Cayce may refer to:

Edgar Cayce (/ˈkeɪsiː/; March 18, 1877 – January 3, 1945) was an American psychic who allegedly had the ability to give answers to questions on subjects such as healing or Atlantis while in a hypnotic trance. Though Cayce himself was a devout Christian and lived before the emergence of the New Age Movement, some believe he was the founder of the movement and influenced its teachings.

Cayce became a celebrity toward the end of his life and the publicity given to his prophecies has overshadowed what to him were usually considered the more important parts of his work, such as healing (the vast majority of his readings were given for people who were sick) and theology (Cayce was a lifelong, devout member of the Disciples of Christ). Skeptics challenge the statement that Cayce demonstrated psychic abilities, and traditional Christians also question his unorthodox answers on religious matters (such as reincarnation and Akashic records, although others accept his abilities as "God-given").

Cayce founded a nonprofit organization, the Association for Research and Enlightenment.