Life (cf. biota) is a characteristic that distinguishes objects that have signaling and self-sustaining processes from those that do not,[1][2] either because such functions have ceased (death), or else because they lack such functions and are classified as inanimate.[3][4] Biology is the science concerned with the study of life.
Any contiguous living system is called an organism. These animate entities undergo metabolism, maintain homeostasis, possess a capacity to grow, respond to stimuli, reproduce and, through natural selection, adapt to their environment in successive generations. More complex living organisms can communicate through various means.[1][5] A diverse array of living organisms can be found in the biosphere of Earth, and the properties common to these organisms—plants, animals, fungi, protists, archaea, and bacteria—are a carbon- and water-based cellular form with complex organization and heritable genetic information.
Scientific evidence suggests that life began on Earth some 3.7 billion years ago. The mechanism by which life emerged is still being investigated. Since then, life has evolved into a wide variety of forms, which biologists have classified into a hierarchy of Taxa. Life can survive and thrive in a wide range of conditions. In philosophy and religion, the conception of life and its nature varies. Both offer interpretations as to how life relates to existence and consciousness, and both touch on many related issues, including life stance, purpose, conception of a god or gods, a soul or an afterlife.
Herds of zebra and impala gathering on the
Maasai Mara plain
Some of the earliest theories of life were materialist, holding that all that exists is matter, and that all life is merely a complex form or arrangement of matter. Empedocles (430 BC) argued that every thing in the universe is made up of a combination of four eternal "elements" or "roots of all": earth, water, air, and fire. All change is explained by the arrangement and rearrangement of these four elements. The various forms of life are caused by an appropriate mixture of elements. For example, growth in plants is explained by the natural downward movement of earth and the natural upward movement of fire.[6]
Democritus (460 BC), the disciple of Leucippus, thought that the essential characteristic of life is having a soul (psyche). In common with other ancient writers, he used the term to mean the principle of living things that causes them to function as a living thing. He thought the soul was composed of fire atoms, because of the apparent connection between life and heat, and because fire moves.[7] He suggested that humans originally lived like animals, gradually developing communities to help one another, originating language, and developing crafts and agriculture.[7]
In the scientific revolution of the 17th century, mechanistic ideas[clarification needed] were revived by philosophers like Descartes.[citation needed]
Hylomorphism is the theory (originating with Aristotle (322 BC)) that all things are a combination of matter and form. Aristotle was one of the first ancient writers to approach the subject of life in a scientific way. Biology was one of his main interests, and there is extensive biological material in his extant writings. According to him, all things in the material universe have both matter and form. The form of a living thing is its soul (Greek psyche, Latin anima). There are three kinds of souls: the "vegetative soul" of plants, which causes them to grow and decay and nourish themselves, but does not cause motion and sensation; the "animal soul" which causes animals to move and feel; and the rational soul which is the source of consciousness and reasoning which (Aristotle believed) is found only in man.[8] Each higher soul has all the attributes of the lower one. Aristotle believed that while matter can exist without form, form cannot exist without matter, and therefore the soul cannot exist without the body.[9]
Consistent with this account is a teleological explanation of life. A teleological explanation accounts for phenomena in terms of their purpose or goal-directedness. Thus, the whiteness of the polar bear's coat is explained by its purpose of camouflage. The direction of causality is the other way round from materialistic science, which explains the consequence in terms of a prior cause. Modern biologists reject this functional view in terms of a material and causal one: biological features are to be explained not by looking forward to future optimal results, but by looking backwards to the past evolutionary history of a species, which led to the natural selection of the features in question.[citation needed]
Vitalism is the belief that the life-principle is essentially immaterial. This originated with Stahl (17th century), and held sway until the middle of the 19th century. It appealed to philosophers such as Henri Bergson, Nietzsche, Wilhelm Dilthey, anatomists like Bichat, and chemists like Liebig.[citation needed]
Vitalism underpinned the idea of a fundamental separation of organic and inorganic material, and the belief that organic material can only be derived from living things. This was disproved in 1828 when Friedrich Wöhler prepared urea from inorganic materials.[10] This so-called Wöhler synthesis is considered the starting point of modern organic chemistry. It is of historical significance because for the first time an organic compound was produced from inorganic reactants.
Later,[when?] Helmholtz, anticipated by Mayer, demonstrated that no energy is lost in muscle movement, suggesting that there were no vital forces necessary to move a muscle. These empirical results led to the abandonment of scientific interest in vitalistic theories, although the belief lingered on in non-scientific theories such as homeopathy, which interprets diseases and sickness as caused by disturbances in a hypothetical vital force or life force.
It is a challenge for scientists and philosophers to define life in unequivocal terms.[11][12][13] Defining life is difficult—in part—because life is a process, not a pure substance.[14] Any definition must be sufficiently broad to encompass all life with which we are familiar, and it should be sufficiently general that, with it, scientists would not miss life that may be fundamentally different from life on Earth.[15]
Since there is no unequivocal definition of life, the current understanding is descriptive, where life is a characteristic of organisms that exhibit all or most of the following phenomena:[14][16]
- Homeostasis: Regulation of the internal environment to maintain a constant state; for example, electrolyte concentration or sweating to reduce temperature.
- Organization: Being structurally composed of one or more cells, which are the basic units of life.
- Metabolism: Transformation of energy by converting chemicals and energy into cellular components (anabolism) and decomposing organic matter (catabolism). Living things require energy to maintain internal organization (homeostasis) and to produce the other phenomena associated with life.
- Growth: Maintenance of a higher rate of anabolism than catabolism. A growing organism increases in size in all of its parts, rather than simply accumulating matter.
- Adaptation: The ability to change over a period of time in response to the environment. This ability is fundamental to the process of evolution and is determined by the organism's heredity as well as the composition of metabolized substances, and external factors present.
- Response to stimuli: A response can take many forms, from the contraction of a unicellular organism to external chemicals, to complex reactions involving all the senses of multicellular organisms. A response is often expressed by motion, for example, the leaves of a plant turning toward the sun (phototropism) and by chemotaxis.
- Reproduction: The ability to produce new individual organisms, either asexually from a single parent organism, or sexually from two parent organisms.
