The skull and crossbones is a common symbol for toxicity.

Toxicity is the degree to which a substance can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or an organ such as the liver (hepatotoxicity). By extension, the word may be metaphorically used to describe toxic effects on larger and more complex groups, such as the family unit or society at large.

A central concept of toxicology is that effects are dose-dependent; even water can lead to water intoxication when taken in too many doses, whereas for even a very toxic substance such as snake venom there is a dose below which there is no detectable toxic effect. Toxicity is species-specific, lending cross-species analysis problematic. Newer paradigms and metrics are evolving to bypass animal testing, while maintaining the concept of toxicity endpoints. ^[1]

Types of toxicity[link]

There are generally three types of toxic entities; chemical, biological, and physical:

• Chemical toxicants include inorganic substances such as lead, mercury, asbestos, hydrofluoric acid, and chlorine gas, organic compounds such as methyl alcohol, most medications, and poisons from living things.
• Biological toxicants include bacteria and viruses that can induce disease in living organisms. Biological toxicity can be difficult to measure because the "threshold dose" may be a single organism. Theoretically one virus, bacterium or worm can reproduce to cause a serious infection. However, in a host with an intact immune system the inherent toxicity of the organism is balanced by the host's ability to fight back; the effective toxicity is then a combination of both parts of the relationship. A similar situation is also present with other types of toxic agents.
• Physical toxicants are substances that, due to their physical nature, interfere with biological processes. Examples include coal dust and asbestos fibers, both of which can ultimately be fatal if inhaled.

Measuring toxicity[link]

Toxicity can be measured by its effects on the target (organism, organ, tissue or cell). Because, individuals typically have different levels of response to the same dose of a toxin, a population-level measure of toxicity is often used which relates the probabilities of an outcome for a given individual in a population. One such measure is the LD₅₀. When such data does not exist, estimates are made by comparison to known similar toxic things, or to similar exposures in similar organisms. Then, "safety factors" are added to account for uncertainties in data and evaluation processes. For example, if a dose of toxin is safe for a laboratory rat, one might assume that one tenth that dose would be safe for a human, allowing a safety factor of 10 to allow for interspecies differences between two mammals; if the data are from fish, one might use a factor of 100 to account for the greater difference between two chordate classes (fish and mammals). Similarly, an extra protection factor may be used for individuals believed to be more susceptible to toxic effects such as in pregnancy or with certain diseases. Or, a newly synthesized and previously unstudied chemical that is believed to be very similar in effect to another compound could be assigned an additional protection factor of 10 to account for possible differences in effects that are probably much smaller. Obviously, this approach is very approximate; but such protection factors are deliberately very conservative, and the method has been found to be useful in a deep variety of applications.

Assessing all aspects of the toxicity of cancer-causing agents involves additional issues, since it is not certain if there is a minimal effective dose for carcinogens, or whether the risk is just too small to see. In addition, it is possible that a single cell transformed into a cancer cell is all it takes to develop the full effect (the "one hit" theory).

It is more difficult to determine the toxicity of chemical mixtures than a pure chemical, because each component displays its own toxicity, and components may interact to produce enhanced or diminished effects. Common mixtures include gasoline, cigarette smoke, and industrial waste. Even more complex are situations with more than one type of toxic entity, such as the discharge from a malfunctioning sewage treatment plant, with both chemical and biological agents.

Global classifications of toxicity[link]

For substances to be regulated and handled appropriately they must be properly classified and labelled. Classification is determined by approved testing measures or calculations and have determined cut off levels set by governments and scientists. While currently many countries have different regulations regarding the types of tests, amounts of tests and cut off levels, the implementation of Global Harmonization will begin unifying these countries as early as 2008.^[2][3]

Global Classification looks at three areas: Physical Hazards (explosions and pyrotechnics),^[4] Health Hazards^[5] and Environmental Hazards.^[6]

Health hazards[link]

The types of toxicities where substances may cause lethality to the entire body, lethality to specific organs, major/minor damage, or cause cancer. These are globally accepted definitions of what toxicity is.^[5] Anything falling outside of the definition cannot be classified as that type of toxicant.

Acute toxicity[link]

Acute toxicity looks at lethal effects following oral, dermal or inhalation exposure. It is split into five categories of severity where Category 1 requires the least amount of exposure to be lethal and Category 5 requires the most exposure to be lethal. The table below shows the upper limits for each category.

Note: The undefined values are expected to be roughly equivalent to the category 5 values for oral and dermal administration.^{[citation needed]}

Other methods of exposure and severity[link]

Skin corrosion and irritation are determined though a skin patch test analysis. This examines the severity of the damage done; when it is incurred and how long it remains; whether it is reversible and how many test subjects were affected.

Skin corrosion from a substance must penetrate through the epidermis into the dermis within four hours of application and must not reverse the damage within 14 days. Skin irritation shows damage less severe than corrosion if: the damage occurs within 72 hours of application; or for three consecutive days after application within a 14 day period; or causes inflammation which lasts for 14 days in two test subjects. Mild skin irritation minor damage (less severe than irritation) within 72 hours of application or for three consecutive days after application.

Serious eye damage involves tissue damage or degradation of vision which does not fully reverse in 21 days. Eye irritation involves changes to the eye which do fully reverse within 21 days.

