Dhe

Ze with descender (Ҙ ҙ; italics: Ҙ ҙ) is a letter of the Cyrillic script. It is used in the Bashkir language where it represents the voiced dental fricative /ð/, like the pronunciation of ⟨th⟩ in "this".

Computing codes

See also

Dihydroergotamine

Dihydroergotamine (/daɪˌhaɪdroʊ.ɜːrˈɡɒtəmiːn/ dy-HY-droh-ur-GOT-ə-meen; brand names D.H.E. 45 and Migranal) is an ergot alkaloid used to treat migraines. It is a derivative of ergotamine. It is administered as a nasal spray or injection and has an efficacy similar to that of sumatriptan. Nausea is a common side effect.

It has similar actions to the triptans, acting as an agonist to the serotonin 5-HT(1D) receptors and causing vasoconstriction of the intracranial blood vessels, but also interacts centrally with dopamine and adrenergic receptors. It can be used to treat acute intractable headache or withdrawal from analgesics.

Description

Dihydroergotamine (DHE) is a semi-synthetic form of ergotamine approved in the US in 1946. Oral bioavailability is poor and it is not available in oral form in the US. DHE is available as Migranal nasal spray and in ampules for subcutaneous, intramuscular and intravenous injection. Efficacy is variable in the nasal spray form with bioavailability 32% of injectable administration. Subcutaneous and intramuscular injections are generally more effective than the nasal spray and can be self-administered by patients. Intravenous injection is considered very effective for severe migraine or status migrainosus. DHE is also used in the treatment of medication overuse headache.
Nausea is a common side effect of IV administration and less common in other modes. Antiemetics can be given prior to DHE to counteract the nausea. Risks and contraindications are similar to the triptans. DHE and triptans should not be taken within 24 hours of each other due to the potential for coronary artery vasospasm. DHE produces no dependence.
MAP Pharmaceuticals submitted an inhaled version of DHE (Levadex) for FDA approval in May 2011. Allergan acquired the rights to the product, now known as Semprana, for nearly $1 billion but the FDA has rejected it 3 times due to quality control issues and it has yet to gain approval.

Saints Cyril and Methodius

Saints Cyril and Methodius (826-869, 815-885; Greek: Κύριλλος καὶ Μεθόδιος; Old Church Slavonic: Кѷриллъ и Меѳодїи) were two Byzantine Christian theologians and Christian missionaries who were brothers. Through their work they influenced the cultural development of all Slavs, for which they received the title "Apostles to the Slavs". They are credited with devising the Glagolitic alphabet, the first alphabet used to transcribe Old Church Slavonic. After their deaths, their pupils continued their missionary work among other Slavs. Both brothers are venerated in the Orthodox Church as saints with the title of "equal-to-apostles". In 1880, Pope Leo XIII introduced their feast into the calendar of the Roman Catholic Church. In 1980, Pope John Paul II declared them co-patron saints of Europe, together with Benedict of Nursia.

Early career

Early life

The two brothers were born in Thessalonica, in present-day Greece – Cyril lived from 827–828 and Methodius 815–820. Cyril was reputedly the youngest of seven brothers; he was born Constantine, but took the name Cyril upon becoming a monk in Rome shortly before his death, according to the "Vita Cyrilli" ("The Life of Cyril"). Methodius was born Michael and took the name Methodius upon becoming a monk at Mysian Olympus (present-day Uludağ), in northwest Turkey. Their father was Leo, a droungarios of the Byzantine theme of Thessalonica, and their mother was Maria.

Cyrillic script

The Cyrillic script /sᵻˈrɪlɪk/ is an alphabetic writing system employed across Eastern Europe and north and central Asia. It is based on the Early Cyrillic, which was developed during the First Bulgarian Empire in the 9th century AD at the Preslav Literary School. It is the basis of alphabets used in various languages, past and present, in parts of Southeastern Europe and Northern Eurasia, especially those of Slavic origin, and non-Slavic languages influenced by Russian. As of 2011, around 252 million people in Eurasia use it as the official alphabet for their national languages, with Russia accounting for about half of them. Cyrillic is one of the most used writing systems in the world.

Cyrillic is derived from the Greek uncial script, augmented by letters from the older Glagolitic alphabet, including some ligatures. These additional letters were used for Old Church Slavonic sounds not found in Greek. The script is named in honor of the two Byzantine brothers,Saints Cyril and Methodius, who created the Glagolitic alphabet earlier on. Modern scholars believe that Cyrillic was developed and formalized by early disciples of Cyril and Methodius of Bulgarian origin, most notable of which was Clement of Ohrid.

Cyrillic (disambiguation)

Cyrillic refers to the Cyrillic script. It may also refer to: