Lil is invited to a party with all of the popular kids from school, provided her brother does not come with her, as the kids believe he is “socially inept” and “hygienically challenged”. Lil begins to pull away from Phil, even though he tries to remain close to her. When Phil and Lil are partnered together for a science project, Lil freaks out and angrily reminds everyone that she and Phil are separate individuals and not a single person, much to Phil's embarrassment. When their parents, Betty and Howard, arrive home excited for their family vacation trip to 'Nick and Dick’s Twin Canyon Resort' Lil refuses to go. Betty, upset that Lil is unhappy, allows Lil to move into the family’s office/workout room to give her a space of her own. However, Phil struggles to deal with the changes and misses having Lil in his life, despite Dil’s attempts to become Phil’s new twin. When Lil goes to her party, her new friends begin to make fun of Phil, which makes Lil realise how close to her brother she really is and she leaves the party after telling off the popular kids. In the end, she agrees to go to ‘Twin’s Canyon’ with Phil.

After meeting a woman from a talent agency, Susie begins to believe that she has the talent needed to become an international pop star. The woman tells Susie that she has many perspective clients ready to meet her, provided she pays $1,000. Unable to come up with the money on her own or ask her parents for it, she turns to her older sister, Alisa, who has been saving up for a house. Alisa agrees to give her the money, however, when Susie arrives at the building she was told to meet at, she discovers it is deserted. Completely devastated, Susie goes home and tells her sister about the lost money. Alisa is understanding, but angry that Susie put her life at risk. Despite her setback, Susie goes onstage at Chas and Betty’s cafe, the Java Lava, for a talent night and is a huge success.

In Science class, while building grapefruit batteries, the school bad-boy, Z, explodes his causing bits to become lodged in Chuckie’s nose. When Chuckie has to go to the nurse, the teacher, Mr. Beaker, partners Kimi with Z for the experiment. Kimi hits it off with Z, whom she admires for being an individual. Chuckie, however, is horrified at the thought of Kimi hanging around with a “bad-boy”, however the rest of the gang encourage him not to judge a book by its cover. Chuckie is not convinced and encourages them to help him spy on Z. When they look in his locker, they find it full of electronics, which Chuckie believes to be stolen. Chuckie later skips class and follows Z to the arcade and records him telling a sketchy guy to meet him at the alley behind the warehouse on 10th. When Chuckie learns that Kimi plans on meeting Z that night, he lets her listen to the tape of Z’s mysterious plans. Kimi pretends to be heartbroken and goes into the bathroom, but sneaks out the window to meet him. When Chuckie and the boys arrive in the alley, Chuckie catches Z and Kimi entering a truck with a lot of merchandise. Scared for his sister, Chuckie swerves his bike in front of the truck causing it to stop. When he confronts Z he finds out that the merchandise is for charity to help raise money for inner-city schools and that the sketchy man is Z’s dad. Kimi is angry and says she will never forgive Chuckie, but Z encourages her to cut her friends and brother some slack since they only did what they did because they cared about her.

Tommy becomes excited when he learns about an upcoming film contest that is going to be judged by his favorite director, Martin Costomiris. His parents, Didi and Stu, encourage him to enter, but Tommy is unsure of what kind of movie he wants to make. Eventually he decides on a sci-fi thriller about aliens, staring his friends. However, he quickly becomes frustrated by his friends constant bickering and unprofessionalism. He realises that filming his friends’ secret conversations is more film worthy than his sci-fi thriller. When reviewing the footage, Dil tells Tommy he does not think that entering the footage about their friends’ secrets would be a very good idea. Angelica comes over one day demanding to see the tape when Tommy is not home. When Angelica sees the tapes she calls over the whole gang to watch it, who except for Chuckie and Dil, are all outraged that Tommy would consider entering their private moments into the competition. Tommy refuses to destroy the tape and his friends storm out and give Tommy the cold shoulder for the next couple of days. The film Tommy enters for the competition, A Day before the Day of the Life of My Friends, features bloopers from his earlier attempt at making a movie and clips of the gang as babies. Tommy did not win the competition but he got a picture of him with his favourite director and he got his friends back.

Chuckie has a crush Nicole Boscerelli, but he is afraid to talk to her because she does not notice his existence. Desperate, he goes to Kimi for help on changing his image to get Nicole to notice him. She agrees with the condition that Chuckie takes her shift at the Java Lava so she can go to a concert with Lil. With the confidence he receives from his new disguise he develops an alter ego as foreign exchange student, Chongo, when he introduces himself to her. Tommy tells Chuckie he does not need to become a different person to impress Nicole and that Nicole does not really like Chuckie but the fictional Chongo. Chuckie is convinced that he can keep the charade going. One afternoon when working at the Java Lava Nicole comes in for a smoothie and spends time talking about Chongo to Chuckie and tells him that she appreciates his great listening skills. With his success in talking to her Chuckie decides to tell Nicole that he is really Chongo, but when he arrives, Nicole insists that Chongo meet her new friend Chuck… from the Java Lava. Chuckie tries to keep switching between Chongo and himself but is caught by Nicole who is angry at him for lying to her but stills wants to be friends with him regardless.

There is a thief who has been stealing things from gardens, so Betty DeVille sets up a neighbourhood watch to catch the thief. Tommy and the gang think that the thief is Dil after Tommy finds Susie’s bike in their garage and the Deville’s garden gnome in Dil’s room. Dil keeps denying that he is the thief, so Tommy holds a sleepover inviting Chuckie, Phil and Lil to stay over and help him catch Dil. As well as catch Dil in the act Tommy, Phil and Lil are studying for the Standardised Test and are freaking out. It turns out that the thief was Tommy, but only because he was sleepwalking due to the amount of stress that he was under from studying for the Standardised Test.