To reflect the minimum phenomena required, other biological definitions of life have been proposed.[17] Many of these proposals are based upon chemical systems. Living processes can be viewed as a delay of the spontaneous diffusion or dispersion of the internal energy of biological molecules towards more potential microstates.[18] At a higher level, living beings are thermodynamic systems that have an organized molecular structure.[18] Looking at it from a long-term perspective, life is matter that can reproduce itself and evolve as survival dictates.[19][20] Hence, life is a self-sustained chemical system capable of undergoing Darwinian evolution.[21]
Others take a systemic viewpoint that does not necessarily depend on molecular chemistry. One systemic definition of life is that living things are self-organizing and autopoietic (self-producing). Variations of this definition include Stuart Kauffman's definition as an autonomous agent or a multi-agent system capable of reproducing itself or themselves, and of completing at least one thermodynamic work cycle.[22] Life can be modeled as a network of inferior negative feedbacks of regulatory mechanisms subordinated to a superior positive feedback formed by the potential of expansion and reproduction.[23] From a simplified perspective, life can be said to consist of things with the capacity for metabolism and motion,[14] or that life is self-reproduction "with variations"[24][25] or "with an error rate below the sustainability threshold."[25]
Biophysicists have commented on the nature and qualities of life forms—notably that they function on negative entropy.[26][27] In more detail, according to physicists such as John Bernal, Erwin Schrödinger, Eugene Wigner, and John Avery, life is a member of the class of phenomena that are open or continuous systems able to decrease their internal entropy at the expense of substances or free energy taken in from the environment and subsequently rejected in a degraded form.[28][29][30]
Viruses are most often considered replicators rather than forms of life. They have been described as "organisms at the edge of life,"[31] since they possess genes, evolve by natural selection,[32] and replicate by creating multiple copies of themselves through self-assembly. However, viruses do not metabolize and they require a host cell to make new products. Virus self-assembly within host cells has implications for the study of the origin of life, as it may support the hypothesis that life could have started as self-assembling organic molecules.[33][34]
Some scientists have proposed in the last few decades[timeframe?] that a general living systems theory is required to explain the nature of life.[35] Such a general theory, arising out of the ecological and biological sciences, attempts to map general principles for how all living systems work. Instead of examining phenomena by attempting to break things down into component parts, a general living systems theory explores phenomena in terms of dynamic patterns of the relationships of organisms with their environment.[36]
The idea that the Earth is alive is probably as old as humankind, but the first public expression of it as a fact of science was by a Scottish scientist, James Hutton. In 1785 he stated that the Earth was a superorganism and that its proper study should be physiology. Hutton is rightly remembered as the father of geology, but his idea of a living Earth was forgotten in the intense reductionism of the 19th century.[37] The Gaia hypothesis, originally proposed in the 1960s by scientist James Lovelock,[38][39] explores the idea that the life on Earth functions as a single organism which defines and maintains environmental conditions necessary for its survival.[40]
Robert Rosen (1991) built on the assumption that the explanatory powers of the mechanistic worldview cannot help understand the realm of living systems. One of several important clarifications he made was to define a system component as "a unit of organization; a part with a function, i.e., a definite relation between part and whole." From this and other starting concepts, he developed a "relational theory of systems" that attempts to explain the special properties of life. Specifically, he identified the "nonfractionability of components in an organism" as the fundamental difference between living systems and "biological machines."[41]
A systems view of life treats environmental fluxes and biological fluxes together as a "reciprocity of influence",[42] and a reciprocal relation with environment is arguably as important for understanding life as it is for understanding ecosystems. As Harold J. Morowitz (1992) explains it, life is a property of an ecological system rather than a single organism or species.[43] He argues that an ecosystemic definition of life is preferable to a strictly biochemical or physical one. Robert Ulanowicz (2009) highlights mutualism as the key to understand the systemic, order-generating behavior of life and ecosystems.[44]
Main article:
Origin of lifeFor religious beliefs about the creation of life, see
Creation myth.
Evidence suggests that life on Earth has existed for about 3.7 billion years,[45] with the oldest traces of life found in fossils dating back 3.4 billion years.[46] All known life forms share fundamental molecular mechanisms, and based on these observations, theories on the origin of life attempt to find a mechanism explaining the formation of a primordial single cell organism from which all life originates. There are many different hypotheses regarding the path that might have been taken from simple organic molecules via pre-cellular life to protocells and metabolism. Many models fall into the "genes-first" category or the "metabolism-first" category, but a recent trend is the emergence of hybrid models that combine both categories.[47]
There is no scientific consensus as to how life originated and all proposed theories are highly speculative. However, most accepted scientific models build in one way or another on the following hypotheses:
Life as we know it today synthesizes proteins, which are polymers of amino acids using instructions encoded by cellular genes—which are polymers of deoxyribonucleic acid (DNA). Protein synthesis entails intermediary ribonucleic acid (RNA) polymers. One possibility is that genes came first and then proteins.[48] Another possibility is that proteins came first and then genes.[49] However, because genes are required to make proteins, and proteins are required to make genes, the problem of considering which came first is like that of the chicken or the egg. Most scientists have adopted the hypothesis that because DNA and proteins function together so intimately, it's unlikely that they arose independently.[50] Therefore, many scientists consider the possibility, apparently first suggested by Francis Crick,[51] that the first life was based on the DNA-protein intermediary: RNA.[50] In fact, RNA has the DNA-like properties of information storage, replication and the catalytic properties of some proteins. Crick and others actually favored the RNA-first hypothesis[52] even before the catalytic properties of RNA had been demonstrated by Thomas Cech.[53]
A significant issue with the RNA-first hypothesis is that experiments designed to synthesize RNA from simple precursors have not been nearly as successful as the Miller-Urey experiments that synthesized other organic molecules from inorganic precursors. One reason for the failure to create RNA in the laboratory is that RNA precursors are very stable and do not react with each other under ambient conditions. However, the successful synthesis of certain RNA molecules under conditions hypothesized to exist prior to life on Earth has been achieved by adding alternative precursors in a specified order with the precursor phosphate present throughout the reaction.[54] This study makes the RNA-first hypothesis more plausible to many scientists.[55]
Recent experiments have demonstrated true Darwinian evolution of unique RNA enzymes (ribozymes) made up of two separate catalytic components that replicate each other in vitro.[56] In describing this work from his laboratory, Gerald Joyce stated: "This is the first example, outside of biology, of evolutionary adaptation in a molecular genetic system."[57] Such experiments make the possibility of a primordial RNA world even more attractive to many scientists.
