remain still or be sedated, is one of the main reasons for the large increase in the pediatric population (especially for the diagnosis of appendicitis).[19] CT scans of children have been estimated to produce non-negligible increases in the probability of lifetime cancer mortality, leading to calls for the use of reduced current settings for CT scans of children.[20]
These calculations are based on similar radiation exposures experienced by those present during the atomic bomb explosions in Japan during the second world war and nuclear industry works.[19] Estimated lifetime cancer mortality risks attributable to the radiation exposure from a CT in a 1-year-old are 0.18% (abdominal) and 0.07% (head) — an order of magnitude higher than for adults — although those figures still represent a small increase in cancer mortality over the background rate. In the United States, of approximately 600,000 abdominal and head CT examinations annually performed in children under the age of 15 years, a rough estimate is that 500 of these individuals might ultimately die from cancer attributable to the CT radiation.[21] The additional risk is still low: 0.35% compared to the background risk of dying from cancer of 23%.[21] However, if these statistics are extrapolated to the current number of CT scans, the additional rise in cancer mortality could be 1.5 to 2%. Furthermore, certain conditions can require children to be exposed to multiple CT scans.[19]
In 2009, a number of studies that further defined the risk of cancer that may be caused by CT scans appeared.[22] One study indicated that radiation by CT scans is often higher and more variable than cited, and each of the 19,500 CT scans that are daily performed in the US is equivalent to 30 to 442 chest X-rays in radiation. It has been estimated that CT radiation exposure will result in 29,000 new cancer cases just from the CT scans performed in 2007.[22] The most common cancers caused by CT are thought to be lung cancer, colon cancer and leukemia, with younger people and women more at risk. These conclusions, however, are criticized by the American College of Radiology (ACR), which maintains that the life expectancy of CT scanned patients is not that of the general population and that the model of calculating cancer is based on total-body radiation exposure and thus faulty.[22]
CT scans can be performed with different settings for lower exposure in children, although these techniques are often not employed. Surveys have suggested that, at the current time, many CT scans are performed unnecessarily. Ultrasound scanning or magnetic resonance imaging are alternatives (for example, in appendicitis or brain imaging) without the risk of radiation exposure. Although CT scans come with an additional risk of cancer (it can be estimated that the radiation exposure from a full body scan is the same as standing 2.4 km away from the World War II atomic bomb blasts in Japan[23][24]), especially in children, the benefits that stem from their use outweigh the risk in many cases.[21] Studies support informing parents of the risks of pediatric CT scanning.[25]
The following table include data of typical scan doses, as were observed in a survey of a few CT machines. The data represent an average of the observed values, however the maximal observed values in the survey were about two times higher than the average values. The table include data for a few specific scanning protocols, however other scanning protocols of the same body parts exist, and some of which subject patients to greater radiation.[26] In some studies, the same body part is scanned twice, once without contrast agent, and once with contrast agent, which doubles the stated scan dose.
For purposes of comparison, the average background exposure in the UK is 1-3 mSv per year.
The radiation dose reported in the Gray or mGy unit is proportional to the amount energy that the irradiated body part is expected to absorb, and the physical effect (such as double strand breaks) on the cell's chemical bonds by x-ray radiation is proportional to that energy.
The volume weighted CT dose index (CTDIvol) is used to report an absorbed dose in the Gray unit, that is proportional to the average of the energy that is absorbed by the body part, since the amount of energy that is absorbed is greater at the skin, and lower at the center of the body part.
The Sievert unit is used in the report of the effective dose. The Sievert unit in the context of CT scans, do not correspond to the actual radiation, that the scanned body part absorb, but rather to an other radiation level of an other scenario, in which the whole body is subjected to the other radiation level, and where the other radiation level is of a magnitude, that is estimated to have the same probability to induce cancer, as the CT scan.[30] Thus, as is shown in the table above, the actual radiation that is absorbed by a scanned body part is often much larger than the effective dose disclose.
Note, that even though the stated objective of the effective dose is to report a whole body radiation value, that is proportional to the biological effect of the actual radiation, the effective dose measure the biological effect based on statistical studies of cancer rates in a population, that was exposed to radiation from a nuclear blast, and thus its fulfillment of its objective is questionable, due to the possibility that the biological effect of radiation from a nuclear blast is different, due to the fact that exposure to a nuclear blast during war is a psychologically traumatic event in itself, due to covering only one biological effect, namely cancer, and due to a very limited theoretical understanding.
