Girl, Interrupted is a best-selling1993 memoir by American author Susanna Kaysen, relating her experiences as a young woman in a psychiatric hospital in the 1960s after being diagnosed with borderline personality disorder. The memoir's title is a reference to the Vermeer painting Girl Interrupted at her Music.

While writing the novel Far Afield, Kaysen began to recall her almost two years at McLean Hospital. She obtained her file from the hospital with the help of a lawyer.

In 1999, the memoir was adapted into a film of the same name starring Winona Ryder and Angelina Jolie. It was directed by James Mangold.

The plot of Girl, Interrupted does not follow a linear storyline, but instead the author provides personal stories through a series of non-chronological vignettes and personal reflections on why she was institutionalized.

In April 1967, 18-year-old Susanna Kaysen is admitted to McLean Hospital, in Belmont, Massachusetts, after attempting suicide. She denies that it was a suicide attempt to a psychiatrist, who suggests she take time to regroup in McLean, a private mental hospital. Susanna is diagnosed with borderline personality disorder, and her stay extends to 18 months.

Angelina Jolie ( /dʒoʊˈliː/ joh-LEE, born Angelina Jolie Voight; June 4, 1975) is an American actress and director. She has received an Academy Award, two Screen Actors Guild Awards, and three Golden Globe Awards, and was named Hollywood's highest-paid actress by Forbes in 2009 and 2011. Jolie promotes humanitarian causes, and is noted for her work with refugees as a Special Envoy and former Goodwill Ambassador for the United Nations High Commissioner for Refugees (UNHCR). She has been cited as the world's "most beautiful" woman, a title for which she has received substantial media attention.

Jolie made her screen debut as a child alongside her father Jon Voight in Lookin' to Get Out (1982), but her film career began in earnest a decade later with the low-budget production Cyborg 2 (1993). Her first leading role in a major film was in the cyber-thriller Hackers (1995). She starred in the critically acclaimed biographical television films George Wallace (1997) and Gia (1998), and won an Academy Award for Best Supporting Actress for her performance in the drama Girl, Interrupted (1999).

Brittany Anne Murphy-Monjack (November 10, 1977 – December 20, 2009), known professionally as Brittany Murphy, was an American actress and singer. She starred in films such as Clueless, Just Married, Girl Interrupted, Spun, 8 Mile, Uptown Girls, Sin City, Happy Feet, and Riding in Cars with Boys. She voiced Luanne Platter on the animated TV series King of the Hill. Her final film, Something Wicked, was released on August 25, 2011.

Brittany Murphy was born as Brittany Anne Bertolotti in Atlanta, Georgia, on November 10, 1977. Her parents, Sharon Kathleen Murphy and Angelo Joseph Bertolotti, divorced when she was two years old, and Murphy was raised by her mother in Edison, New Jersey, where she attended Edison High School. Bertolotti was so estranged from the family that he was not named as the father on the first death certificate. The family later moved to Los Angeles so that Murphy could pursue an acting career. Murphy said her mother never tried to stifle her creativity, and she considered her mother a crucial factor in her later success: "When I asked my mom to move to California, she sold everything and moved out here for me. ... She always believed in me." Murphy's mother is of Irish and Eastern European descent and her father is Italian American. She was raised a Baptist and later became a non-denominational Christian. She had two older half-brothers and a younger half-sister.

Jared Joseph Leto (born December 26, 1971) is an American actor, director, producer, musician, and occasional model. Leto has appeared in both big budget Hollywood films and smaller projects from independent producers and art houses. He rose to prominence for playing Jordan Catalano in the teenage drama My So-Called Life (1994). He later made his film debut in How to Make an American Quilt (1995) and received first notable critical praise for his performance in Prefontaine (1997). Leto played supporting roles in The Thin Red Line (1998) and Girl, Interrupted (1999), as well as the lead role in the horror film Urban Legend (1998), and earned critical acclaim after portraying heroin addict Harry Goldfarb in Darren Aronofsky's Requiem for a Dream (2000). He has worked with director David Fincher in Fight Club (1999) and Panic Room (2002). Since the 2000s, Leto has been nominated for awards for his work in such films as American Psycho (2000), Highway (2002), Lord of War (2005), Lonely Hearts (2006), Chapter 27 (2007), and Mr. Nobody (2009).

Winona Ryder (born Winona Laura Horowitz; October 29, 1971) is an American actress. She made her film debut in the 1986 film Lucas. Ryder's first significant role came in Tim Burton's Beetlejuice (1988) as Lydia Deetz, a goth teenager, which won her critical and commercial recognition. After various appearances in film and television, Ryder continued her career with the cult film Heathers (1989), a controversial satire of teenage suicide and high school life, which drew Ryder further critical and commercial attention.

Having played diverse roles in many well-received films, Ryder won a Golden Globe Award for Best Supporting Actress and an Academy Award nomination in the same category for her role in The Age of Innocence in 1993, as well as another Academy Award nomination for Little Women the following year for Best Actress. In 2000, Ryder received a star on the Walk of Fame in Hollywood, California.

Ryder's personal life has been widely reported by the media. Her relationship with actor Johnny Depp in the early 1990s was highly publicized and received much scrutiny by the media and tabloid press. A much talked-about 2001 shoplifting incident led to a four-year hiatus from acting. She has also revealed her personal struggle with anxiety and depression, briefly checking into a clinic.