NASA findings in 2011, based on studies with meteorites found on Earth, suggest DNA and RNA components (adenine, guanine and related organic molecules) may be formed extraterrestrially in outer space.[58][59][60][61]
The diversity of life on Earth is a result of the dynamic interplay between genetic opportunity, metabolic capability, environmental challenges,[62] and symbiosis.[63][64][65] For most of its existence, Earth's habitable environment has been dominated by microorganisms and subjected to their metabolism and evolution. As a consequence of such microbial activities on a geologic time scale, the physical-chemical environment on Earth has been changing, thereby determining the path of evolution of subsequent life.[62] For example, the release of molecular oxygen by cyanobacteria as a by-product of photosynthesis induced fundamental, global changes in the Earth's environment. The altered environment, in turn, posed novel evolutionary challenges to the organisms present, which ultimately resulted in the formation of our planet's major animal and plant species. Therefore this "co-evolution" between organisms and their environment is apparently an inherent feature of living systems.[62]
All life forms require certain core chemical elements needed for biochemical functioning. These include carbon, hydrogen, nitrogen, oxygen, phosphorus, and sulfur—the elemental macronutrients for all organisms[66]—often represented by the acronym CHNOPS. Together these make up nucleic acids, proteins and lipids, the bulk of living matter. Five of these six elements comprise the chemical components of DNA; the exception being sulfur. The latter forms a component of the important amino acid methionine. The most essential of these elements is carbon, which has the desirable attribute of forming multiple, stable covalent bonds. This allows carbon-based (organic) molecules to form an immense variety of chemical arrangements.[67] Alternative hypothetical types of biochemistry have been proposed which eliminate one or more of these elements, swap out an element for one not on the list, or change required chiralities or other chemical properties.[citation needed]
The inert components of an ecosystem are the physical and chemical factors necessary for life—energy (sunlight or chemical energy), water, temperature, atmosphere, gravity, nutrients, and ultraviolet solar radiation protection.[68] In most ecosystems the conditions vary during the day and often shift from one season to the next. To live in most ecosystems, then, organisms must be able to survive a range of conditions, called the "range of tolerance."[69] Outside that are the "zones of physiological stress," where the survival and reproduction are possible but not optimal. Beyond these zones are the "zones of intolerance," where life for that organism is implausible. Organisms that have a wide range of tolerance are more widely distributed than organisms with a narrow range of tolerance.[69]
To survive, selected microorganisms can assume forms that enable them to withstand freezing, complete desiccation, starvation, high-levels of radiation exposure, and other physical or chemical challenges. These microorganisms may survive exposure to such conditions for weeks, months, years, or even centuries.[62] Extremophiles are microbial life forms that thrive outside the ranges where life is commonly found. They excel at exploiting uncommon sources of energy. While all organisms are composed of nearly identical molecules, evolution has enabled such microbes to cope with this wide range of physical and chemical conditions. Characterization of the structure and metabolic diversity of microbial communities in such extreme environments is ongoing.
Investigation of the tenacity and versatility of life on Earth, as well as an understanding of the molecular systems that some organisms utilize to survive such extremes, will provide a critical foundation for the search for life beyond Earth.[62] In this regard, on April 26, 2012, scientists reported that lichen survived and showed remarkable results on the adaptation capacity of photosynthetic activity within a simulated Martian environment.[70][71]
Cell theory propounds the concept that cells are the basic unit of structure in every living thing. This idea was formulated by Henri Dutrochet and others during the early nineteenth century, and subsequently became widely accepted.[72] According to this theory, all cells arise from pre-existing cells by division and the cell forms the fundamental unit of structure and function in all living organisms. The activity of an organism depends on the total activity of independent cells, with energy flow occurring within cells. Cells contain hereditary information that is carried forward as a genetic code during cell division. Cells belonging to similar species have basically the same chemical composition.
There are two primary types of cells. Prokaryotes lack a nucleus and other membrane-bound organelles, although they do they do have circular DNA and ribosomes. Bacteria and Archaea are two domains of prokaryotes. The other primary type of cells are the eukaryotes, which have distinct nuclei bound by a nuclear membrane and membrane-bound organelles, including mitochondria, chloroplasts, lysosomes, rough and smooth endoplasmic reticulum, and vacuoles. In addition, they possess organized chromosomes which store genetic material. All species of large complex organisms are eukaryotes, including animals, plants and fungi, although most species of eukaryote are protist microorganisms.[73]
The molecular mechanisms of cell biology is based around proteins. Most of these are synthesized by the ribosomes through an enzyme-catalyzed process called protein biosynthesis. A sequence of amino acids is assembled and joined together based upon gene expression of the cell's nucleic acid. In eukaryotic cells, these proteins may then be transported and processed through the Golgi apparatus in preparation for dispatch to their destination.
Multicellular organisms may have first evolved through the formation of colonies of like cells. These cells can form a group organism through cell adhesion. The individual members of a colony are capable of surviving on their own, whereas the members of a true multi-cellular organism have developed specialties, making them dependent on the remainder of the organism for survival. Such organisms are formed from a single germ cell, which is capable of forming the various specialized cells that form the adult organism.
Traditionally, people have divided organisms into the classes of plants and animals, based mainly on their ability of movement. The first known attempt to classify organisms was conducted by the Greek philosopher Aristotle (384–322 BC). He classified all living organisms known at that time as either a plant or an animal. Aristotle distinguished animals with blood from animals without blood (or at least without red blood), which can be compared with the concepts of vertebrates and invertebrates respectively. He divided the blooded animals into five groups: viviparous quadrupeds (mammals), birds, oviparous quadrupeds (reptiles and amphibians), fishes and whales. The bloodless animals were divided into five groups: cephalopods, crustaceans, insects (which included the spiders, scorpions, centipedes, and what we define as insects in the present day), shelled animals (such as most molluscs and echinoderms) and "zoophytes." Though Aristotle's work in zoology was not without errors, it was the grandest biological synthesis of the time and remained the ultimate authority for many centuries after his death.[74]
The exploration of the American continent revealed large numbers of new plants and animals that needed descriptions and classification. In the latter part of the 16th century and the beginning of the 17th, careful study of animals commenced and was gradually extended until it formed a sufficient body of knowledge to serve as an anatomical basis for classification.
