Predatory fish are fish that predate upon other fish or animals. Some predatory fish include perch, muskie (muskellunge), pike, walleye, and salmon.

Levels of large predatory fish in the global oceans are estimated to be about 10% of their pre-industrial levels. Large predatory fish are most at risk of extinction; there was a disproportionate level of large predatory fish extinctions during the Cretaceous–Paleogene extinction event 65 million years ago. Creation of marine reserves has been found to restore the population of large predatory fish as the Serranidae — groupers and sea bass.

Predatory fish switch between types of prey in response to variations in their abundance. Such changes in preference are disproportionate and are selected for as evolutionarily efficient.

Predatory fish may become a pest if they are introduced into an ecosystem in which they become a new top predator. An example, which has caused such trouble in Maryland, is the snakehead fish.

Predatory fish such as sharks and tuna form a part of the human diet, but they may concentrate significant quantities of mercury in their bodies if they are apex predators, due to bioaccumulation.