- published: 05 Nov 2016
- views: 347
Period (per) is a gene located on the X chromosome of Drosophila melanogaster. Oscillations in levels of both per transcript and its corresponding protein PER have a period of approximately 24 hours and together play a central role in the molecular mechanism of the Drosophila biological clock driving circadian rhythms in eclosion and locomotor activity. Mutations in the per gene can shorten (perS), lengthen (perL), and even abolish (per0) the period of the circadian rhythm.
The period gene and three mutants (perS, perL, and per0) were isolated in an EMS mutagenesis screen by Ronald Konopka and Seymour Benzer in 1971. The perS, perL, and per0 mutations were found to complement each other, so it was concluded that the three phenotypes were due to mutations in the same gene. The discovery of mutants that altered the period of circadian rhythms in eclosion and locomotor activity (perS and perL) indicated the role of the per gene in the clock itself and not an output pathway. The period gene was first sequenced in 1984 by Michael Rosbash and colleagues. In 1998, it was discovered that per produces two transcripts (differing only by the alternative splicing of a single untranslated intron) which both encode the PER protein.
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Michael Rosbash (born March 7, 1944) is an American geneticist and chronobiologist. Rosbash is a professor at Brandeis University and investigator at the Howard Hughes Medical Institute. Rosbash's research group cloned the Drosophila period gene in 1984 and proposed the Transcription Translation Negative Feedback Loop for circadian clocks in 1990. In 1998, they discovered the cycle gene, clock gene, and cryptochrome photoreceptor in Drosophila through the use of forward genetics, by first identifying the phenotype of a mutant and then determining the genetics behind the mutation. Rosbash was elected to the National Academy of Sciences in 2003.
Michael Rosbash was born in Kansas City, Missouri. His parents were immigrants who had fled Nazi Germany in 1938. His father was a cantor, which, in Judaism, is a person who leads the congregation in prayer. Rosbash’s family moved to Boston when he was two years old, and he has been an avid Red Sox fan ever since.
Initially, Rosbash was interested in mathematics but an undergraduate biology course at the California Institute of Technology (Caltech) and a summer of working in Norman Davidson’s lab steered him towards biological research. Rosbash graduated from Caltech in 1965 with a degree in chemistry, spent a year at the Institut de Biologie Physico-Chimique in Paris on the Fulbright Scholarship, and obtained a doctoral degree in biophysics in 1970 from the Massachusetts Institute of Technology. After spending three years on a postdoctoral degree in genetics at the University of Edinburgh, Rosbash joined the Brandeis University faculty in 1974.
The suprachiasmatic nuclei (SCN) are thought to be involved with maintaining circadian rhythms, or biological patterns that follow a 24-hour cycle. To accomplish this, the cells of the SCN contain biological clocks. In this video, I discuss the molecular mechanism driving the biological clocks in the cells of the mammalian SCN, and how a cycle of gene expression allows the activity of these cells to follow a 24-hour pattern. TRANSCRIPT: Welcome to 2 minute neuroscience, where I simplistically explain neuroscience topics in 2 minutes or less. In this installment I will discuss the suprachiasmatic nucleus. The suprachiasmatic nuclei, or SCN, are two small, paired nuclei found in the hypothalamus; they are involved in maintaining circadian rhythms, or biological patterns that follow a 24-h...
http://www.iBiology.org Michael Rosbash tells the story of how a collaboration with friend Jeff Hall led to the discovery of the genetic mechanisms that regulate circadian rhythms in organisms. Circadian rhythms are the physiological and behavioral changes, such as sleep and wakefulness, which occur in response to a 24-hour cycle of light and darkness. Using Drosophila as a model, Rosbash and Hall cloned the circadian timekeeping gene called period. They observed period's expression oscillates in 24-hour cycles, which they later demonstrated result from the period protein blocking its own transcription through an oscillating negative feedback loop. Temporally controlled negative feedback at the transcriptional level is now known as a ubiquitous feature of circadian timekeeping in mammals,...
"A lab research project for the 2014 Student Bio Expo by Lindsey Giffey." This is a description of how research was conducted in order to determine if there was a specific light pattern that could be used in order to decrease the effects of Jet Lag.