In the late 1740s, Carolus Linnaeus introduced his method, still used, to formulate the scientific name of every species.[75] Linnaeus took every effort to improve the composition and reduce the length of the many-worded names by abolishing unnecessary rhetoric, introducing new descriptive terms and defining their meaning with an unprecedented precision. By consistently using his system, Linnaeus separated nomenclature from taxonomy. This convention for naming species is referred to as binomial nomenclature.
The fungi were originally treated as plants. For a short period Linnaeus had placed them in the taxon Vermes in Animalia. He later placed them back in Plantae. Copeland classified the Fungi in his Protoctista, thus partially avoiding the problem but acknowledged their special status.[76] The problem was eventually solved by Whittaker, when he gave them their own kingdom in his five-kingdom system. As it turned out, the fungi are more closely related to animals than to plants.[77]
As new discoveries enabled us to study cells and microorganisms, new groups of life were revealed, and the fields of cell biology and microbiology were created. These new organisms were originally described separately in protozoa as animals and protophyta/thallophyta as plants, but were united by Haeckel in his kingdom protista, later the group of prokaryotes were split off in the kingdom Monera, eventually this kingdom would be divided in two separate groups, the Bacteria and the Archaea, leading to the six-kingdom system and eventually to the current three-domain system.[78] The classification of eukaryotes is still controversial, with protist taxonomy especially problematic.[79]
As microbiology, molecular biology and virology developed, non-cellular reproducing agents were discovered, such as viruses and viroids. Sometimes these entities are considered to be alive but others argue that viruses are not living organisms since they lack characteristics such as cell membrane, metabolism and do not grow or respond to their environments. Viruses can however be classed into "species" based on their biology and genetics but many aspects of such a classification remain controversial.[80]
Since the 1960s a trend called cladistics has emerged, arranging taxa in an evolutionary or phylogenetic tree. It is unclear, should this be implemented, how the different codes will coexist.[81]
Earth is the only planet known to harbor life. The Drake equation, which predicts the number of extraterrestrial civilizations in our galaxy with which we might come in contact, has been used to discuss the probability of life elsewhere, but scientists disagree on many of the values of variables in this equation. Depending on those values, the equation may either suggest that life arises frequently or infrequently.[91]
The region around a main sequence star that could support Earth-like life on an Earth-like planet is known as the habitable zone. The inner and outer radii of this zone vary with the luminosity of the star, as does the time interval during which the zone will survive. Stars more massive than the Sun have a larger habitable zone, but will remain on the main sequence for a shorter time interval during which life can evolve. Small red dwarf stars have the opposite problem, with a smaller habitable zone that is subject to higher levels of magnetic activity and the effects of tidal locking from close orbits. Hence, stars in the intermediate mass range such as the Sun may have a greater likelihood for Earth-like life to develop.[92] The location of the star within a galaxy may have an impact on the likelihood of life forming. Stars in regions of a galaxy that have a greater abundance of heavier elements that can form planets, in combination with a low rate of potentially habitat-damaging supernova events, are predicted to have a higher probability of hosting planets with complex life.[93]
Panspermia, also called exogenesis, is a hypothesis proposing that life originated elsewhere in the universe and was subsequently transferred to Earth in the form of spores perhaps via meteorites, comets or cosmic dust. In October 2011, scientists found that the cosmic dust permeating the universe contains complex organic matter ("amorphous organic solids with a mixed aromatic-aliphatic structure") that could be created naturally, and rapidly, by stars.[94][95][96] As one of the scientists noted, "Coal and kerogen are products of life and it took a long time for them to form ... How do stars make such complicated organics under seemingly unfavorable conditions and [do] it so rapidly?"[94] Further, the scientist suggested that these compounds may have been related to the development of life on earth and said that, "If this is the case, life on Earth may have had an easier time getting started as these organics can serve as basic ingredients for life."[94]
Death is the permanent termination of all vital functions or life processes in an organism or cell.[97][98] After death, the remains of an organism become part of the biogeochemical cycle. Organisms may be consumed by a predator or a scavenger and leftover organic material may then be further decomposed by detritivores, organisms which recycle detritus, returning it to the environment for reuse in the food chain.
One of the challenges in defining death is in distinguishing it from life. Death would seem to refer to either the moment at which life ends, or when the state that follows life begins.[98] However, determining when death has occurred requires drawing precise conceptual boundaries between life and death. This is problematic, however, because there is little consensus over how to define life. The nature of death has for millennia been a central concern of the world's religious traditions and of philosophical inquiry. Many religions maintain faith in either a kind of afterlife or reincarnation for the soul, or resurrection of the body at a later date.
Extinction is the gradual process by which a group of taxa or species dies out, reducing biodiversity.[99] The moment of extinction is generally considered to be the death of the last individual of that species. Because a species' potential range may be very large, determining this moment is difficult, and is usually done retrospectively after a period of apparent absence. Species become extinct when they are no longer able to survive in changing habitat or against superior competition. Over the history of the Earth, over 99% of all the species that have ever lived have gone extinct;[100] however, mass extinctions may have accelerated evolution by providing opportunities for new groups of organisms to diversify.[101]
Fossils are the preserved remains or traces of animals, plants, and other organisms from the remote past. The totality of fossils, both discovered and undiscovered, and their placement in fossil-containing rock formations and sedimentary layers (strata) is known as the fossil record. Such a preserved specimen is called a "fossil" if it is older than the arbitrary date of 10,000 years ago.[102] Hence, fossils range in age from the youngest at the start of the Holocene Epoch to the oldest from the Archaean Eon, up to 3.4 billion years old.[103][104]
- ^ The 'evolution' of viruses and other similar forms is still uncertain. Therefore, this classification may be paraphyletic because cellular life might have evolved from non-cellular life, or polyphyletic because the most recent common ancestor might not be included.
- ^ a b Koshland Jr, Daniel E. (March 22, 2002). "The Seven Pillars of Life". Science 295 (5563): 2215–2216. DOI:10.1126/science.1068489. PMID 11910092. http://www.sciencemag.org/cgi/content/full/295/5563/2215. Retrieved 2009-05-25.
- ^ The American Heritage Dictionary of the English Language, 4th edition, published by Houghton Mifflin Company, via Answers.com:
- "The property or quality that distinguishes living organisms from dead organisms and inanimate matter, manifested in functions such as metabolism, growth, reproduction, and response to stimuli or adaptation to the environment originating from within the organism."
- "The characteristic state or condition of a living organism."
- ^ Definition of inanimate. WordNet Search by Princeton University.