The dose length product (DLP) is the multiplication of the CTDIvol with the length of the portion of the body part that was scanned, and has the units of Gray*Centimeter. It is used, by multiplication with constants, to derive the effective dose, and cancer risk, that correspond to the irradiation of a portion of a body part, and can be used in other calculations, which include the multiplication, that the CTDIvol include.
Because contrast CT scans rely on intravenously administered contrast agents in order to provide superior image quality, there is a low but non-negligible level of risk associated with the contrast agents themselves. Many patients report nausea and discomfort, including warmth in the crotch, which mimics the sensation of wetting oneself. Certain patients may experience severe and potentially life-threatening allergic reactions to the contrast dye, and some patients die due to that allergic reaction.
The contrast agent may also induce kidney damage. The risk of this is increased with patients who have preexisting renal insufficiency, preexisting diabetes, or reduced intravascular volume. In general, if a patient has normal kidney function, then the risks of contrast nephropathy are negligible. Patients with mild kidney impairment are usually advised to ensure full hydration for several hours before and after the injection. For moderate kidney failure, the use of iodinated contrast should be avoided; this may mean using an alternative technique instead of CT, e.g., MRI. However, patients with severe renal failure requiring dialysis do not require special precautions, as their kidneys have so little function remaining that any further damage would not be noticeable and the dialysis will remove the contrast agent.
An important issue within radiology today is how to reduce the radiation dose during CT examinations without compromising the image quality. In general, higher radiation doses result in higher-resolution images, while lower doses lead to increased image noise and unsharp images. Increased dosage raises the risk of radiation induced cancer — a four-phase abdominal CT gives the same radiation dose as 300 chest x-rays. Several methods that can reduce the exposure to ionizing radiation during a CT scan exist.
- New software technology can significantly reduce the required radiation dose.
- Individualize the examination and adjust the radiation dose to the body type and body organ examined. Different body types and organs require different amounts of radiation.
- Prior to every CT examination, evaluate the appropriateness of the exam whether it is motivated or if another type of examination is more suitable. Higher resolution is not always suitable for any given scenario, such as detection of small pulmonary masses[31]
Although CT is a relatively accurate test, it is liable to produce artifacts, such as the following:[2], Chapters 3 and 5
- Streak artifact
- Streaks are often seen around materials that block most X-rays, such as metal or bone. These streaks can be caused by undersampling, photon starvation, motion, beam hardening, or scatter. This type of artifact commonly occurs in the posterior fossa of the brain, or if there are metal implants. The streaks can be reduced using newer reconstruction techniques.[32]
- Partial volume effect
- This appears as "blurring" over sharp edges. It is due to the scanner being unable to differentiate between a small amount of high-density material (e.g., bone) and a larger amount of lower density (e.g., cartilage). The processor tries to average out the two densities or structures, and information is lost. This can be partially overcome by scanning using thinner slices.
- Ring artifact
- Probably the most common mechanical artifact, the image of one or many "rings" appears within an image. This is usually due to a detector fault.
- Noise artifact
- This appears as graining on the image and is caused by a low signal to noise ratio. This occurs more commonly when a thin slice thickness is used. It can also occur when the power supplied to the X-ray tube is insufficient to penetrate the anatomy.
- Motion artifact
- This is seen as blurring and/or streaking, which is caused by movement of the object being imaged. Motion blurring might be reduced using a new technique called IFT (incompressible flow tomography).[33]
- Windmill
- Streaking appearances can occur when the detectors intersect the reconstruction plane. This can be reduced with filters or a reduction in pitch.
- Beam hardening
- This can give a "cupped appearance". It occurs when there is more attenuation in the center of the object than around the edge. This is easily corrected by filtration and software.
Usage of CT has increased dramatically over the last two decades.[3] An estimated 72 million scans were performed in the United States in 2007.[4] In Calgary, Canada 12.1% of people who present to the emergency with an urgent complaint received a CT scan, most commonly either of the head or of the abdomen. The percentage who received CT, however, varied markedly by the emergency physician who saw them from 1.8% to 25%.[34] In the emergency department in the United States, CT or MRI imaging is done in 15% of people who present with injuries as of 2007 (up from 6% in 1998).[35]
3D reconstruction of the brain and eyeballs from CT scanned DICOM images. In this image, areas with the density of bone or air were made transparent, and the slices stacked up in an approximate free-space alignment. The outer ring of material around the brain are the soft tissues of skin and muscle on the outside of the skull. A black box encloses the slices to provide the black background. Since these are simply 2D images stacked up, when viewed on edge the slices disappear since they have effectively zero thickness. Each DICOM scan represents about 5mm of material averaged into a thin slice.
