Mohandessin (Arabic: المهندسين‎), could also be spelled Mohandesin or Mohandeseen, is an up-scale neighborhood in Giza. Its name means in Arab literally the engineers, which was because it was given to at cheaper prices to engineers in Egypt; there is a similar area in Mohandesin called Sahafeyeen (journalists), mo'alemeen (Teachers), and ateba'a (Doctors), all designed for people with these professions.

Mohandessin was built in the early 1950s. It was built over agriculture land and was a massive area of villas, and mansions. However in the 1970s, the population increased dramatically, and the once the rich villas neighborhood turned into crowded apartment blocks. In the last 10 years, Mohandessin became the most expensive districts to in real estates. Apartments have a cost of about EGP 12,000 (USD 2000) per square meter.

Today, Mohandessin is usually referred to the districts of Dokki, Agouza and Mohandessin.

A major street that is intersecting the neighborhood called Game'et el Duwal el Arabya (Arab League Blvd.). The main shopping area in Mohandesin is called Sour Nadi el Zamalik, which is a magnetic location for Arab Tourists that visit Cairo in the summer and on vacations. Also a new state of the art mall in Shehab street was constructed and currently operating, it is called Platinum Mall. Several sporting clubs are also to found there, including Tersana , El Zamalek, and The Shooting Club.