- ^ "Merriam-Webster Dictionary". Merriam-Webster Dictionary. http://www.merriam-webster.com/dictionary/life. Retrieved 2009-06-21.
- ^ "organism". Chambers 21st Century Dictionary (online ed.). Chambers Publishers Ltd. 1999. http://www.chambersharrap.co.uk/chambers/features/chref/chref.py/main?query=organism&title=21st. Retrieved 2012-05-26.
- ^ Parry, Richard (March 4, 2005). "Empedocles". Stanford Encyclopedia of Philosophy. http://plato.stanford.edu/entries/empedocles/. Retrieved 2012-05-25.
- ^ a b Parry, Richard (August 25, 2010). "Democritus". Stanford Encyclopedia of Philosophy. http://plato.stanford.edu/entries/democritus/#4. Retrieved 2012-05-25.
- ^ Aristotle, De Anima, Book II
- ^ Marietta, Don (1998). Introduction to ancient philosophy. M. E. Sharpe. p. 104. ISBN 0765602164. http://books.google.com/books/about/Introduction_to_Ancient_Philosophy.html?id=Gz-8PsrT32AC.
- ^ Friedrich Wöhler (1828). "Ueber künstliche Bildung des Harnstoffs". Annalen der Physik und Chemie 88 (2): 253–256. Bibcode 1828AnP....88..253W. DOI:10.1002/andp.18280880206. http://gallica.bnf.fr/ark:/12148/bpt6k15097k/f261.chemindefer.
- ^ Mullen, Leslie (June 19, 2002). "Defining Life". Origin & Evolution of Life. http://www.astrobio.net/exclusive/226/defining-life. Retrieved 2012-05-25.
- ^ Emmeche, Claus (1997). "Defining Life, Explaining Emergence". Niels Bohr Institute. http://www.nbi.dk/~emmeche/cePubl/97e.defLife.v3f.html. Retrieved 2012-05-25.
- ^ "Can We Define Life". Colorado Arts & Sciences. 2009. http://artsandsciences.colorado.edu/magazine/2009/03/can-we-define-life/. Retrieved 2009-06-22.
- ^ a b c McKay, Chris P. (September 14, 2004). "What Is Life—and How Do We Search for It in Other Worlds?". Public Library of Science – Biology 2 (2(9)): 302. DOI:10.1371/journal.pbio.0020302. PMC 516796. PMID 15367939. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=516796.
- ^ Nealson, K. H.; Conrad, P. G. (December 1999). "Life: past, present and future". Philosophical Transactions of the Royal Society of London B Biological Sciences 354 (1392): 1923–39. DOI:10.1098/rstb.1999.0532. PMC 1692713. PMID 10670014. http://journals.royalsociety.org/content/7r10hqn3rp1g1vag/fulltext.pdf.
- ^ Davison, Paul G.. "How to Define Life". The University of North Alabama. http://www2.una.edu/pdavis/BI%20101/Overview%20Fall%202004.htm. Retrieved 2008-10-17.
- ^ Popa, Radu (March 2004). Between Necessity and Probability: Searching for the Definition and Origin of Life (Advances in Astrobiology and Biogeophysics). Springer. ISBN 3-540-20490-3. http://www.amazon.com/Between-Necessity-Probability-Astrobiology-Biogeophysics/dp/3540204903.
- ^ a b Nahle, Nasif Sabag (September 26, 2006). "Astrobiology". Biology Cabinet Organization. http://biocab.org/Astrobiology.html. Retrieved 2011-01-17.
- ^ Luttermoser, Donald G.. "ASTR-1020: Astronomy II Course Lecture Notes Section XII" (PDF). East Tennessee State University. http://www.etsu.edu/physics/lutter/courses/astr1020/a1020chap12.pdf. Retrieved 2011-08-28.
- ^ Luttermoser, Donald G. (Spring 2008). "Physics 2028: Great Ideas in Science: The Exobiology Module" (PDF). East Tennessee State University. http://www.etsu.edu/physics/lutter/courses/phys2028/p2028exobnotes.pdf. Retrieved 2011-08-28.
- ^ Joyce, Gerald F. (1995). The RNA world: life before DNA and protein. Cambridge University Press. pp. 139-151. DOI:10.1017/CBO9780511564970.017. http://ebooks.cambridge.org/chapter.jsf?bid=CBO9780511564970&cid=CBO9780511564970A022. Retrieved 2012-05-27.
- ^ Kaufmann, Stuart (2004). Barrow, John D.; Davies; Harper Jr., C. L.. eds. "Autonomous agents". Science and Ultimate Reality: Quantum Theory, Cosmology, and Complexity (Cambridge University Press): 654–666. ISBN 052183113X. http://books.google.com/books?id=K_OfC0Pte_8C&pg=PA654.
- ^ Korzeniewski, Bernard (April 7, 2001). "Cybernetic formulation of the definition of life". Journal of Theoretical Biology 209 (3): 275–86. DOI:10.1006/jtbi.2001.2262. PMID 11312589.
- ^ Trifonov, Edward N.. "Definition of Life: Navigation through Uncertainties". Journal of Biomolecular Structure & Dynamics (Adenine Press) 29 (4): 647–650. ISSN 0739-1102. http://www.jbsdonline.com/mc_images/category/4317/21-trifonov-jbsd_29_4_2012.pdf. Retrieved 2012-01-12.
- ^ a b Zimmer, Carl (January 11, 2012). "Can scientists define 'life' ... using just three words?". MSN. http://www.msnbc.msn.com/id/45963181/ns/technology_and_science/. Retrieved 2012-01-12.
- ^ Schrödinger, Erwin (1944). What is Life?. Cambridge University Press. ISBN 0-521-42708-8.
- ^ Margulis, Lynn; Sagan, Dorion (1995). What is Life?. University of California Press. ISBN 0-520-22021-8.
- ^ Lovelock, James (2000). Gaia – a New Look at Life on Earth. Oxford University Press. ISBN 0-19-286218-9.
- ^ Avery, John (2003). Information Theory and Evolution. World Scientific. ISBN 981-238-399-9.
- ^ Nahle, Nasif Sabag (September 29, 2006). "Biophysics: definition of life and brief explanation of each term". Exobiology. Biology Cabinet Organization. http://www.biocab.org/Exobiology.html#anchor_41. Retrieved 2012-05-27.
