In 623, Muhammad, Prophet of Islam, told Ali that God ordered him to give his daughter Fatimah Zahra to Ali in marriage. Muhammad said to Fatimah: "I have married you to the dearest of my family to me." This family is glorified by Muhammad frequently and he declared them as his Ahl al-Bayt in events such as Mubahala and hadith like the Hadith of the Event of the Cloak. They were also glorified in the Qur'an in several cases such as "the verse of purification".

Ali had four children born to Fatimah, the only child of Muhammad to have progeny. They are Hasan, Husayn, Zaynab and Umm Kulsum.

Their two sons (Hasan and Husain) were cited by Muhammad to be his own sons, honored numerous times in his lifetime and titled "the leaders of the youth of Jannah" (Heaven, the hereafter.)

Their marriage lasted until Fatimah's death ten years later. Although polygamy was permitted, Ali did not marry another woman while Fatimah was alive, and his marriage to her possesses a special spiritual significance for all Muslims because it is seen as the marriage between two great figures surrounding Muhammad. After Fatimah's death, Ali married other wives and fathered many children.

Alī ibn Abī Ṭālib (Arabic: علي بن أﺑﻲ طالب, Transliteration: ʿAlī ibn Abī Ṭālib, [ʕaliː ibn ʔæbiː t̪ˤɑːlib]; 13^thRajab, 24 BH–21^stRamaḍān, 40 AH; approximately October 23, 598 or 600 or March 17, 599 – January 27, 661). The son of Abu Talib, Ali was also the cousin and son-in-law of Islamic prophet Muhammad, ruling over the Islamic Caliphate from 656 to 661, and was the first male convert to Islam.Sunnis consider Ali the fourth and final of the Rashidun (rightly guided Caliphs), while Shias regard Ali as the first Imam and consider him and his descendants the rightful successors to Muhammad, all of which are members of the Ahl al-Bayt, the household of Muhammad. This disagreement split the Ummah (Muslim community) into the Sunni and Shia branches.

Muslim sources, especially Shia ones, state that since Muhammad's time, Ali was the only person born in the Kaaba sanctuary in Mecca, the holiest place in Islam. His father was Abu Talib and his mother was Fatima bint Asad, but he was raised in the household of Muhammad, who himself was raised by Abu Talib, Muhammad's uncle, and Ali's father. When Muhammad reported receiving a divine revelation, Ali was the first male to accept his message, dedicating his life to the cause of Islam.

Nouman Ali Khan is a Muslim speaker and the CEO and founder of Bayyinah, an Islamic educational institution in the United States.

His early education in Arabic started under in Riyadh, Saudi Arabia and continued in Pakistan. His serious Arabic training began in 1999 in the United States. He has been teaching Modern Standard and Classical Arabic at various venues for several years with over 10,000 students nationwide. Nouman Ali Khan teaches about the religion of Islam through his video speeches. He also frequently speaks at Islamic Circle of North America Conventions about Islam, family, and other life topics.