X-ray slice data is generated using an X-ray source that rotates around the object; X-ray sensors are positioned on the opposite side of the circle from the X-ray source. The earliest sensors were scintillation detectors, with photomultiplier tubes excited by (typically) cesium iodide crystals. Cesium iodide was replaced during the 1980s by ion chambers containing high-pressure Xenon gas. These systems were in turn replaced by scintillation systems based on photodiodes instead of photomultipliers and modern scintillation materials with more desirable characteristics. Many data scans are progressively taken as the object is gradually passed through the gantry.
Newer machines with faster computer systems and newer software strategies can process not only individual cross sections but continuously changing cross sections as the gantry, with the object to be imaged slowly and smoothly slid through the X-ray circle. These are called helical or spiral CT machines. Their computer systems integrate the data of the moving individual slices to generate three dimensional volumetric information (3D-CT scan), in turn viewable from multiple different perspectives on attached CT workstation monitors. This type of data acquisition requires enormous processing power, as the data are arriving in a continuous stream and must be processed in real-time.
In conventional CT machines, an X-ray tube and detector are physically rotated behind a circular shroud (see the image above right); in the electron beam tomography (EBT), the tube is far larger and higher power to support the high temporal resolution. The electron beam is deflected in a hollow funnel-shaped vacuum chamber. X-rays are generated when the beam hits the stationary target. The detector is also stationary. This arrangement can result in very fast scans, but is extremely expensive.
CT scanner with cover removed to show the principle of operation
CT is used in medicine as a diagnostic tool and as a guide for interventional procedures. Sometimes contrast materials such as intravenous iodinated contrast are used. This is useful to highlight structures such as blood vessels that otherwise would be difficult to delineate from their surroundings. Using contrast material can also help to obtain functional information about tissues.
Once the scan data has been acquired, the data must be processed using a form of tomographic reconstruction, which produces a series of cross-sectional images. The most common technique in general use is filtered back projection, which is straightforward to implement and can be computed rapidly. In terms of mathematics, this method is based on the Radon transform. However, this is not the only technique available: the original EMI scanner solved the tomographic reconstruction problem by linear algebra, but this approach was limited by its high computational complexity, especially given the computer technology available at the time. More recently, manufacturers have developed iterative physical model-based expectation-maximization techniques. These techniques are advantageous because they use an internal model of the scanner's physical properties and of the physical laws of X-ray interactions. By contrast, earlier methods have assumed a perfect scanner and highly simplified physics, which leads to a number of artifacts and reduced resolution - the result is images with improved resolution, reduced noise and fewer artifacts, as well as the ability to greatly reduce the radiation dose in certain circumstances. The disadvantage is a very high computational requirement, which is at the limits of practicality for current scan protocols.
Pixels in an image obtained by CT scanning are displayed in terms of relative radiodensity. The pixel itself is displayed according to the mean attenuation of the tissue(s) that it corresponds to on a scale from +3071 (most attenuating) to -1024 (least attenuating) on the Hounsfield scale. Pixel is a two dimensional unit based on the matrix size and the field of view. When the CT slice thickness is also factored in, the unit is known as a Voxel, which is a three-dimensional unit. The phenomenon that one part of the detector cannot differentiate between different tissues is called the "Partial Volume Effect". That means that a big amount of cartilage and a thin layer of compact bone can cause the same attenuation in a voxel as hyperdense cartilage alone. Water has an attenuation of 0 Hounsfield units (HU), while air is -1000 HU, cancellous bone is typically +400 HU, cranial bone can reach 2000 HU or more (os temporale) and can cause artifacts. The attenuation of metallic implants depends on atomic number of the element used: Titanium usually has an amount of +1000 HU, iron steel can completely extinguish the X-ray and is, therefore, responsible for well-known line-artifacts in computed tomograms. Artifacts are caused by abrupt transitions between low- and high-density materials, which results in data values that exceed the dynamic range of the processing electronics.