- ^ Rybicki, EP (1990). "The classification of organisms at the edge of life, or problems with virus systematics". S Aft J Sci 86: 182–186.
- ^ Holmes, E. C. (October 2007). "Viral evolution in the genomic age". PLoS Biol. 5 (10): e278. DOI:10.1371/journal.pbio.0050278. PMC 1994994. PMID 17914905. http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050278. Retrieved 2008-09-13.
- ^ Koonin, E. V.; Senkevich, T. G.; Dolja, V. V. (2006). "The ancient Virus World and evolution of cells". Biology Direct 1: 29. DOI:10.1186/1745-6150-1-29. PMC 1594570. PMID 16984643. http://www.biology-direct.com/content/1//29. Retrieved 2008-09-14.
- ^ Rybicki, Ed (November 1997). "Origins of Viruses". http://www.mcb.uct.ac.za/tutorial/virorig.html#Virus%20Origins. Retrieved 2009-04-12.
- ^ Woodruff, T. Sullivan; John Baross (October 8, 2007). Planets and Life: The Emerging Science of Astrobiology. Cambridge University Press. ISBN 0521824214. Cleland and Chyba wrote a chapter in Planets and Life: "In the absence of such a theory, we are in a position analogous to that of a 16th-century investigator trying to define 'water' in the absence of molecular theory." [...] "Without access to living things having a different historical origin, it is difficult and perhaps ultimately impossible to formulate an adequately general theory of the nature of living systems".
- ^ Brown, Molly Young (2002). "Patterns, flows, and interrelationship". Psychosynthesis and Ecopsychology. http://mollyyoungbrown.com/essays-books-on-psychosynthesis-and-ecopsychology/essays/httpmollyyoungbrown-comessays-books-on-psychosynthesis-and-ecopsychologyessayspatterns-flows-interrelationship/. Retrieved 2012-05-27.
- ^ Lovecock, James (1979). GAIA – A new look at life on Earth. Oxford University Press. p. 10. ISBN 0-19-286030-5.
- ^ Lovelock, J. E. (1965). "A physical basis for life detection experiments". Nature 207 (7): 568–570. Bibcode 1965Natur.207..568L. DOI:10.1038/207568a0. PMID 5883628.
- ^ Lovelock, James. "Geophysiology". Papers by James Lovelock. http://www.jameslovelock.org/page4.html#GEO.
- ^ Lovelock, James (1979). GAIA – A new look at life on Earth. Oxford University Press. ISBN 0-19-286030-5. http://books.google.com/books/about/Gaia.html?id=89GBVioWGUgC.
- ^ Robert, Rosen (November 1991). Life Itself: A Comprehensive Inquiry into the Nature, Origin, and Fabrication of Life. ISBN 978-0-231-07565-7.
- ^ "The Ecosystemic Life Hypothesis". Bulletin of the Ecological Society of America. April 2002. http://www.calresco.org/fiscus/esl.htm. Retrieved 2009-08-28.
- ^ Morowitz, Harold J. (1992). Beginnings of cellular life: metabolism recapitulates biogenesis. Yale University Press. ISBN 0-300-05483-1. http://books.google.com/books?id=CmQDSHN_UrIC.
- ^ Ulanowicz, Robert W.; Ulanowicz, Robert E. (2009). A third window: natural life beyond Newton and Darwin. Templeton Foundation Press. ISBN 1-59947-154-X. http://books.google.com/books?id=gAQKAQAAMAAJ.
- ^ "History of life through time". University of California Museum of Paleontology. http://www.ucmp.berkeley.edu/exhibits/historyoflife.php. Retrieved 2012-05-26.
- ^ Dean, Tim (August 23, 2011). "World’s oldest fossils reveal earliest life on Earth". Australian Life Scientist. IDG Communications. http://www.lifescientist.com.au/article/398092/world_oldest_fossils_reveal_earliest_life_earth. Retrieved 2012-05-26.
- ^ Coveney, Peter V.; Fowler, Philip W. (2005). "Modelling biological complexity: a physical scientist's perspective". Journal of the Royal Society Interface 2 (4): 267–280. DOI:10.1098/rsif.2005.0045.
- ^ Senapathy, Periannan (1994). Independent birth of organisms. Madison, WI: Genome Press. ISBN 0964130408. http://books.google.com/books?id=3hJFAQAAIAAJ.
- ^ Eigen, Manfred; Winkler, Ruthild (1992). Steps towards life: a perspective on evolution (German edition, 1987). Oxford University Press. p. 31. ISBN 019854751X. http://books.google.com/books/about/Steps_towards_life.html?id=R7QTAQAAIAAJ.
- ^ a b Barazesh, Solmaz (May 13, 2009). "How RNA Got Started: Scientists Look for the Origins of Life". Science News. http://www.usnews.com/science/articles/2009/05/13/how-rna-got-started-scientists-examine-the-origins-of-life. Retrieved 2012-05-25.
- ^ Watson, James D. (1993). Gesteland, R. F.; Atkins, J. F.. eds. Prologue: early speculations and facts about RNA templates. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press. pp. xv–xxiii.
- ^ Gilbert, Walter (February 20, 1986). "Origin of life: The RNA world". Nature 319 (618). DOI:10.1038/319618a0.
- ^ Cech, Thomas R. (1986). "A model for the RNA-catalyzed replication of RNA". Procedings of the National Academy of Science USA 83: 4360-4363. http://www.pnas.org/content/83/12/4360.abstract. Retrieved 2012-05-25.
- ^ Powner, Matthew W.; Gerland, Béatrice; Sutherland, John D. (May 14, 2009). "Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions". Nature 459: 239–242. DOI:10.1038/nature08013.
- ^ Szostak, Jack W. (May 14, 2009). "Origins of life: Systems chemistry on early Earth". Nature 459: 171–172. DOI:10.1038/459171a.
- ^ Lincoln, Tracey A.; Joyce, Gerald F. (February 27, 2009). "Self-Sustained Replication of an RNA Enzyme". Science 323 (5918): 1229–1232. DOI:10.1126/science.1167856.
- ^ Joyce, Gerald F.. "Evolution in an RNA world". Cold Spring Harbor Symposium on Quantitative Biology. DOI:10.1101/sqb.2009.74.004. PMC 2891321. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2891321.