Tommy wins the National Junior Director’s Chair Award for his short film, Kaleidoscope Lunch. However, Dil is saddened by Tommy’s success because he feels that he and Tommy are growing apart and that he will be forgotten when Tommy becomes famous. So he decides to spend as much time with Tommy as he possibly can, much to Tommy annoyance. Finally Tommy cracks and tells Dil that he is acting ridiculous and that nothing between them as brothers was going to change. Despite this, Dil cannot help but feel that he will eventually be forgotten, so he decides to begin preparing for a life without Tommy. He attempts to hang out with the other 4th grade kids, since he usually hangs out with Tommy and his friends, but they think that he’s too strange. Tommy begins to get groupies, who obsessively follow him around. When he is in the back room of the Java Lava with Chuckie they see that Dil is a guest on the new hit show, ‘What’s Your Tragedy?’ Tommy and Chuckie go to the studio and Tommy publicly apologizes for his behaviour. The conniving talk show host tries to convince Dil to dump Tommy and he almost does until Tommy drags him backstage to talk. Dil admits that he is ashamed of being different and that he fears losing Tommy being as Tommy is the only one who understands him. Tommy reminds Dil that it is the different people in the world that make the biggest difference in life. They leave the talk show and go to Tommy’s surprise party at the Java Lava.

Grandpa Lou chaperons Tommy's class field trip to the Human Body Museum. Tommy becomes embarrassed, because Grandpa Lou is quite slow as he is a lot older now than he used to be, so they do not get to do everything there is at the museum and he keeps telling old stories, which no ones finds interesting. Sean, his friend and Tommy sneak off and Sean makes them go to a part of the museum that is out of bounds. They get trapped and Grandpa Lou saves them in a way that reminds Tommy of some of the war stories that Grandpa Lou had told him. Tommy then forgives Grandpa Lou for embarrassing him.

There is a Valentine's Day dance. Dil makes friends with the new boy Lil’ Q, guest star Lil' Romeo, who is a hacky sacker, but his hacky sacky turns out to be cupid’s arrow. Chuckie is planning to ask Nicole to the dance, but while Dil is helping Lil Q with his hacky sacky aiming Lil’ Q goes to hit Nicole’s book, but he accidentally hits Nicole making her fall in love with Tommy. Chuckie gets angry with Tommy and they fall out. Angelica is scheming to get the boy of her dreams, Sean Butler, into asking her to the dance, but while she’s talking to him Nicole, Tommy and Chuckie are walking passed, so Lil’ Q tries to undo his mistake earlier, but this time instead of hitting Nicole with his hacky sacky he hits Sean on the head and he falls in love with Susie (who is sitting on a bench). Later at the Java Lava Angelica warns Kimi to keep Susie away from Z, because Susie is a boy stealer. Kimi tells Angelica that there is not anything to worry about because she, Susie and Z are just friends. Lil’ Q and Dil are practising throwing the hacky sacky around the Java Lava and when Lil’ Q throws it he hits Z who is carrying smoothies back to their table. He immediately falls in love with Susie and he and Sean argue over who is taking Susie to the dance and Kimi gets upset because she likes Z.

An older girl, Francine, publicly humiliates Tommy. At first he does not know why, but then Lil and Kimi convince Tommy that Francine has a crush on him. When he finds out that Francine did not have a crush on him, she humiliates him even more. In the end it becomes apparent that she was only humiliating him because he had cut her scene in one of his films. Once they discuss the misunderstanding they become friends.

On being given a family tree project Chuckie and Kimi are excited that they only have one piece of homework between them as they are brother and sister. However Kimi discovers her Japanese heritage and decides that she and Chuckie should work on separate projects, because she is studying all of her biological family’s side, not her half father’s side (Chuckie’s dad). At first Chuckie is supportive of his sister, but after she drags the Finster family into a charade for the schools culture festival, which humiliates them, Chuckie becomes annoyed and wants his old sister back.

Angelica has been invited to one of Savannah's parties, and must find a dress that she has not already worn. While working at the hospital she trips and breaks her nose. Not wanting to be seen by anyone, because she has a cast on her nose she fakes having a crazy illness after seeing it on a drama on the hospital television. She then meets a small boy in the hospital, who has greater problems than herself and sees that she is being selfish by pretending to be ill so that she can stay in the hospital and not be seen by Savannah and her friends.

Susie is forced to choose between singing at the TV Talent Show, and leading her language team to victory in the language bowl, which is held on the same day.

Tommy’s school have a Science fair and Tommy has an idea to create a machine that can sort socks by colour so that you never end out wearing odd socks. After asking his dad, Stu, for a little advice Stu becomes a little too helpful and takes over. Stu takes over so much that Tommy has to admit that the project is no longer his design at the prize giving event.

As the holiday season approaches, Chuckie is dreading another forgettable Christmas. In order to liven things up, he mistakenly steals a great tree (to replace the lame one his dad has picked out). When he discovers that the whole community is after the thief, he hatches a plan to rectify the situation.

Angelica tries to help Chuckie become more popular for a school project, but it backfires when he takes her advice, and he becomes more popular than her.

It's soccer season, and as per usual, Phil has soccer on the brain. But when Lil casually joins the team, she surprises everyone, including herself, by instantly becoming a super star.

Susie thinks that Angelica does not think much about the future. While Angelica worries about getting a navel piercing, Susie tries to get a scholarship to a good college. The girls are on a school trip and get lost and Susie loses her laptop with all of her work on that she needs to show to a college.

Susie trains Harold to help him get a date with Angelica. He soon becomes the most wanted boy in school.

Angelica falls for Darryl, but she gets too nervous to talk to him whenever he's around. Her mom loses her CEO job and decides to become a full-time mom. Then, they get stranded together on a sail boat on the same day as Darryl's rock concert.