The Organización Nacional Estudiantil de Futbol Americano (English: National Student Organization of American Football), usually known by the acronym ONEFA, is the major college football league in Mexico.

American football had been played in Mexico since the early 1920s in different colleges and universities, mainly in Mexico City. In 1928 the first professional championship was played, organized by Jorge Braniff. From the 1920s to the 1970s more universities and colleges joined the championship, and four categories, called fuerzas were created. The First Fuerza became the National League in 1970, and in 1978 it was reorganized under the name ONEFA.

The universities that originally participated in the ONEFA were Universidad Autónoma de Nuevo León, Universidad Autónoma de Chapingo, Instituto Politécnico Nacional, Universidad Autónoma de Coahuila, Universidad Autónoma de Chihuahua and Universidad Autónoma Agraria Antonio Narro.

Today the ONEFA is divided into three categories: Liga Mayor, Liga Intermedia and Liga Juvenil. The most important one is the Liga Mayor (Major League), whose championships are organized into three conferences: the North Conference, the Central Conference, and the Southern Conference.