- ^ Callahan; Smith, K.E.; Cleaves, H.J.; Ruzica, J.; Stern, J.C.; Glavin, D.P.; House, C.H.; Dworkin, J.P. (August 11, 2011). "Carbonaceous meteorites contain a wide range of extraterrestrial nucleobases". PNAS. DOI:10.1073/pnas.1106493108. http://www.pnas.org/content/early/2011/08/10/1106493108. Retrieved 2011-08-15.
- ^ Steigerwald, John (August 8, 2011). "NASA Researchers: DNA Building Blocks Can Be Made in Space". NASA. http://www.nasa.gov/topics/solarsystem/features/dna-meteorites.html. Retrieved 2011-08-10.
- ^ ScienceDaily Staff (August 9, 2011). "DNA Building Blocks Can Be Made in Space, NASA Evidence Suggests". ScienceDaily. http://www.sciencedaily.com/releases/2011/08/110808220659.htm. Retrieved 2011-08-09.
- ^ Gallori, Enzo (November 2010). "Astrochemistry and the origin of genetic material". Rendiconti Lincei 22 (2): 113–118. DOI:10.1007/s12210-011-0118-4. http://www.springerlink.com/content/x332837483630g24/. Retrieved 2011-08-11.
- ^ a b c d e Rothschild, Lynn (September, 2003). "Understand the evolutionary mechanisms and environmental limits of life". NASA. http://astrobiology.arc.nasa.gov/roadmap/g5.html. Retrieved 2009-07-13.
- ^ King, G.A.M. (April, 1977). "Symbiosis and the origin of life". Origins of Life and Evolution of Biospheres 8 (1): 39–53. Bibcode 1977OrLi....8...39K. DOI:10.1007/BF00930938. http://www.springerlink.com/content/n10p775113175l67/. Retrieved 2010-02-22.
- ^ Margulis, Lynn (2001). The Symbiotic Planet: A New Look at Evolution. London, England: Orion Books Ltd.. ISBN 0-7538-0785-8.
- ^ Douglas J. Futuyma; Janis Antonovics (1992). Oxford surveys in evolutionary biology: Symbiosis in evolution. 8. London, England: Oxford University Press. pp. 347–374. ISBN 0-19-507623-0.
- ^ Hotz, Robert Lee (December 3, 2010). "New link in chain of life". Wall Street Journal (Dow Jones & Company, Inc). http://online.wsj.com/article/SB10001424052748703377504575650840897300342.html?mod=ITP_pageone_1#printMode. ""Until now, however, they were all thought to share the same biochemistry, based on the Big Six, to build proteins, fats and DNA.""
- ^ Neuhaus, Scott (2005), Handbook for the Deep Ecologist: What Everyone Should Know About Self, the Environment, And the Planet, iUniverse, pp. 23–50, ISBN 059535789X, http://books.google.com/books?id=uzBDQPxe6zsC&pg=PA23
- ^ "Essential requirements for life". CMEX-NASA. http://cmapsnasacmex.ihmc.us/servlet/SBReadResourceServlet?rid=1025200161109_2045745605_1714&partName=htmltext. Retrieved 2009-07-14.
- ^ a b Chiras, Daniel C. (2001). Environmental Science – Creating a Sustainable Future (6th ed.). ISBN 0763713163.
- ^ Baldwin, Emily (April 26, 2012). "Lichen survives harsh Mars environment". Skymania News. http://www.skymania.com/wp/2012/04/lichen-survives-harsh-martian-setting.html. Retrieved 27 April 2012.
- ^ de Vera, J.-P.; Kohler, Ulrich (April 26, 2012). "The adaptation potential of extremophiles to Martian surface conditions and its implication for the habitability of Mars". European Geosciences Union. http://media.egu2012.eu/media/filer_public/2012/04/05/10_solarsystem_devera.pdf. Retrieved 27 April 2012.
- ^ Sapp, Jan (2003), [books.google.com/books?id=f4kXJv1XiFUC&pg=PA75 Genesis: The Evolution of Biology], Oxford University Press, pp. 75–78, ISBN 0195156196, books.google.com/books?id=f4kXJv1XiFUC&pg=PA75
- ^ Whitman, W.; Coleman, D.; Wiebe, W. (1998). "Prokaryotes: The unseen majority". Procedings of the National Academy of Science of the United States of America 95 (12): 6578–83. Bibcode 1998PNAS...95.6578W. DOI:10.1073/pnas.95.12.6578. PMC 33863. PMID 9618454. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=33863.
- ^ "Aristotle -biography". University of California Museum of Paleontology. http://www.ucmp.berkeley.edu/history/aristotle.html. Retrieved 2008-10-20.
- ^ Knapp S, Lamas G, Lughadha EN, Novarino G (April 2004). "Stability or stasis in the names of organisms: the evolving codes of nomenclature". Philosophical transactions of the Royal Society of London. Series B, Biological sciences 359 (1444): 611–22. DOI:10.1098/rstb.2003.1445. PMC 1693349. PMID 15253348. http://journals.royalsociety.org/openurl.asp?genre=article&issn=0962-8436&volume=359&issue=1444&spage=611.
- ^ a b Copeland, H.F. (1938). "The Kingdoms of Organisms". Quarterly Review of Biology 13 (4): 383. DOI:10.1086/394568. JSTOR 2808554.
- ^ Whittaker, R. H. (January 1969). "New concepts of kingdoms or organisms. Evolutionary relations are better represented by new classifications than by the traditional two kingdoms". Science 163 (3863): 150–60. Bibcode 1969Sci...163..150W. DOI:10.1126/science.163.3863.150. PMID 5762760.
- ^ a b Woese, C.; Kandler, O.; Wheelis, M. (1990). "Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya.". Proceedings of the National Academy of Sciences of the United States of America 87 (12): 4576–9. Bibcode 1990PNAS...87.4576W. DOI:10.1073/pnas.87.12.4576. PMC 54159. PMID 2112744. http://www.pnas.org/cgi/reprint/87/12/4576.
- ^ Adl SM, Simpson AG, Farmer MA, et al. (2005). "The new higher level classification of eukaryotes with emphasis on the taxonomy of protists". J. Eukaryot. Microbiol. 52 (5): 399–451. DOI:10.1111/j.1550-7408.2005.00053.x. PMID 16248873.
- ^ Van Regenmortel MH (January 2007). "Virus species and virus identification: past and current controversies". Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases 7 (1): 133–44. DOI:10.1016/j.meegid.2006.04.002. PMID 16713373.
