Bag (Bužim)

Bag is a settlement in Bužim, in Bosnia and Herzegovina.

External links

Coordinates: 44°00′N 18°07′E / 44.000°N 18.117°E / 44.000; 18.117

BAG3

BAG family molecular chaperone regulator 3 is a protein that in humans is encoded by the BAG3 gene. BAG3 is involved in chaperone-assisted selective autophagy (CASA).

Function

BAG proteins compete with Hip-1 for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Clinical significance

BAG gene has been implicated in age related neurodegenerative diseases such as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively. It has also been shown to be the cause of familial dilated cardiomyopathy. That BAG3 mutations are responsible for familial dilated cardiomyopathy is confirmed by another study describing 6 new molecular variants (2 missense and 4 premature Stops ). Moreover, the same publication reported that BAG3 polymorphisms are also associated with sporadic forms of the disease together with HSPB7 locus.

BAG1

BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.

Function

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.

Clinical significance

BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.

Interactions

BAG1 has been shown to interact with:

Pie (surname)

Pie is a surname. People with the surname include:

See also

Pie (game)

Pie or, Pieman, Pieman is an outdoor game for more than three children. Its origin is unknown. A variant exists called Easter Eggs.

Description

The game requires a seating area for the players (such as a flight of porch steps or a garden wall) which is designated the "Pie Shop" or "Bakery." Also required are a Goal distant from the seating area such as a tree, post or other object, and an expanse of lawn or field for a chase similar to the chase in the game of Tag.

One player is chosen Pieman, another Buyer, and the other players are Pies. The Buyer is sometimes designated Simple Simon following the Mother Goose rhyme:

To begin the game, the Buyer is sent to the Goal where he cannot see or hear the other players. The Pieman then names each Pie with a common pie filling such as Apple, Blueberry, Pumpkin, etc. When all the Pies have been named, the Pieman calls the Buyer to the Pie Shop.

The Buyer demands, "Pieman, Pieman, I would like a pie." The Pieman asks, "And what might that Pie be?" The Buyer then names a pie flavor such as Apple. If one of the Pies has been designated Apple, then he rushes from the Pie Shop to the Goal while the Buyer runs after him and attempts to tag him. Both the Pie and the Buyer must touch the Goal before running back to the Pie Shop. If the Pie returns to the Pie Shop without being tagged, he resumes his seat, and is renamed for another round. The chase may be complicated with dodging about lawn furniture, flower beds, clotheslines of drying laundry, or other obstacles in the path to and from the Goal.

List of Jo Stafford compilation albums

The following articles contain lists of Jo Stafford compilation albums:

Candy (unit)

The candy or candee (Marathi: खंडी, khaṇḍī;Tamil: கண்டி, kṇṭi;Malayalam: kaṇḍi,kaṇṭi), also known as the maunee, was a traditional South Asian unit of mass, equal to 20 maunds and roughly equivalent to 500 pounds avoirdupois (227 kilograms). It was most used in southern India, to the south of Akbar's empire, but has been recorded elsewhere in South Asia. In Marathi, the same word was also used for a unit of area of 120 bighas (25 hectares, very approximately), and it is also recorded as a unit of dry volume.

The candy was generally one of the largest (if not the largest) unit in a given system of measurement. The name is thought to be derived from the Sanskrit खण्डन (root खुड्) khaṇḍ, "to divide, break into pieces", which has also been suggested as the root of the term (sugar-)candy. The word was adopted into several South Asian languages before the compilation of dictionaries, presumably through trade as several Dravidian languages have local synonyms: for example ఖండి kaṇḍi and పుట్టి puṭṭi in Telugu.