Other categories of toxicity[link]

• Respiratory sensitizers cause breathing hypersensitivity when the substance is inhaled.
• A substance which is a skin sensitizer causes an allergic response from a dermal application.
• Carcinogens induce cancer, or increase the likelihood of cancer occurring.
• Reproductively toxic substances cause adverse effects in either sexual function or fertility to either a parent or the offspring.
• Specific-target organ toxins damage only specific organs.
• Aspiration hazards are solids or liquids which can cause damage through inhalation.

Environmental hazards[link]

This section requires expansion.

Environmental hazards tend to focus on degradability, bioaccumulation and aquatic toxicity.^[6]

Mapping environmental hazards[link]

There are many environmental health mapping tools. TOXMAP is a Geographic Information System (GIS) from the Division of Specialized Information Services^[7] of the United States National Library of Medicine (NLM) that uses maps of the United States to help users visually explore data from the United States Environmental Protection Agency's (EPA) Toxics Release Inventory and Superfund programs. TOXMAP is a resource funded by the US Federal Government. TOXMAP's chemical and environmental health information is taken from NLM's Toxicology Data Network (TOXNET)^[8] and PubMed, and from other authoritative sources.

Aquatic toxicity[link]

Aquatic toxicity testing submerges key indicator species of fish or crustacea to certain concentrations of a substance in their environment to determine the lethality level. Fish are exposed for 96 hours while crustacea are exposed for 48 hours. While GHS does not define toxicity past 100 mg/l, the EPA currently lists aquatic toxicity as “practically non-toxic” in concentrations greater than 100 ppm.^[9]

Note: A category 4 is established for chronic exposure, but simply contains any toxic substance which is mostly insoluble, or has no data for acute toxicity.

Factors influencing toxicity[link]

Toxicity of a substance can be affected by many different factors, such as the pathway of administration (whether the toxin is applied to the skin, ingested, inhaled, injected), the time of exposure (a brief encounter or long term), the number of exposures (a single dose or multiple doses over time), the physical form of the toxin (solid, liquid, gas), the genetic makeup of an individual, an individual's overall health, and many others. Several of the terms used to describe these factors have been included here.

acute exposure

a single exposure to a toxic substance which may result in severe biological harm or death; acute exposures are usually characterized as lasting no longer than a day.

chronic exposure

continuous exposure to a toxin over an extended period of time, often measured in months or years; it can cause irreversible side effects.

Etymology[link]

Look up toxicity in Wiktionary, the free dictionary.

"Toxic" and similar words came from Greek τοξον = "bow (weapon)" via "poisoned arrow", which came to be used for "poison" in scientific language, as the usual Classical Greek word ('ιον) for "poison" would transcribe as "io-", which is not distinctive enough. In some biological names, "toxo-" still means "bow", as in Toxodon = "bow-toothed" from the shape.

See also[link]

References[link]

External links[link]

• Agency for Toxic Substances and Disease Registry
• Chemical and Other Safety Information – Oxford University
• Whole Effluent, Aquatic Toxicity Testing FAQ
• TOXMAP Environmental Health e-Maps from the United States National Library of Medicine
• Toxseek: meta-search engine in toxicology and environmental health

Britney Spears
Spears performing at her Femme Fatale Tour in Europe, 2011
Background information
Birth name	Britney Jean Spears
Born	(1981-12-02) December 2, 1981 (age 30) McComb, Mississippi, U.S.
Genres	Pop, dance
Occupations	Singer, songwriter, dancer, actress, record producer, author, fashion designer, video director
Instruments	Vocals, piano
Years active	1992–present
Labels	Jive, RCA[1]
Associated acts	The New Mickey Mouse Club
Website	britneyspears.com britney.com

Britney Jean Spears (born December 2, 1981) is an American recording artist and entertainer. Born in McComb, Mississippi, and raised in Kentwood, Louisiana, Spears began performing as a child, landing acting roles in stage productions and television shows. She signed with Jive Records in 1997 and released her debut album ...Baby One More Time in 1999, which became the best-selling album by a teenage solo artist.^[2] During her first decade in the music industry, she became a prominent figure in mainstream popular music and popular culture, followed by a much-publicized personal life. Her first two albums established her as a pop icon and broke sales records, while title tracks "...Baby One More Time" and "Oops!... I Did It Again" became international number-one hits. Spears was credited with influencing the revival of teen pop during the late 1990s, and became the 'best-selling teen aged artist of all time' before she turned 20,^[3] garnering her the honorific title of "Princess of Pop".^[4]

In 2001, she released her third studio album Britney and expanded her brand, playing the starring role in the film Crossroads. She assumed creative control of her fourth studio album, In the Zone (2003), which yielded chart-topping singles "Me Against the Music", "Toxic" and "Everytime". After the release of two compilation albums, Spears experienced personal struggles and her career went into hiatus. Her fifth studio album, Blackout, was released in 2007 and despite receiving little promotion, it spawned hits "Gimme More" and "Piece of Me". In 2008, her erratic behavior and hospitalizations caused her to be placed in a conservatorship. The same year, her sixth studio album Circus was released, with the global chart-topping lead single "Womanizer", and hits such as "Circus" and "If U Seek Amy". She embarked on her highest-grossing global concert tour,^[5] The Circus Starring Britney Spears, in 2009. In October of the same year, she released a chart-topping single, "3", which became her third single to reach number one on the Billboard Hot 100. Her seventh studio album Femme Fatale, released in 2011, has become the first of her albums to yield three top ten singles in the United States, "Hold It Against Me", "Till the World Ends" and "I Wanna Go". The same year, she also gained her fifth number one single when she featured on the remix of "S&M" alongside Rihanna.

Spears work has earned her numerous awards and accolades, including a Grammy Award, 6 MTV Video Music Awards including the Lifetime Achievement Award, 9 Billboard Music Awards, and a star on the Hollywood Walk of Fame. In 2009, Billboard ranked her as the 8th overall Artist of the Decade,^[6] and also recognized her as the best-selling female artist of the first decade of the 21st century, as well as the fifth overall.^[7] The Recording Industry Association of America (RIAA) also recognized Spears as the eighth top-selling female artist in the United States, with 33 million certified albums.^[8] Nielsen SoundScan ranked Spears the tenth best-selling digital artist of the country, with more than 28.6 million digital singles as of January 2012.^[9] She has sold over 100 million albums worldwide, making her one of the best-selling music artists of all time.^[10] Rolling Stone recognized her instant success as one of the Top 25 Teen Idol Breakout Moments of all time,^[11] while VH1 ranked her eleventh on their "100 Greatest Women in Music" list in 2012.^[12] Forbes also revealed that Spears was the sixth most powerful celebrity, and the third best paid musician of 2011-12, having topped the list back in 2002.^[13] In Fall 2012, Spears will serve as a judge in the second season of the American version of The X Factor.^[14]

Biography[link]

1981–97: Early life, and career beginnings[link]

Britney Jean Spears was born on December 2, 1981, the second child of Lynne Irene (née Bridges) and James Parnell Spears. She is of English heritage through her maternal grandmother, Lillian Portelli who was born in London, and of distant Maltese and Sicilian (Sicani) descent.^[15][16][17] Her siblings are Bryan James and Jamie Lynn.^[18] At age three, she started to attend dance lessons in her hometown of Kentwood, Louisiana, and was selected to perform as a solo artist at the annual recital. During her childhood, she also attended gymnastics and voice lessons, and won many state-level competitions and children's talent shows.^[19][20][21] Spears made her local stage debut at age five, singing "What Child Is This?" at her kindergarten graduation. She said about her ambition as a child, "I was in my own world, [...] I found out what I'm supposed to do at an early age".^[20] At age eight, Spears and her mother Lynne traveled to Atlanta for an audition in the 1990s revival of The Mickey Mouse Club. Casting director Matt Casella rejected her for being too young to join the series at the time, but introduced her to Nancy Carson, a New York City talent agent. Carson was impressed with Spears's vocals and suggested enrolling her at the Professional Performing Arts School; shortly after, Lynne and her daughters moved to a sublet apartment in New York. Spears was hired for her first professional role as the understudy for the lead role of Tina Denmark in the Off-Broadway musical Ruthless!. She also appeared as a contestant on the popular television show Star Search, as well as being cast in a number of commercials.^[22][23] In December 1992, she was finally cast in The Mickey Mouse Club, but returned to Kentwood after the show was canceled. She enrolled at Parklane Academy in nearby McComb, Mississippi. Although she made friends with most of her classmates, she compared the school to "the opening scene in Clueless with all the cliques. [...] I was so bored. I was the point guard on the basketball team. I had my boyfriend, and I went to homecoming and Christmas formal. But I wanted more."^[20][24]

In June 1997, Spears was in talks with manager Lou Pearlman to join the female pop group Innosense. Lynne asked family friend and entertainment lawyer Larry Rudolph for his opinion and submitted a tape of Spears singing over a Whitney Houston karaoke song along with some pictures. Rudolph decided he wanted to pitch her to record labels, therefore she needed a professional demo. He sent Spears an unused song of Toni Braxton; she rehearsed for a week and recorded her vocals in a studio with a sound engineer. Spears traveled to New York with the demo and met with executives from four labels, returning to Kentwood the same day. Three of the labels rejected her, arguing that audiences wanted pop bands such as the Backstreet Boys and the Spice Girls, and "there wasn't going to be another Madonna, another Debbie Gibson, or another Tiffany." Two weeks later, executives from Jive Records returned calls to Rudolph.^[25] Senior vice president of A&R Jeff Fenster stated about Spears's audition that "It's very rare to hear someone that age who can deliver emotional content and commercial appeal. [...] For any artist, the motivation—the 'eye of the tiger'—is extremely important. And Britney had that."^[20] She then sang Houston's "I Have Nothing" (1992) for the executives, and got signed to the label.^[26] They appointed her to work with producer Eric Foster White for a month, who reportedly shaped her voice from "lower and less poppy" delivery to "distinctively, unmistakably Britney."^[27] After hearing the recorded material, president Clive Calder ordered a full album. Spears had originally envisioned "Sheryl Crow music, but younger more adult contemporary" but felt all right with her label's appointment of producers, since "It made more sense to go pop, because I can dance to it—it's more me." She flew to Cheiron Studios in Stockholm, Sweden, where half of the album was recorded from March to April 1998, with producers Max Martin, Denniz Pop and Rami Yacoub, among others.^[20]

[edit] 1998–2000: ...Baby One More Time, and Oops!... I Did It Again

After Spears returned to the United States, she embarked on a shopping mall promotional tour to promote her forthcoming album. Her show was a four song set and she was accompanied by two back up dancers. Her first concert tour followed, as an opening act for 'N Sync.^[28] Her debut album, ...Baby One More Time, was released on January 1999.^[29] It debuted at number one on the U.S. Billboard 200 and was certified two-times platinum by the Recording Industry Association of America after a month. Worldwide, the album topped the charts in fifteen countries and sold over ten million copies in a year.^[30] It became the biggest selling album ever by a teenage artist.^[21] The title track was released as the lead single from the album. Originally, Jive Records wanted its music video to be animated; however, Spears rejected it, and suggested the final idea of a Catholic schoolgirl.^[27] The single sold 500,000 copies on its first day, and peaked at number one on the Billboard Hot 100, topping the chart for two consecutive weeks.^[31][32] "...Baby One More Time" later received a Grammy nomination for Best Female Pop Vocal Performance.^[33] The title track also topped the singles chart for two weeks in the United Kingdom, and became the fastest-selling single ever by a female artist, shipping over 460,000 copies.^[34] It would later become the 25th most successful song of all time in British chart history.^[35] Spears is also the youngest female artist to have a million seller in the country.^[36] "(You Drive Me) Crazy" was released as the third single from the album. It became a top-ten hit worldwide and propelled ...Baby One More Time to sell 26 million copies.^[37]

The April 1999 cover of Rolling Stone featured Spears lying on her bed, clad with a bra, shorts and an open top. The American Family Association (AFA) referred to the shoot as "a disturbing mix of childhood innocence and adult sexuality" and called to "God-loving Americans to boycott stores selling Britney's albums." Spears responded to the outcry commenting, "What's the big deal? I have strong morals. [...] I'd do it again. I thought the pictures were fine. And I was tired of being compared to Debbie Gibson and all of this bubblegum pop all the time."^[38] Shortly before, Spears had announced publicly she would remain a virgin until marriage.^[21] On June 28, 1999, Spears began her first headlining ...Baby One More Time Tour in North America, which was positively received by critics,^[39] but generated some controversy due to her racy outfits.^[40] An extension of the tour, titled Crazy 2k, followed in March 2000. Spears premiered songs from her upcoming second album during the show.^[24]

Oops!... I Did It Again, her second studio album, was released in May 2000. It debuted at number one in the US, selling 1,3 million copies, breaking the SoundScan record for the highest debut sales by any solo artist.^[41] The album sold over 20 million copies worldwide.^[42] Rob Sheffield of Rolling Stone said that "the great thing about Oops! – under the cheese surface, Britney's demand for satisfaction is complex, fierce and downright scary, making her a true child of rock & roll tradition."^[43] The album's lead single, "Oops!... I Did It Again", peaked at the top of the charts in Australia, New Zealand, the United Kingdom and many other European nations.^[36][44] The album as well as the title track received Grammy nominations for Best Pop Vocal Album and Best Female Pop Vocal Performance, respectively.^[45]

The same year, Spears embarked on the Oops!... I Did It Again World Tour, which grossed $40.5 million; she also released her first book, Britney Spears' Heart-to-Heart, co-written with her mother.^[21][46] On September 7, 2000, Spears performed at the 2000 MTV Video Music Awards. Halfway through the performance, she ripped off her black suit to reveal a sequined flesh-colored bodysuit, followed by heavy dance routine. It is noted by critics as the moment that Spears showed signs of becoming a more provocative performer.^[47] Amidst media speculation, Spears confirmed she was dating 'N Sync member Justin Timberlake.^[21]

[edit] 2001–03: Britney, Crossroads, and In the Zone

Spears performing at the NFL Kickoff Live in 2003.

In February 2001, Spears signed a $7–8 million promotional deal with Pepsi, and released another book co-written with her mother, entitled A Mother’s Gift.^[21] Her third studio album, Britney, was released in November 2001. While on tour, she felt inspired by hip hop artists such as Jay-Z and The Neptunes and wanted to create a record with a funkier sound.^[48] The album debuted at number one in the Billboard 200 and reached top five positions in Australia, the United Kingdom and mainland Europe and sold over 12 million copies worldwide.^[36][49][50] Stephen Thomas Erlewine of Allmusic called Britney "the record where she strives to deepen her persona, making it more adult while still recognizably Britney. [...] It does sound like the work of a star who has now found and refined her voice, resulting in her best record yet."^[51] The album was honored with two Grammy nominations—Best Pop Vocal Album and Best Female Pop Vocal Performance for "Overprotected"— and was listed in 2008 as one of Entertainment Weekly's "100 Best Albums from the Past 25 Years".^[52][53] The album's first single, "I'm a Slave 4 U", became a top-ten hit worldwide.^[54]

Spears's performance of the single at the 2001 MTV Video Music Awards featured a caged tiger and a large albino python draped over her shoulders. It was harshly received by animal rights organization PETA, who claimed the animals were mistreated and scrapped plans for an anti-fur billboard that was to feature Spears.^[47] To support the album, Spears embarked on the Dream Within a Dream Tour. The show was critically praised for its technical innovations, the pièce de résistance being a water screen that pumped two tons of water into the stage.^[55][56] The tour grossed $43.7 million, becoming the second highest grossing tour of 2002 by a female artist, behind Cher's Farewell Tour.^[57] Her career success was highlighted by Forbes in 2002, as Spears was ranked the world's most powerful celebrity.^[58] Spears also landed her first starring role in Crossroads, released in February 2002. Although the film was largely panned, most critics actually praised Spears's acting.^[59][60][61] Crossroads, which had a $11 million budget, went on to gross over $57 million worldwide.^[61]

In June 2002, Spears opened her first restaurant, Nyla, in New York City, but terminated her relationship in November, citing mismanagement and "management's failure to keep her fully apprised".^[62] In July 2002, Spears announced she would take a six month break from her career; however, she went back into the studio in November to record her new album.^[63] Spears' relationship with Justin Timberlake ended after three years. In December 2002, Timberlake released the song "Cry Me a River" as the second single from his solo debut album. The music video featured a Spears look-alike and fueled the rumors that she had been unfaithful to him.^[64][65] As a response, Spears wrote the ballad "Everytime" with her backing vocalist and friend Annet Artani.^[66] The same year, Limp Bizkit frontman Fred Durst said that he was in a relationship with Spears. However, Spears denied Durst's claims.^[67] In a 2009 interview, he explained that "I just guess at the time it was taboo for a guy like me to be associated with a gal like her."^[67] Spears opened the 2003 MTV Video Music Awards with Christina Aguilera, performing "Like a Virgin". Halfway through they were joined by Madonna, with whom they both kissed. The incident was highly publicized.^[61]

Spears released her fourth studio album, In the Zone, in November 2003. She assumed more creative control by writing and co-producing most of the material.^[21] Vibe called it "A supremely confident dance record that also illustrates Spears's development as a songwriter."^[68] NPR listed the album as one of "The 50 Most Important Recording of the Decade", adding that "the decade's history of impeccably crafted pop is written on her body of work."^[69] In the Zone sold over 609,000 copies in the United States and debuted at the top of the charts, making Spears the first female artist in the SoundScan era to have her first four studio albums to debut at number one.^[21] It also debuted at the top of the charts in France and the top ten in Belgium, Denmark, Sweden and the Netherlands.^[70] In the Zone sold over 10 million copies worldwide.^[71] The album produced the hit singles: "Me Against the Music", a collaboration with Madonna; "Toxic"—which won Spears her first and only Grammy for Best Dance Recording; "Everytime" and "Outrageous".^[21]

[edit] 2004–07: Compilation albums, motherhood, personal struggles, and Blackout

Spears performing live on The Onyx Tour in 2004

On January 3, 2004, Spears married childhood friend Jason Allen Alexander at The Little White Wedding Chapel in Las Vegas. The marriage was annulled 55 hours later, stating that Spears "lacked understanding of her actions".^[72] She began The Onyx Hotel Tour in support of In the Zone in March 2004.^[73] On June 8, 2004, Spears fell and injured her left knee during the music video shoot for "Outrageous". She was taken immediately to a local hospital, where doctors performed an MRI scan and found floating cartilage. The following day, Spears underwent arthroscopic surgery. She was forced to remain six weeks with a thigh brace, followed by eight to twelve weeks of rehabilitation, which caused The Onyx Hotel Tour to be canceled.^[74] During 2004, Spears became involved in the Kabbalah Centre through her friendship with Madonna.^[75]

In July 2004, she announced her engagement to American dancer Kevin Federline, whom she had met three months before. The romance received intense attention from the media, since Federline had recently broken up with actress Shar Jackson, who was still pregnant with their second child at the time.^[21] The initial stages of their relationship were chronicled in Spears's first reality show Britney & Kevin: Chaotic. They held a wedding ceremony on September 18, 2004, but were not legally married until three weeks later on October 6 due to a delay finalizing the couple's prenuptial agreement.^[76] Shortly after, she released her first fragrance with Elizabeth Arden, Curious, which broke the company's first-week gross for a perfume.^[21] In October 2004, Spears announced she would be taking another career break to start a family.^[77] Greatest Hits: My Prerogative, her first greatest hits compilation album, was released in November 2004.^[78] Spears's cover version of Bobby Brown's "My Prerogative" was released as the lead single from the album, reaching the top of the charts in Finland, Ireland, Italy and Norway.^[79] The second single, "Do Somethin'", was a top ten hit in Australia, the United Kingdom and other countries of mainland Europe.^[80][81] Worldwide, Greatest Hits: My Prerogative sold over 5 million copies.^[82] In late 2004, Spears went on KIIS-FM radio in Los Angeles, CA to play a new demo titled "Mona Lisa." The demo was to be the first single from an upcoming album called the "Original Doll." However, Spears' label later cancelled the album for unknown reasons.^[83][84] Spears gave birth to her first child, Sean Preston Federline, on September 14, 2005.^[85]

