The 2010 Yushu earthquake struck on April 14, 2010, and registered a magnitude of 6.9M_w (USGS, EMSC) or 7.1M_s (CEA, CENC). It originated in Yushu, Qinghai, China, at 7:49 am local time. According to the Xinhua News Agency, 2,698 people have been confirmed dead, 270 missing, and 12,135 injured of which 1,434 are severely injured. The epicenter was located in Rima village (日玛村/日麻村), Upper Laxiu township (上拉秀乡) of Yushu County, in remote and rugged terrain, near the border of Tibet Autonomous Region. The epicenter is about 30 km from Gyêgu town or Jyekundo, the seat of Yushu County, and about 240 km from Qamdo. The epicenter was in a sparsely populated area on the Tibetan plateau that is regularly hit by earthquakes.

The 12th century Thrangu Monastery and surrounding villages were severely damaged and many monks and villagers were killed.

Qinghai lies in the northeastern part of the Tibetan Plateau, which formed due to the ongoing collision of the Indian Plate with the Eurasian Plate. The main deformation in this area is crustal shortening, but there is also a component of left lateral strike-slip faulting on major west–east trending structures such as the Kunlun and Altyn Tagh fault systems that accommodate southeastward translation of the Tibetan area.

The Dalai Lama is a high lama in the Gelug or "Yellow Hat" branch of Tibetan Buddhism. The name is a combination of the Sino-Mongolian word далай (dalai) meaning "Ocean" and the Tibetan word བླ་མ་ bla-ma (with a silent "b") meaning "chief, high priest".

In religious terms, the Dalai Lama is believed by his devotees to be the rebirth of a long line of tulkus who are considered to be manifestations of the bodhisattva of compassion, Avalokiteśvara. Traditionally, the Dalai Lama is thought of as the latest reincarnation of a series of spiritual leaders who have chosen to be reborn in order to enlighten others. The Dalai Lama is often thought to be the leader of the Gelug School, but this position belongs officially to the Ganden Tripa, which is a temporary position appointed by the Dalai Lama who, in practice, exerts much influence. The line of Dalai Lamas began as a lineage of spiritual teachers; the 5th Dalai Lama assumed political authority over Tibet.

For certain periods between the 17th century and 1959, the Dalai Lamas sometimes directed the Tibetan government, which administered portions of Tibet from Lhasa. The 14th Dalai Lama remained the head of state for the Central Tibetan Administration ("Tibetan government in exile") until his retirement on March 14, 2011. He has indicated that the institution of the Dalai Lama may be abolished in the future, and also that the next Dalai Lama may be found outside Tibet and may be female. The Chinese government was very quick to reject this and claimed that only it has the authority to select the next Dalai Lama.