- ^ Pennisi E (March 2001). "Taxonomy. Linnaeus's last stand?". Science (New York, N.Y.) 291 (5512): 2304–7. DOI:10.1126/science.291.5512.2304. PMID 11269295.
- ^ Linnaeus, C. (1735). Systemae Naturae, sive regna tria naturae, systematics proposita per classes, ordines, genera & species.
- ^ Haeckel, E. (1866). Generelle Morphologie der Organismen. Reimer, Berlin.
- ^ Chatton, É. (1925). "Pansporella perplexa. Réflexions sur la biologie et la phylogénie des protozoaires". Annales des Sciences Naturelles - Zoologie et Biologie Animale 10-VII: 1–84.
- ^ Chatton, É. (1937). Titres et Travaux Scientifiques (1906–1937). Sette, Sottano, Italy.
- ^ Copeland, H. F. (1956). The Classification of Lower Organisms. Palo Alto: Pacific Books. DOI:10.5962/bhl.title.4474.
- ^ Whittaker, R. H. (January 1969). "New concepts of kingdoms of organisms". Science 163 (3863): 150–60. DOI:10.1126/science.163.3863.150. PMID 5762760.
- ^ Woese, C. R.; Balch, W. E.; Magrum, L. J.; Fox, G. E.; Wolfe, R. S. (August 1977). "An ancient divergence among the bacteria". Journal of Molecular Evolution 9 (4): 305–311. DOI:10.1007/BF01796092. PMID 408502.
- ^ Woese, C. R.; Fox, G. E. (November 1977). "Phylogenetic structure of the prokaryotic domain: the primary kingdoms". Proceedings of the National Academy of Sciences of the United States of America 74 (11): 5088–90. DOI:10.1073/pnas.74.11.5088. PMC 432104. PMID 270744. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=432104.
- ^ Cavalier-Smith, T. (2004), "Only six kingdoms of life", Proceedings of the Royal Society of London B Biological Sciences 271: 1251–62, DOI:10.1098/rspb.2004.2705, PMC 1691724, PMID 15306349, http://www.cladocera.de/protozoa/cavalier-smith_2004_prs.pdf, retrieved 2010-04-29
- ^ Vakoch, Douglas A.; Harrison, Albert A. (2011). Civilizations beyond Earth: extraterrestrial life and society. Berghahn Series. Berghahn Books. pp. 37–41. ISBN 0857452118. http://books.google.com/?id=BVJzsvqWip0C&pg=PA37
- ^ Selis, Frank (2006). "Habitability: the point of view of an astronomer". In Gargaud, Muriel; Martin, Hervé; Claeys, Philippe. Lectures in Astrobiology. 2. Springer. pp. 210–214. ISBN 3540336923. http://books.google.com/books?id=3uYmP0K5PXEC&pg=PA210
- ^ Lineweaver, Charles H.; Fenner, Yeshe; Gibson, Brad K. (January 2004). "The Galactic Habitable Zone and the age distribution of complex life in the Milky Way". Science 303 (5654): 59–62. Bibcode 2004Sci...303...59L. DOI:10.1126/science.1092322. PMID 14704421
- ^ a b c Chow, Denise (October 26, 2011). "Discovery: Cosmic Dust Contains Organic Matter from Stars". Space.com. http://www.space.com/13401-cosmic-star-dust-complex-organic-compounds.html. Retrieved 2011-10-26.
- ^ ScienceDaily Staff (October 26, 2011). "Astronomers Discover Complex Organic Matter Exists Throughout the Universe". ScienceDaily. http://www.sciencedaily.com/releases/2011/10/111026143721.htm. Retrieved 2011-10-27.
- ^ Kwok, Sun; Zhang, Yong (October 26, 2011). "Mixed aromatic–aliphatic organic nanoparticles as carriers of unidentified infrared emission features". Nature 479 (7371): 80. Bibcode 2011Natur.479...80K. DOI:10.1038/nature10542.
- ^ "Definition of death". Definition of death. Archived from the original on 2009-10-31. http://www.webcitation.org/5kwsdvU8f.
- ^ a b "Definition of death". Encyclopedia of Death and Dying. Advameg, Inc.. http://www.deathreference.com/Da-Em/Definitions-of-Death.html. Retrieved 2012-05-25.
- ^ "Extinction – definition". Extinction – definition. Archived from the original on 2009-10-31. http://www.webcitation.org/5kwseRB80.
- ^ "What is an extinction?". Late Triassic. Bristol University. http://palaeo.gly.bris.ac.uk/Palaeofiles/Triassic/extinction.htm. Retrieved 2012-06-5-27.
- ^ Van Valkenburgh, B. (1999). "Major patterns in the history of carnivorous mammals". Annual Review of Earth and Planetary Sciences 27: 463–493. Bibcode 1999AREPS..27..463V. DOI:10.1146/annurev.earth.27.1.463.
- ^ "Frequently asked questions". San Diego Natural History Museum. http://www.sdnhm.org/science/paleontology/resources/frequent/. Retrieved 2012-05-25.
- ^ Vastag, Brian (August 21, 2011). "Oldest 'microfossils' raise hopes for life on Mars". The Washington Post. http://www.washingtonpost.com/national/health-science/oldest-microfossils-hail-from-34-billion-years-ago-raise-hopes-for-life-on-mars/2011/08/19/gIQAHK8UUJ_story.html?hpid=z3. Retrieved 2011-08-21.
- ^ Wade, Nicholas (August 21, 2011). "Geological Team Lays Claim to Oldest Known Fossils". The New York Times. http://www.nytimes.com/2011/08/22/science/earth/22fossil.html?_r=1&partner=rss&emc=rss&src=ig. Retrieved 2011-08-21.
![Michael J. Fox Life-Love+Parkinson's Interview 2012 [HD] 7](http://web.archive.org./web/20131013121624im_/http://i.ytimg.com/vi/vZQhp3yEgYM/default.jpg "Michael J. Fox Life-Love+Parkinson's Interview 2012 [HD] 7")
![[Comercial] FoxLife - Queer Eye For The Straight Guy and Girl](http://web.archive.org./web/20131013121624im_/http://i.ytimg.com/vi/OgBJ48lqo3U/default.jpg "[Comercial] FoxLife - Queer Eye For The Straight Guy and Girl")
17% 
Texts on Wikisource:
.jpg){kind=link}