Contrast mediums used for X-ray CT, as well as for plain film X-ray, are called radiocontrasts. Radiocontrasts for X-ray CT are, in general, iodine-based.[36] Often, images are taken both with and without radiocontrast. CT images are called precontrast or native-phase images before any radiocontrast has been administrated, and postcontrast after radiocontrast administration.[37]
Because contemporary CT scanners offer isotropic or near isotropic, resolution, display of images does not need to be restricted to the conventional axial images. Instead, it is possible for a software program to build a volume by "stacking" the individual slices one on top of the other. The program may then display the volume in an alternative manner.[38]
Typical screen layout for diagnostic software, showing one 3D and three MPR views
Multiplanar reconstruction (MPR) is the simplest method of reconstruction. A volume is built by stacking the axial slices. The software then cuts slices through the volume in a different plane (usually orthogonal). As an option, a special projection method, such as maximum-intensity projection (MIP) or minimum-intensity projection (mIP), can be used to build the reconstructed slices.
MPR is frequently used for examining the spine. Axial images through the spine will only show one vertebral body at a time and cannot reliably show the intervertebral discs. By reformatting the volume, it becomes much easier to visualise the position of one vertebral body in relation to the others.
Modern software allows reconstruction in non-orthogonal (oblique) planes so that the optimal plane can be chosen to display an anatomical structure. This may be particularly useful for visualising the structure of the bronchi as these do not lie orthogonal to the direction of the scan.
For vascular imaging, curved-plane reconstruction can be performed. This allows bends in a vessel to be "straightened" so that the entire length can be visualised on one image, or a short series of images. Once a vessel has been "straightened" in this way, quantitative measurements of length and cross sectional area can be made, so that surgery or interventional treatment can be planned.
MIP reconstructions enhance areas of high radiodensity, and so are useful for angiographic studies. MIP reconstructions tend to enhance air spaces so are useful for assessing lung structure.
A threshold value of radiodensity is set by the operator (e.g., a level that corresponds to bone). From this, a three-dimensional model can be constructed using edge detection image processing algorithms and displayed on screen. Multiple models can be constructed from various thresholds, allowing different colors to represent each anatomical component such as bone, muscle, and cartilage. However, the interior structure of each element is not visible in this mode of operation.
Surface rendering is limited in that it will display only surfaces that meet a threshold density, and will display only the surface that is closest to the imaginary viewer. In volume rendering, transparency and colors are used to allow a better representation of the volume to be shown in a single image. For example, the bones of the pelvis could be displayed as semi-transparent, so that, even at an oblique angle, one part of the image does not conceal another.
Where different structures have similar radiodensity, it can become impossible to separate them simply by adjusting volume rendering parameters. The solution is called segmentation, a manual or automatic procedure that can remove the unwanted structures from the image.
Industrial CT Scanning (industrial computed tomography) is a process which utilizes x-ray equipment to produce 3D representations of components both externally and internally. Industrial CT scanning has been utilized in many areas of industry for internal inspection of components. Some of the key uses for CT scanning have been flaw detection, failure analysis, metrology, assembly analysis and reverse engineering applications
In the early 1900s, the Italian radiologist Alessandro Vallebona proposed a method to represent a single slice of the body on the radiographic film. This method was known as tomography. The idea is based on simple principles of projective geometry: moving synchronously and in opposite directions the X-ray tube and the film, which are connected together by a rod whose pivot point is the focus; the image created by the points on the focal plane appears sharper, while the images of the other points annihilate as noise. This is only marginally effective, as blurring occurs in only the "x" plane. There are also more complex devices that can move in more than one plane and perform more effective blurring.
The mathematical theory behind the Tomographic reconstruction dates back to 1917 where the invention of Radon Transform[39][40] by an Austrian mathematician Johann Radon. He showed mathematically that a function could be reconstructed from an infinite set of its projections.[41] In 1937, a Polish mathematician, named Stefan Kaczmarz, developed a method to find an approximate solution to a large system of linear algebraic equations.[42][43] This led the foundation to another powerful reconstruction method called "Algebraic Reconstruction Technique (ART)" which was later adapted by Sir Godfrey Hounsfield as the image reconstruction mechanism in his famous invention, the first commercial CT scanner. In 1956, Ronald N. Bracewell used a method similar to Radon Transform to reconstruct a map of solar radiation from a set of solar radiation measurements.[44] In 1959, William Oldendorf, a UCLA neurologist and senior medical investigator at the West Los Angeles Veterans Administration hospital, conceived an idea for "scanning a head through a transmitted beam of X-rays, and being able to reconstruct the radiodensity patterns of a plane through the head" after watching an automated apparatus built to reject frost-bitten fruit by detecting dehydrated portions. In 1961, he built a prototype in which an X-ray source and a mechanically coupled detector rotated around the object to be imaged. By reconstructing the image, this instrument could get an X-ray picture of a nail surrounded by a circle of other nails, which made it impossible to X-ray from any single angle.[45] In his landmark paper, published in 1961, he described the basic concept later used by Allan McLeod Cormack to develop the mathematics behind computerized tomography. In October, 1963 Oldendorf received a U.S. patent for a "radiant energy apparatus for investigating selected areas of interior objects obscured by dense material," Oldendorf shared the 1975 Lasker award with Hounsfield for that discovery.[46]
Tomography has been one of the pillars of radiologic diagnostics until the late 1970s, when the availability of minicomputers and of the transverse axial scanning method – this last due to the work of Godfrey Hounsfield and South African-born Allan McLeod Cormack – gradually supplanted it as the modality of CT. In terms of mathematics, the method is based upon the use of the Radon Transform. But as Cormack remembered later,[47] he had to find the solution himself since it was only in 1972 that he learned of the work of Radon, by chance.
