HER2 (Human Epidermal Growth Factor Receptor 2) also known as Neu, ErbB-2, CD340 (cluster of differentiation 340) or p185 is a protein that in humans is encoded by the ERBB2 gene. HER2 is a member of the epidermal growth factor receptor (EGFR/ErbB) family. Amplification or over-expression of this gene has been shown to play an important role in the pathogenesis and progression of certain aggressive types of breast cancer and in recent years it has evolved to become an important biomarker and target of therapy for the disease.
HER2 is encoded by ERBB2, a known proto-oncogene located at the long arm of human chromosome 17(17q21-q22). HER2 is named because it has a similar structure to human epidermal growth factor receptor, or HER1. Neu is so named because it was derived from a rodent glioblastoma cell line, a type of neural tumor. ErbB-2 was named for its similarity to ERBB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR. Gene cloning showed that HER2, Neu, and ErbB-2 are all encoded by the same gene.
David A. Jaffray PhD is a Canadian medical physicist and Senior Scientist in the Division of Biophysics and Bioimaging at the Ontario Cancer Institute. He is also a professor and Vice Chair in the University of Toronto's Department of Radiation Oncology. He is the inventor, together with John Wong, of on-line volumetric kv-imaging guidance system for radiation therapy[citation needed].
Jaffray's work focuses on the development of novel imaging systems and concepts to improve the precision of therapy by generating images at the time of therapy for the purpose of guiding the treatment delivery. Recent developments have included the construction of megavoltag] and kilovoltage imaging systems based upon high-performance charged coupled device cameras, prototyping, and evaluation of amorphous-silicon based large-area detectors for megavoltage work[citation needed].
In addition, a kilovoltage cone-beam computed tomography (CT) system has been developed. These systems have been integrated with the megavoltage treatment devices to improve the precision with which the therapy could be executed without the interference of mechanical immobilization systems. The cone-beam CT approach has also been extended to a mobile C-arm for intra-operative imaging and therapy guidance.
Hello
What would you like to know?
What would you like to hear?
What if I just disappear inside myself?
Hello
What would you like to know?
Who would you like to see?
Who would you like me to be, if not myself?
And the Europop
Makes me dizzy
And I just can't stop
'Til it's finished
And I don't know what
You find funny 'bout the Europop
And the love of money
Hello
Where is it cool to go?
When is it cool to leave?
What is it cool to breathe inside myself?
Hello
Don't tell me what I already know
Don't show me what I've already seen
Don't take me where I've already been
Inside myself
And the Europop
Makes me dizzy
And I just can't stop
'Til it's finished
And I don't know what
You find funny 'bout the Europop
And the love of money
Financial gain
Is a very pleasant thing
But the transitory pleasure that it brings
Counts for nothing!
What is there left to know?
What is there left to say?
Nothing
And the Europop
Makes me dizzy
And I just can't stop
'Til it's finished
And I don't know what
You find funny 'bout the Europop
And the love of money
And I thank God
That you're aware
Oh thank God
That you're aware
Of the earth and of the air
And of the girls making like they don't care
But they are blessed
And you are cursed
With the conscience of a universe
Of the mind and of the soul
Of reduction science digging itself a hole
And I thank God that you're aware
And thank your God we're all aware
It's taken time but I'll think you'll find
Hello
What would you like to know?
What would you like to hear?
What if I just disappear inside myself?
Hello
What would you like to know?
Who would you like to see?
Who would you like me to be if not myself?
And the Europop (pop) makes me dizzy
And I just can't stop (stop) 'til it's finished
And I don't know what (what) you find funny
'Bout the Europop and the love of money
Hello
Where is it cool to go?
When is it cool to leave?
What is it cool to breathe inside myself?
Hello
Don't tell me what I already know
Don't show me what I've already seen
Don't take me where I've already been inside myselfFinancial gain is a very pleasant thing
The transitory pleasure that it brings
Counts for nothing
So
What is there left to know?
What is there left to say?
Nothing
And I thank God that you're aware
Oh thank God that you're aware
Of the earth and of the air
And of the girls making like they don't care
That they are blessed and you are cursed
With the conscience of the universe
Of the mind and of the soul
And reduction science digging itself a hole
And I thank God that you're aware
Oh thank God that you're aware
It's taken time but I think you'll find
That everything is alright
Europop
Europop
Europop
Europop
It's a musical kink coming from our roots
And we play it loud cause it's groovy with a style
It's a cultural thing from all country wide
It's a musical flag and we call it Europop
Always Europop, Europop, Europop
From the TV sets to the radio
You can feel the force of the music in the night
All through Amsterdam straight to Italy
You can feel the beat of a european thing
Always Europop, Europop, Europop, Europop, Europop
All through Amsterdam straight to Italy
You can feel the beat of a european thing
All through Amsterdam straight to Italy
You can feel the beat of a european thing
I approach gold that's gleaming
'Its about time' - they've warned me
I've been so apathetic
... but now I'm a hungry addict
Yeah
Oh...
Don't call us
We will call you
Don't love us
We will love you
Don't need us
We will need you!
When the times right
We'll feed you
He's suffered and we know it
Nobody comes to visit
They all agree he's genius
But they've got lives to lead
Things to do!
Places to go!
Don't call us
Etc...
He's down
It's read in his eyes
But so what?!
It's tough all over
His dreamgirl is a butterfly
He's killable
Constantly die
Don't call us
We will call you!
Don't love us
We will love you!
Don't need us!
We will need You
When the times right,...