In November 2005, she released her first remix compilation, B in the Mix: The Remixes, which consists of eleven remixes.^[86] It has sold over 1 million copies worldwide, making it one of the best selling remix albums of all time.^[87] In February 2006, pictures surfaced of Spears driving with her son Sean, on her lap instead of in a car seat. Child advocates were horrified by the photos of her holding the wheel with one hand and Sean with the other. Spears claimed that the situation happened because of a frightening encounter with paparazzi, and that it was a mistake on her part.^[21] The following month, she guest-starred on the Will & Grace episode "Buy, Buy Baby" as closeted lesbian Amber Louise.^[88] She publicly announced she no longer studied Kabbalah in June 2006, explaining, "my baby is my religion."^[75] Two months later, Spears posed nude for the cover of Harper's Bazaar. The picture was heavily compared to Demi Moore's August 1991 Vanity Fair cover.^[21] She gave birth to her second child, Jayden James Federline, on September 12, 2006.^[89] On November 7, 2006, Spears filed for divorce from Federline, citing irreconcilable differences.^[90] Their divorce was finalized in July 2007, when the couple reached a global settlement and agreed to share joint custody of their children.^[91] Spears's aunt Sandra Bridges Covington, with whom she had been very close, died of ovarian cancer in January.^[92] On February 16, 2007, Spears stayed in a drug rehabilitation facility in Antigua for less than a day. The following night, she shaved her head with electric clippers at a hair salon in Tarzana, Los Angeles. She admitted herself to other treatment facilities during the following weeks.^[93] After completing a month-long program at Promises, she wrote on her website, "I truly hit rock bottom. Till this day I don't think that it was alcohol or depression. [...] was like a bad kid running around with ADD."^[21] In May 2007, she produced a series of promotional concerts at House of Blues venues, titled The M+M's Tour.^[94] Spears lost physical custody of her children to Federline on October 1, 2007. The reasons of the court ruling were not revealed to the public.^[95] Also, in 2007 Spears was sued by Louis Vuitton over her 2005 music video "Do Something" for pimping out her Hummer interior in counterfiet Louis Vuitton cherry blossom fabric. Which resulted in her video being banned on European TV stations.^[96]

Her fifth studio album, Blackout, was released in October 2007. It debuted at the top of charts in Canada and Ireland, number two in the U.S. Billboard 200,—held off from the top spot by Eagles's Long Road out of Eden— France, Japan, Mexico and the United Kingdom and the top ten in Australia, Korea, New Zealand and many European nations. In the United States, Spears became the only female artist to have her first five studio albums debut at the two top slots of the chart.^[97] Blackout sold over 3.1 million copies worldwide.^[98] Peter Robinson of The Observer said that "Britney has delivered the best album of her career, raising the bar for modern pop music with an incendiary mix of Timbaland's Shock Value and her own back catalogue."^[99] Dennis Lim of Blender commented, "Spears’s fifth studio album is her most consistent, a seamlessly entertaining collection of bright, brash electropop."^[100] Blackout won Album of the Year at MTV Europe Music Awards 2008 and was listed as the fifth Best Pop Album of the Decade by The Times.^[101][102] Spears performed the lead single "Gimme More" at the 2007 MTV Video Music Awards. The performance was panned by many critics. David Willis of BBC stated her performance would "go down in the history books as being one of the worst to grace the MTV Awards".^[103] Despite the backlash, the single rocketed to worldwide success, peaking at number one in Canada and the top ten in almost every country it charted.^[104][105] The second single "Piece of Me" reached the top of the charts in Ireland and reached the top five in Australia, Canada, Denmark, New Zealand and the United Kingdom. The third single "Break the Ice" was released the following year and had moderate success due to Spears not being able to promote it properly.^{[106][107][108]} In December 2007, Spears began a relationship with paparazzo Adnan Ghalib.^[109]

[edit] 2008–10: Conservatorship, and Circus

Spears performing "Freakshow" at The Circus Starring Britney Spears, 2009.

On January 3, 2008, Spears refused to relinquish custody of her sons to Federline's representatives. She was hospitalized at Cedars-Sinai Medical Center, after police that arrived at her house noted she appeared to be under the influence of an illicit substance. The following day, Spears's visitation rights were suspended at an emergency court hearing, and Federline was given sole physical and legal custody of the children. On January 31, 2008, Spears was committed to the psychiatric ward of Ronald Reagan UCLA Medical Center and put on 5150 involuntary psychiatric hold. The court placed her under temporary conservatorship of her father James Spears and attorney Andrew Wallet, giving them complete control of her assets.^[21] Spears was released on February 6, 2008. Her parents expressed disappointment and concern at the decision to release her.^[110] The following month, she guest-starred on the How I Met Your Mother episode "Ten Sessions" as receptionist Abby. She received positive reviews for her performance, as well as bringing the series its highest ratings ever.^[111][112] In July 2008, Spears regained some visitation rights after coming to an agreement with Federline and his counsel.^[113] On September 7, 2008, Spears opened the MTV Video Music Awards with a pre-taped comedy sketch with Jonah Hill and an introduction speech. She won Best Female Video, Best Pop Video and Video of the Year for "Piece of Me".^[114] A 60-minute introspective documentary, Britney: For the Record, was produced to chronicle Spears' return to the recording industry. Directed by Phil Griffin, For the Record was entirely shot in Beverly Hills, Hollywood, and New York City during the third quarter of 2008.^[115] Main shooting began on September 5, 2008, two days before Spears' appearance at the MTV Video Music Awards. For the Record was broadcast on MTV on November 30, 2008 to 5.6 million viewers for the two airings on the premiere night. MTV reported that Spears' documentary garnered on average, the highest rating in its Sunday night timeslot, in the network's history.^[116]

