Sertraline hydrochloride (trademark names Zoloft and Lustral) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It was introduced to the market by Pfizer in 1991. Sertraline is primarily used to treat major depression in adult outpatients as well as obsessive–compulsive, panic, and social anxiety disorders in both adults and children. In 2007, it was the most prescribed antidepressant on the U.S. retail market, with 29,652,000 prescriptions.

The efficacy of sertraline for depression is similar to that of older tricyclic antidepressants, but its side effects are much less pronounced. Differences with newer antidepressants are subtler and also mostly confined to side effects. Evidence suggests that sertraline may work better than fluoxetine (Prozac) for some subtypes of depression. Sertraline is highly effective for the treatment of panic disorder, but cognitive behavioral therapy in combination with sertraline is a better treatment for obsessive-compulsive disorder than sertraline alone. Although approved for social phobia and posttraumatic stress disorder, sertraline leads to only modest improvement in these conditions. Sertraline also alleviates the symptoms of premenstrual dysphoric disorder and can be used in sub-therapeutic doses or intermittently for its treatment.

The word asshole, a variant of arsehole, which is still prevalent in British and Australian English, is a vulgar to describe the anus, often pejoratively used to refer to people.

The word arse in English derives from the Germanic root *arsaz, which originated from the Proto-Indo-European root *ors — meaning buttocks or backside. The combined form arsehole is first attested from 1500 in its literal use to refer to the anus. The metaphorical use of the word to refer to the worst place in a region, e.g., "the arsehole of the world") is first attested in print in 1865; the use to refer to a contemptible person is first attested in 1933. In the ninth chapter of his 1945 autobiography, Black Boy, Richard Wright quotes a snippet of verse that uses the term: "All these white folks dressed so fine / Their ass-holes smell just like mine ...". Its first appearance as an insult term in a newspaper indexed by Google News is in 1965. As with other vulgarities, these uses of the word may have been common in oral speech for some time before their first print appearances. By the 1970s, Hustler magazine featured people they did not like as "Asshole of the Month." In 1972, Jonathan Richman's Modern Lovers recorded his song "Pablo Picasso," which includes the line "Pablo Picasso was never called an asshole."