John A. DeFrancisco (born October 16, 1946) represents District 50 in the New York State Senate, which comprises Skaneateles, Pompey, Van Buren, most of Onondaga County and the western half of Syracuse, among other communities located in Upstate New York. He is a Republican.

First elected in 1992, DeFrancisco previously spent eleven years on the Syracuse Common Council as both a Councilor-at-large and then the Council President. He has also served in the past as the President of the Syracuse City School District Board of Education and the Vice-President of the Conference of Large City Boards of Education. He was also an associate with the law firm of Simpson, Thatcher and Bartlett, served as a Judge Advocate in the United States Air Force and was the Assistant District Attorney in Onondaga County from 1975 until 1977.

Some of his accomplishments while in the State Senate include serving as an advocate for the enactment of Jenna's Law and promoting the emendation of the Rockefeller drug laws.