Her sixth studio album Circus, was released in December 2008. It received positive reviews from critics; according to the music review aggregation of Metacritic, it garnered an average score of 64/100.^[117] Circus debuted at number one in Canada, Czech Republic and the United States, and inside the top in many European nations.^[105][118] In the United States, Spears became the youngest female artist to have five albums debut at number one, earning a place in the Guinness Book of World Records.^[119] She also became the only act in the Soundscan era to have four albums debut with 500,000 or more copies sold.^[118] Circus became one of the fastest-selling albums of the year,^[120] and has sold 4 million copies worldwide.^[121][122] Its lead single, "Womanizer", became her first number one in the Billboard Hot 100 since "...Baby One More Time" and topped the charts in countries such as Belgium, Canada, Denmark, Finland, France, Norway and Sweden.^[123][124] It was also nominated for a Grammy in the category of Best Dance Recording.^[125] In January 2009, Spears and her father James obtained a restraining order against her former manager Sam Lufti, ex-boyfriend Adnan Ghalib and attorney Jon Eardley—all of whom, court documents claim, had been conspiring to gain control of Spears's affairs. The restraining order forbids Lutfi and Ghalib from contacting Spears or coming within 250 yards of her, her property or family members.^[126] Spears embarked on The Circus Starring Britney Spears in March 2009. With a gross of U.S. $131.8 million, it became the fifth highest grossing tour of the year.^[127]

She released her second greatest hits album, The Singles Collection in November 2009. "3" became her third number one single in the US, and was the first song to debut at the top of the charts in three years.^[128] Later that month, she released an application for iPhone and iPod Touch titled "It's Britney!".^[129] In May 2010, Spears's representatives confirmed she was dating her agent Jason Trawick, and that they had decided to end their professional relationship to focus on their personal relationship.^[130] Spears designed a limited edition clothing line for Candie's, which was released in stores in July 2010.^[131] On September 28, 2010, she made a cameo appearance on a Spears-themed tribute episode of American TV show Glee, titled "Britney/Brittany". Spears approved of the episode, although her appearances received mixed reviews from critics.^[132][133] The episode drew Glee's second largest audience, as well as the show's highest ratings ever.^[134][135]

[edit] 2011–present: Femme Fatale and The X Factor

Spears performing "Gimme More" at the Femme Fatale Tour, 2011.

In March 2011, Spears released her seventh studio album Femme Fatale.^[136] Max Martin and Dr. Luke executive produced the album and the album's first single "Hold It Against Me". The single debuted at number-one on the Billboard Hot 100. This gave Spears her fourth number-one single on the chart, and made her only the second artist in history to have two consecutive singles debut at number-one, after Mariah Carey.^[137] The album peaked at number one in the United States (selling 276,000 copies in its first week), Canada, and Australia, and peaked inside the top ten on nearly every other chart. The album's peak in the United States ties Britney with Mariah Carey and Janet Jackson for the third-most number ones among women.^[138] As of March 9, 2012, Femme Fatale has sold 883,000 copies in the United States and 2.2 million worldwide and has been certified platinum by the RIAA.^[139][140] The album received positive critical reviews after its release, receiving a score of 67 on Metacritic, her highest critical score since Oops!... I Did It Again, with many critics naming the album one of Spears's best.^[141] In April 2011, Spears appeared in a remix to the song "S&M" by Rihanna after Rihanna asked her fans via Twitter who they wanted her to collaborate with.^[142] The song reached number one in the US in mid-April 2011, giving Spears her fifth number one on the chart.^[143] In early May, Spears' second single from Femme Fatale, "Till The World Ends", reached number three on the Billboard Hot 100 and had ninety-eight million audience impressions on the Billboard chart, granting Spears the highest weekly audience of her 13-year chart career.^[144]

Femme Fatale's third single "I Wanna Go" reached the top forty on the Billboard Hot 100 in June 2011. Among females in the last thirteen years, Spears now has the third-most top forty hits, with twenty-one.^[145] In August, the single managed to reach the top-ten on the Billboard Hot 100, which is the first time for Spears to have three songs from one album in the top-ten.^[146] On the week ending September 24, 2011, "I Wanna Go" moved 2–1 on the mainstream top 40, becoming her sixth number-one on that chart (making her tied for third all-time) and her first number-one and third top-ten pop song for Femme Fatale.^[147] Spears now has the longest span of number ones on the mainstream top 40, with a length of twelve years, seven months, and four days.^[147] In October 2011, the music video for Femme Fatale's fourth single "Criminal" caused controversy when British politicians criticized Spears for using replica guns while filming the video in an area of London that had been badly affected by the 2011 England riots. Members of the Hackney London Borough Council felt Spears "promoted gun violence" and suggested that Spears apologize and make a donation to a Hackney charity.^[148] Spears's management briefly responded, stating, "The video is a fantasy story featuring Britney's boyfriend, Jason Trawick, which literally plays out the lyrics of a song written three years before the riots ever happened."^[149] Later that month, due to her continued popularity, Spears became the seventh artist to gain one billion cumulative views on her Vevo account.^[150] On Billboard's 2011 Year-End list, Spears was fourteen on the Artists of the Year,^[151] due to being 32 on Billboard 200 artists and 10 on Billboard Hot 100 artists.^[152][153] Additionally, many critics, including those at Rolling Stone, named "Till the World Ends" one of the best songs of 2011.^{[154][155][156]}

On March 2011, Spears announced that she would tour throughout the United States during summer 2011.^[157] The Femme Fatale Tour opened June 16 at the Power Balance Pavilion in Sacramento, California^[158] to positive reviews.^[159] Many critics noted that Spears sang more of the concert live in response to lip-synching accusations during The Circus Starring Britney Spears, and that the dancing is some of her best in years.^[159] The first ten US dates of the tour grossed $6.2 million, landing the fifty-fifth spot on Pollstar's Top 100 North American Tours list for the half-way point of the year.^[160] The tour ended on December 10, 2011 in Puerto Rico after 79 performances.^[161] A concert special of the tour was filmed in 2D and 3D in Canada on August 13 and 14. It premiered on November 12 on Epix, receiving mixed reviews.^{[162][163][164][165]} It was released to DVD on November 21^[166][167] and sold 19,000 copies, debuting at no. 2 on the US Billboard DVD Chart behind Lady Gaga's The Monster Ball Tour: At Madison Square Garden.^[168] Since its release, the DVD has been certified Platinum by the Recording Industry Association of America (RIAA),^[169] and Gold by the Australian Recording Industry Association (ARIA).^[170]