The first commercially viable CT scanner was invented by Sir Godfrey Hounsfield in Hayes, United Kingdom, at EMI Central Research Laboratories using X-rays. Hounsfield conceived his idea in 1967.[48] The first EMI-Scanner was installed in Atkinson Morley Hospital in Wimbledon, England, and the first patient brain-scan was done on 1 October 1971.[49] It was publicly announced in 1972.
The original 1971 prototype took 160 parallel readings through 180 angles, each 1° apart, with each scan taking a little over 5 minutes. The images from these scans took 2.5 hours to be processed by algebraic reconstruction techniques on a large computer. The scanner had a single photomultiplier detector, and operated on the Translate/Rotate principle.[49]
It has been claimed that thanks to the success of The Beatles, EMI could fund research and build early models for medical use.[50] The first production X-ray CT machine (in fact called the "EMI-Scanner") was limited to making tomographic sections of the brain, but acquired the image data in about 4 minutes (scanning two adjacent slices), and the computation time (using a Data General Nova minicomputer) was about 7 minutes per picture. This scanner required the use of a water-filled Perspex tank with a pre-shaped rubber "head-cap" at the front, which enclosed the patient's head. The water-tank was used to reduce the dynamic range of the radiation reaching the detectors (between scanning outside the head compared with scanning through the bone of the skull). The images were relatively low resolution, being composed of a matrix of only 80 x 80 pixels.
In the U.S., the first installation was at the Mayo Clinic. As a tribute to the impact of this system on medical imaging the Mayo Clinic has an EMI scanner on display in the Radiology Department. Allan McLeod Cormack of Tufts University in Massachusetts independently invented a similar process, and both Hounsfield and Cormack shared the 1979 Nobel Prize in Medicine.[51][52]
The first CT system that could make images of any part of the body and did not require the "water tank" was the ACTA (Automatic Computerized Transverse Axial) scanner designed by Robert S. Ledley, DDS, at Georgetown University. This machine had 30 photomultiplier tubes as detectors and completed a scan in only 9 translate/rotate cycles, much faster than the EMI-scanner. It used a DEC PDP11/34 minicomputer both to operate the servo-mechanisms and to acquire and process the images. The Pfizer drug company acquired the prototype from the university, along with rights to manufacture it. Pfizer then began making copies of the prototype, calling it the "200FS" (FS meaning Fast Scan), which were selling as fast as they could make them. This unit produced images in a 256×256 matrix, with much better definition than the EMI-Scanner's 80×80.
Since the first CT scanner, CT technology has vastly improved. Improvements in speed, slice count, and image quality have been the major focus primarily for cardiac imaging. Scanners now produce images much faster and with higher resolution enabling doctors to diagnose patients more accurately and perform medical procedures with greater precision. In the late 90's CT scanners broke into two major groups, "Fixed CT" and "Portable CT". "Fixed CT Scanners" are large, require a dedicated power supply, electrical closet, HVAC cooling system, a separate workstation room, and a large lead lined room. "Fixed CT Scanners" can also be mounted inside large tractor trailers and driven from site to site and are known as "Mobile CT Scanners". "Portable CT Scanners" are light weight, small, and mounted on wheels. These scanners often have built-in lead shielding and run off of batteries or standard wall power.
Pneumoencephalography Study for brain was quickly replaced by CT. A form of tomography can be performed by moving the X-ray source and detector during an exposure. Anatomy at the target level remains sharp, while structures at different levels are blurred. By varying the extent and path of motion, a variety of effects can be obtained, with variable depth of field and different degrees of blurring of "out of plane" structures.[53]:25 Although largely obsolete, conventional tomography is still used in specific situations such as dental imaging (orthopantomography) or in intravenous urography.
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