Please Subscribe! http://testu.be/1FjtHn5 Early humans migrated all over the world to get us where we are today. The environments our ancestors inhabited made us all very different! + + + + + + + + TestTube Plus is built for enthusiastic science fans seeking out comprehensive conversations on the geeky topics they love. Host Trace Dominguez digs beyond the usual scope to deliver details, developments and opinions on advanced topics like AI, string theory and Mars exploration. TestTube Plus is also offered as an audio podcast on iTunes. + + + + + + + + Trace Dominguez on Twitter https://twitter.com/TraceDominguez TestTube on Facebook https://facebook.com/testtubenetwork TestTube on Google+ http://gplus.to/TestTube + + + + + + + +
Lecture Overview: Circadian rhythms are an adaptation to the 24 hr day that we experience. Takahashi begins his talk with an historic overview of how the genes controlling circadian clocks were first identified in Drosophila and the cloning tour de force that was required to identify clock genes in mice. He also describes the experiments that resulted in the realization that all cells in the body have a circadian clock, not just cells in the brain. In part 1B, Takahashi explains that the suprachiasmatic nucleus (SCN) in the brain generates a circadian rhythm of fluctuating body temperature that, in turn, signals to peripheral tissues. Heat shock factor 1 is one of the signaling molecules responsible for communicating the temperature information and resetting peripheral clocks. In Part ...
Menstruation is amazing and we explain why! SUBSCRIBE! http://bit.ly/10kWnZ7 Check out iiSuperwomanii: http://bit.ly/1u1FaQs ---Links to follow us below!--- Instagram and Twitter: @whalewatchmeplz and @mitchellmoffit Clickable: http://bit.ly/16F1jeC and http://bit.ly/15J7ube Facebook: http://on.fb.me/1fjWszw Twitter: http://bit.ly/1d84R71 Tumblr: http://bit.ly/1amIPjF Vine: Search "AsapSCIENCE" on vine! Links for Lilly--- Facebook: http://facebook.com/iisuperwomanii Twitter: http://twitter.com/iisuperwomanii Written and created by: Mitchell Moffit (twitter @mitchellmoffit) and Gregory Brown (twitter @whalewatchmeplz). Send us stuff! ASAPSCIENCE INC. P.O. Box 93, Toronto P Toronto, ON, M5S2S6 Further Reading: Evaluation of Psychological Symptoms in Premenstrual Syndrome using PMR T...
BuzzFeed had three male volunteers agree to experience physical periods for an entire week. Edgar, Shane and Zachary join The Doctors to discuss what it was like, along with Auri, the BuzzFeed producer who put them up to it. Subscribe to The Doctors: http://bit.ly/SubscribeTheDrs LIKE us on Facebook: http://bit.ly/FacebookTheDoctors Follow us on Twitter: http://bit.ly/TheDrsTwitter Follow us on Pinterest: http://bit.ly/PinterestTheDrs About The Doctors: The Doctors is an Emmy award-winning daytime talk show hosted by ER physician Dr. Travis Stork, plastic surgeon Dr. Andrew Ordon, OB-GYN Dr. Jennifer Ashton, urologist Dr. Jennifer Berman and family medicine physician and sexologist Dr. Rachael Ross. The Doctors helps you understand the latest health headlines, such as the ice bucket ch...
From the TLC documentary 'Wild Child :The Story Of Feral Children'. Susan M. Wiley(B. Apr. 18. 1957) 6722 N. Golden West Ave. Arcadia,CA 91007 She was not a wild child, she was an extremely abused child. http://www.youtube.com/watch?v=xtgnjRY_Z7w http://abcnews.go.com/Health/story?id=4804490&page;=1#.UYgsK0odfCp http://www.youtube.com/watch?v=hmdycJQi4QA http://www.youtube.com/watch?v=j3oy6vK7gsg http://www.cultureunplugged.com/play/7847/Born-Genius--My-Brilliant-Brain
The suprachiasmatic nuclei (SCN) are thought to be involved with maintaining circadian rhythms, or biological patterns that follow a 24-hour cycle. To accomplish this, the cells of the SCN contain biological clocks. In this video, I discuss the molecular mechanism driving the biological clocks in the cells of the mammalian SCN, and how a cycle of gene expression allows the activity of these cells to follow a 24-hour pattern. TRANSCRIPT: Welcome to 2 minute neuroscience, where I simplistically explain neuroscience topics in 2 minutes or less. In this installment I will discuss the suprachiasmatic nucleus. The suprachiasmatic nuclei, or SCN, are two small, paired nuclei found in the hypothalamus; they are involved in maintaining circadian rhythms, or biological patterns that follow a 24-h...