On June 15, 2011, it was announced by Billboard that the RCA/Jive Label Group would be splitting, with Jive Records being fully moved under RCA Records staying intact. In August it was announced that Spears had officially joined the RCA's roster.^[171][172] During the 2011 MTV Video Music Awards on August 28, 2011, MTV played tribute to Spears with a group of young female dancers that memorialised Britney's music videos, performances, and style. Following which, Spears accepted the MTV Video Vanguard Award from Lady Gaga, who said that "industry wouldn't be the same without [her]".^[173][174] On September 9, 2011, Spears announced her second remix album, B in the Mix: The Remixes Vol. 2, which was released on October 7, along with the tracklist.^[175] On October 7, RCA Music Group announced it was disbanding Jive Records along with Arista Records and J Records. With the shutdown, Spears (and all other artists previously signed to these three labels) will release her future material on the RCA Records brand.^[176][177]

On December 16, Spears confirmed her engagement to her long-time boyfriend Jason Trawick, her former agent.^[178] Spears revealed her three-carat diamond ring at a party in Las Vegas on December 17.^[179] According to Joe Riccitelli, the executive vice president of promotion for RCA Records, Spears would be taking time off during 2012.^[180] However, on January 30, 2012, will.i.am confirmed that he recorded a track with Spears, set to be included on his upcoming fourth studio album, #willpower (2012).^[181] It was also reported that Simon Cowell was in talks with Spears for her to join the new season of the The X-Factor.^[182] According to Billboard and The Hollywood Reporter, Trawick negotiated Spears' contract with the show,^[183] which was later approved by conservatorship judge Reva Goetz.^[184] Cowell and the producers of the show agreed to pay the singer $15 million for season two, and also added Trawick as a one of the producers for the season.^[185] The rumor was later confirmed to be true.^{[14][186][187]} Spears also teamed up with Hasbro to release an exclusive version of Twister Dance, which will include a remix of "Till the World Ends".^[188] The singer also participated on a commercial, which was directed by Ray Kay, to promote the game.^[188]

Artistry[link]

Musical style, and performance[link]

Following her debut, Spears was credited with leading the revival of teen pop in the late 1990s. The Daily Yomiuri reported that "[m]usic critics have hailed her as the most gifted teenage pop idol for many years, but Spears has set her sights a little higher-she is aiming for the level of superstardom that has been achieved by Madonna and Janet Jackson."^[189] Rob Sheffield of Rolling Stone wrote: "Britney Spears carries on the classic archetype of the rock & roll teen queen, the dungaree doll, the angel baby who just has to make a scene."^[190] Rami Yacoub who co-produced Spears's debut album with lyricist Max Martin, commented, "I know from Denniz Pop and Max's previous productions, when we do songs, there's kind of a nasal thing. With N' Sync and the Backstreet Boys, we had to push for that mid-nasal voice. When Britney did that, she got this kind of raspy, sexy voice."^[191] Following the release of her debut album, Chuck Taylor of Billboard observed, "Spears has become a consummate performer, with snappy dance moves, a clearly real-albeit young-and funkdified voice ... "(You Drive Me) Crazy", her third single ... demonstrates Spears's own development, proving that the 17-year-old is finding her own vocal personality after so many months of steadfast practice."^[192] Stephen Thomas Erlewine of Allmusic referred to her music as a "blend of infectious, rap-inflected dance-pop and smooth balladry."^[193] Spears later commented, "With ...Baby One More Time, I didn't get to show my voice off. The songs were great, but they weren't very challenging".^[194]

Oops!...I Did It Again and subsequent albums saw Spears working with several contemporary R&B producers, leading to "a combination of bubblegum, urban soul, and raga."^[195] Her third studio album, Britney derived from the teen pop niche, "[r]hythmically and melodically ... sharper, tougher than what came before. What used to be unabashedly frothy has some disco grit, underpinned by Spears' spunky self-determination that helps sell hooks that are already catchier, by and large, than those that populated her previous two albums."^[196] Guy Blackman of The Age wrote that while few would care to listen to an entire Spears album, "[t]he thing about Spears, though, is that her biggest songs, no matter how committee-created or impossibly polished, have always been convincing because of her delivery, her commitment and her presence. For her mostly teenage fans, Spears expresses perfectly the conflicting urges of adolescence, the tension between chastity and sexual experience, between hedonism and responsibility, between confidence and vulnerability."^[197]

"You Got It All" noicon The cover of The Jets song was the first song recorded by Spears for her then-label Jive in 1997.[198] The prominent use of melisma and vibratos as she continuously raises key into a high range was viewed as a Mariah Carey influence.[199] "Freakshow" noicon The track is built around the 'wobbler' effect of dubstep, and her vocals are pitched down low, making her sound masculine.[200][201] She was credited as one of the artists who prompted the genre within a pop mainstream audience.[202]

Problems listening to these files? See media help.