Uasin Gishu District is one of the seventy-one districts of Kenya, located in the Rift Valley Province. The city of Eldoret is its capital, administrative center and commercial center.

The Uasin Gishu District has a cool and temperate climate and is located on a plateau. It borders the Trans-Nzoia District.

In 1908, fifty eight families of Afrikaans-speaking South Africans settlers "trekked" to the Uashin Gishu plateau from Nakuru after a journey from South Africa by sea and by rail from Mombasa. They were followed by sixty more families in 1911 and more later. The town of Eldoret was established in the midst of the farms they created.

There is a large population of immigrants from England, Scotland, South Africa and Zimbabwe, who have come to settle and farm.

In 1903 Theodor Herzl negotiated with British officials to obtain land for a permanent Jewish settlement. The British government eventually offered up the Uasin Gishu plateau, which at the time was part of British East Africa. The British plan for Jewish settlement in this area was eventually aborted.