http://www.iBiology.org Michael Rosbash tells the story of how a collaboration with friend Jeff Hall led to the discovery of the genetic mechanisms that regulate circadian rhythms in organisms. Circadian rhythms are the physiological and behavioral changes, such as sleep and wakefulness, which occur in response to a 24-hour cycle of light and darkness. Using Drosophila as a model, Rosbash and Hall cloned the circadian timekeeping gene called period. They observed period's expression oscillates in 24-hour cycles, which they later demonstrated result from the period protein blocking its own transcription through an oscillating negative feedback loop. Temporally controlled negative feedback at the transcriptional level is now known as a ubiquitous feature of circadian timekeeping in mammals,...
"A lab research project for the 2014 Student Bio Expo by Lindsey Giffey." This is a description of how research was conducted in order to determine if there was a specific light pattern that could be used in order to decrease the effects of Jet Lag.
Please Subscribe! http://testu.be/1FjtHn5 Early humans migrated all over the world to get us where we are today. The environments our ancestors inhabited made us all very different! + + + + + + + + TestTube Plus is built for enthusiastic science fans seeking out comprehensive conversations on the geeky topics they love. Host Trace Dominguez digs beyond the usual scope to deliver details, developments and opinions on advanced topics like AI, string theory and Mars exploration. TestTube Plus is also offered as an audio podcast on iTunes. + + + + + + + + Trace Dominguez on Twitter https://twitter.com/TraceDominguez TestTube on Facebook https://facebook.com/testtubenetwork TestTube on Google+ http://gplus.to/TestTube + + + + + + + +
Lecture Overview: Circadian rhythms are an adaptation to the 24 hr day that we experience. Takahashi begins his talk with an historic overview of how the genes controlling circadian clocks were first identified in Drosophila and the cloning tour de force that was required to identify clock genes in mice. He also describes the experiments that resulted in the realization that all cells in the body have a circadian clock, not just cells in the brain. In part 1B, Takahashi explains that the suprachiasmatic nucleus (SCN) in the brain generates a circadian rhythm of fluctuating body temperature that, in turn, signals to peripheral tissues. Heat shock factor 1 is one of the signaling molecules responsible for communicating the temperature information and resetting peripheral clocks. In Part ...
Menstruation is amazing and we explain why! SUBSCRIBE! http://bit.ly/10kWnZ7 Check out iiSuperwomanii: http://bit.ly/1u1FaQs ---Links to follow us below!--- Instagram and Twitter: @whalewatchmeplz and @mitchellmoffit Clickable: http://bit.ly/16F1jeC and http://bit.ly/15J7ube Facebook: http://on.fb.me/1fjWszw Twitter: http://bit.ly/1d84R71 Tumblr: http://bit.ly/1amIPjF Vine: Search "AsapSCIENCE" on vine! Links for Lilly--- Facebook: http://facebook.com/iisuperwomanii Twitter: http://twitter.com/iisuperwomanii Written and created by: Mitchell Moffit (twitter @mitchellmoffit) and Gregory Brown (twitter @whalewatchmeplz). Send us stuff! ASAPSCIENCE INC. P.O. Box 93, Toronto P Toronto, ON, M5S2S6 Further Reading: Evaluation of Psychological Symptoms in Premenstrual Syndrome using PMR T...
BuzzFeed had three male volunteers agree to experience physical periods for an entire week. Edgar, Shane and Zachary join The Doctors to discuss what it was like, along with Auri, the BuzzFeed producer who put them up to it. Subscribe to The Doctors: http://bit.ly/SubscribeTheDrs LIKE us on Facebook: http://bit.ly/FacebookTheDoctors Follow us on Twitter: http://bit.ly/TheDrsTwitter Follow us on Pinterest: http://bit.ly/PinterestTheDrs About The Doctors: The Doctors is an Emmy award-winning daytime talk show hosted by ER physician Dr. Travis Stork, plastic surgeon Dr. Andrew Ordon, OB-GYN Dr. Jennifer Ashton, urologist Dr. Jennifer Berman and family medicine physician and sexologist Dr. Rachael Ross. The Doctors helps you understand the latest health headlines, such as the ice bucket ch...
