The 1854 revolt in Epirus was one of the most important of a series of Greek uprisings that occurred in the Ottoman-occupied Greek world during that period. When the Crimean War (1854–1856) broke out, many Epirote Greeks, with tacit support from the Greek state, revolted against the Ottoman rule. Although this movement was supported by distinguished military personalities, the correlation of forces doomed it from the start, leading to its suppression after a few months.

When the Crimean War broke out between the Ottoman Empire and Russia, many Greeks felt that it was an opportunity to gain lands inhabited by Greeks but not included in the independent Kingdom of Greece. The Greek War of Independence (1821–1829) was still fresh in their minds, as well as the Russian intervention that had helped secure Greek independence. Furthermore, Greeks had traditionally looked to help from fellow-Orthodox Russia.

Although the official Greek state, under severe diplomatic and military pressure from the British and French (allies of the Ottomans), refrained from actively entering the conflict, a number of uprisings were organized in Epirus, Thessaly, Crete, with support from individuals and groups within independent Greece.

Epirus /ɨˈpaɪərəs/ is a geographical and historical region in southeastern Europe, shared between Greece and Albania. It lies between the Pindus Mountains and the Ionian Sea, stretching from the Bay of Vlorë in the north to the Ambracian Gulf in the south. It is currently divided between the region of Epirus in northwestern Greece and the counties of Gjirokastër, Vlorë, and Berat in southern Albania. The largest city in Epirus is Ioannina, seat of the region of Epirus, with Gjirokastër the largest city in the Albanian part of Epirus.

A rugged and mountainous region, Epirus lay on the periphery of the ancient Greek world. It was inhabited by the Greek tribes of the Chaonians, Molossians, and Thesprotians, and home to the sanctuary of Dodona, the oldest ancient Greek oracle, and the most prestigious one after Delphi. Unified into a single state in 370 BC by the Aeacidae dynasty, Epirus achieved fame during the reign of Pyrrhus I of Epirus, whose campaigns against Rome are the origin of the term "Pyrrhic victory". Epirus subsequently became part of the Roman Empire along with the rest of Greece in 146 BC, which was followed by the Byzantine Empire. Following the fall of Constantinople to the Fourth Crusade, Epirus became the center of the Despotate of Epirus, one of the successor states to the Byzantine Empire. Conquered by the Ottoman Empire in the 15th century, Epirus became semi-independent during the rule of Ali Pasha in the early 19th century, but the Ottomans re-asserted their control in 1821. Following the Balkan Wars and World War I, southern Epirus became part of Greece, while northern Epirus became part of the newly created state of Albania.