Southern Cone (Spanish: Cono Sur, Portuguese: Cone Sul) is a geographic region composed of the southernmost areas of South America, south of the Tropic of Capricorn. Although geographically this includes part of Southern and Southeast (São Paulo) of Brazil, in terms of political geography the Southern cone has traditionally comprised Argentina, Chile, Paraguay, and Uruguay. In the narrowest sense, it only covers Argentina, Chile and Uruguay, bounded on the north by the states of Brazil, Paraguay, Bolivia and Peru, on the west by the Pacific Ocean, and south to the junction between the Pacific and Atlantic Oceans, which it is the closest continental area of Antarctica (1000 km).

The main language spoken in the region is Spanish owing to the Spanish colonization from the 16th to the 19th century; Brazilians speak Portuguese.

High life expectancy, the highest Human Development Index of Latin America, high standard of living, significant participation in the global markets and the emerging economy of its members make the Southern Cone the most prosperous macro-region in South America.