From the TLC documentary 'Wild Child :The Story Of Feral Children'. Susan M. Wiley(B. Apr. 18. 1957) 6722 N. Golden West Ave. Arcadia,CA 91007 She was not a wild child, she was an extremely abused child. http://www.youtube.com/watch?v=xtgnjRY_Z7w http://abcnews.go.com/Health/story?id=4804490&page;=1#.UYgsK0odfCp http://www.youtube.com/watch?v=hmdycJQi4QA http://www.youtube.com/watch?v=j3oy6vK7gsg http://www.cultureunplugged.com/play/7847/Born-Genius--My-Brilliant-Brain
Gene Hill speaking on the 39th Annual Bellview Lectures at Bellview Church of Christ in Pensacola, FL
Crimson Tide is a 1995 American submarine film directed by Tony Scott, produced by Don Simpson and Jerry Bruckheimer. It takes place during a period of political turmoil in the Russian Federation, in which ultranationalists threaten to launch nuclear missiles at the United States and Japan. It focuses on a clash of wills between the new executive officer (Denzel Washington) of a U.S. nuclear missile submarine and its seasoned commanding officer (Gene Hackman), arising from conflicting interpretations of an order to launch their missiles. The film was scored by Hans Zimmer, who won a Grammy Award for the main theme, which makes heavy use of synthesizers in place of traditional orchestral instruments. CLICK TO SEE OTHER FILMS : https://goo.gl/48hQQ2
http://mendellectures.muni.cz/home/lectures/20142015#_lect_back5 Michael Rosbash (born March 7, 1944) is an American geneticist and chronobiologist. He is a professor at Brandeis University and investigator at the Howard Hughes Medical Institute. The Rosbash laboratory is interested in RNA processingas well as the genes and mechanisms that underlie circadian rhythms. Rosbash's research group cloned the Drosophila period gene in 1984 and in 1990 proposed that PER is important for a negative-feedback loop of gene expression and that transcription of the per gene itself is affected. As PER was shown to be nuclear, they proposed that it rather directly inhibits the transcription of its own mRNA.Their current circadian work has three major goals: (1) to understand in mechanistic detail how t...
http://mendellectures.muni.cz/home/lectures/20152016#_lect_back1 Michael Rosbash (born March 7, 1944) is an American geneticist and chronobiologist. He is a professor at Brandeis University and investigator at the Howard Hughes Medical Institute. The Rosbash laboratory is interested in RNA processingas well as the genes and mechanisms that underlie circadian rhythms. Rosbash's research group cloned the Drosophila period gene in 1984 and in 1990 proposed that PER is important for a negative-feedback loop of gene expression and that transcription of the per gene itself is affected. As PER was shown to be nuclear, they proposed that it rather directly inhibits the transcription of its own mRNA.Their current circadian work has three major goals: (1) to understand in mechanistic detail how t...
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TRACK LISTING: 01. Runnin' with the Devil [version 1] - 0:00 02. Let's Get Rockin' - 3:23 03. Eyes of the Night - 6:25 04. Big Trouble - 10:41 05. House of Pain - 14:15 06. Show Your Love [live] - 17:48 07. Somebody Get Me a Doctor [version 1] - 22:24 08. On Fire [version 1] - 25:26 09. Last Night - 29:01 10. We Die Bold - 32:41 11. Put Out the Lights - 36:37 We all know Van Halen rules, but have you ever wondered what their albums might have sounded like if they were able to record a few of them during their club days? While we'll never know the answer to that question, I've attempted to do the next best thing and compiled a series of fantasy releases covering the group's formative years. These albums will hopefully serve as both a road map for the casual fan who'd like to learn more a...
Set in profound space, the arrangement rotates around the experiences of Dylan Hunt, commander of the Andromeda Ascendant, his group individuals, and their endeavors to reestablish the Systems Commonwealth, a legislature that was in charge of a period of developed peace and thriving. The science fiction arrangement depends on beforehand unused materials composed by late author Gene Roddenberry.
Set in profound space, the arrangement rotates around the experiences of Dylan Hunt, commander of the Andromeda Ascendant, his group individuals, and their endeavors to reestablish the Systems Commonwealth, a legislature that was in charge of a period of developed peace and thriving. The science fiction arrangement depends on beforehand unused materials composed by late author Gene Roddenberry.