Ebselen
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| Ebselen | |
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2-Phenyl-1,2-benzoselenazol-3-one |
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| Identifiers | |
| CAS number | 60940-34-3 |
| PubChem | 3194 |
| ChemSpider | 3082  |
| ChEMBL | CHEMBL51085 |
| Jmol-3D images | Image 1 Image 2 |
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| Properties | |
| Molecular formula | C13H9NOSe |
| Molar mass | 274.17666 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Ebselen or 2-phenyl-1, 2-benzisoselenazol-3(2H)-one (also called PZ 51 or DR3305), is a mimic of glutathione peroxidase and can also react with peroxynitrite.[1] It is being investigated as a possible treatment for reperfusion injury and stroke,[2][3] tinnitus,[4] and bipolar disorder.[5][6]
Ebselen is a potent scavenger of hydrogen peroxide as well as hydroperoxides including membrane bound phospholipid and cholesterylester hydroperoxides.
References[edit]
- ^ Schewe T (1995). "Molecular actions of ebselen--an antiinflammatory antioxidant". Gen Pharmacol 26 (6): 1153–69. doi:10.1016/0306-3623(95)00003-J. PMID 7590103.
- ^ Parnham M, Sies H (2000). "Ebselen: prospective therapy for cerebral ischaemia". Expert Opin Investig Drugs 9 (3): 607–19. doi:10.1517/13543784.9.3.607. PMID 11060699.
- ^ Yamaguchi T, Sano K, Takakura K, Saito I, Shinohara Y, Asano T, Yasuhara H (1 January 1998). "Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group". Stroke 29 (1): 12–7. doi:10.1161/01.STR.29.1.12. PMID 9445321.
- ^ Kil, Jonathan; Pierce, Carol; Tran, Huy; Gu, Rende; Lynch, Eric D (2007). "Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidase". Hearing Research 226 (1–2): 44–51. doi:10.1016/j.heares.2006.08.006. PMID 17030476.
- ^ Singh, N.; Halliday, A. C.; Thomas, J. M.; Kuznetsova, O. V.; Baldwin, R.; Woon, E. C. Y.; Aley, P. K.; Antoniadou, I. et al. (2013). "A safe lithium mimetic for bipolar disorder". Nature Communications 4: 1332. doi:10.1038/ncomms2320. PMID 23299882.
- ^ "New drug for bipolar disorder may offer fewer side effects". University of Oxford Latest News. 2013-01-08. Retrieved 12 January 2013.
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