Nerves (yellow)

A nerve is any of the filamentous bands of nervous tissue that connect parts of the peripheral nervous system with other organs. It is made up of axons and dendrites which have protective and supportive structures. A nerve provides a common pathway for the electrochemical nerve impulses that are transmitted along each of the axons. It is made up of axons and dendrites which have protective and supportive structures. A nerve provides a common pathway for the electrochemical nerve impulses that are transmitted along each of the axons.

In the central nervous system, the analogous structures are known as tracts.^[1][2] Neurons are sometimes called nerve cells, though this term is potentially misleading since many neurons do not form nerves, and nerves also include non-neuronal Schwann cells that coat the axons in myelin.

Each nerve is a cordlike structure that contains many axons. These axons are often referred to as “fibres”. Within a nerve, each axon is surrounded by a layer of connective tissue called the endoneurium. The axons are bundled together into groups called fascicles, and each fascicle is wrapped in a layer of connective tissue called the perineurium. Finally, the entire nerve is wrapped in a layer of connective tissue called the epineurium.

Anatomy[link]

Nerves are categorized into three groups based on the direction that signals are conducted:

• Afferent nerves conduct signals from sensory neurons to the central nervous system, for example from the mechanoreceptors in skin.
• Efferent nerves conduct signals from the central nervous system along motor neurons to their target muscles and glands.
• Mixed nerves contain both afferent and efferent axons, and thus conduct both incoming sensory information and outgoing muscle commands in the same bundle.

Nerves can be categorized into two groups based on where they connect to the central nervous system:

• Spinal nerves innervate much of the body, and connect through the spinal column to the spinal cord. They are given letter-number designations according to the vertebra through which they connect to the spinal column.
• Cranial nerves innervate parts of the head, and connect directly to the brain (especially to the brainstem). They are typically assigned Roman numerals from 1 to 12, although cranial nerve zero is sometimes included. In addition, cranial nerves have descriptive names.

Cross-section of a nerve

Each nerve is covered externally by a dense sheath of connective tissue, the epineurium. Underlying this is a layer of flat cells, the perineurium, which forms a complete sleeve around a bundle of axons. Perineurial septae extend into the nerve and subdivide it into several bundles of fibers. Surrounding each such fiber is the endoneurium. This forms an unbroken tube which extends from the surface of the spinal cord to the level at which the axon synapses with its muscle fibers, or ends in sensory receptors. The endoneurium consists of an inner sleeve of material called the glycocalyx and an outer, delicate, meshwork of collagen fibers. Nerves are bundled along with blood vessels, since the neurons of a nerve have fairly high energy requirements. Within the endoneurium, the individual nerve fibers are surrounded by a low protein liquid called endoneurial fluid. The endoneurium has properties analogous to the blood–brain barrier, in that it prevents certain molecules from crossing from the blood into the endoneurial fluid. In this respect, endoneurial fluid is similar to cerebro-spinal fluid in the central nervous system. During the development of nerve edema from nerve irritation or (injury), the amount of endoneurial fluid may increase at the site of irritation. This increase in fluid can be visualized using magnetic resonance neurography, and thus MR neurography can identify nerve irritation and/or injury.

Physiology[link]

A nerve conveys information in the form of electrochemical impulses (known as nerve impulses or action potentials) carried by the individual neurons that make up the nerve. These impulses are extremely fast, with some myelinated neurons conducting at speeds up to 120 m/s. The impulses travel from one neuron to another by crossing a synapse, the message is converted from electrical to chemical and then back to electrical.^[1][2]

Nerves can be categorized into two groups based on function:

• Sensory nerves conduct sensory information from their receptors to the central nervous system, where the information is then processed. Thus they are synonymous with afferent nerves.
• Motor nerves conduct signals from the central nervous system to muscles. Thus they are synonymous with efferent nerves.^[1][2]

Clinical importance[link]

Micrograph demonstrating perineural spread of prostate cancer. H&E stain.

Damage to nerves can be caused by physical injury or swelling (e.g. carpal tunnel syndrome), autoimmune diseases (e.g. Guillain-Barré syndrome), infection (neuritis), diabetes or failure of the blood vessels surrounding the nerve. A pinched nerve occurs when pressure is placed on a nerve, usually from swelling due to an injury or pregnancy. Nerve damage or pinched nerves are usually accompanied by pain, numbness, weakness, or paralysis. Patients may feel these symptoms in areas far from the actual site of damage, a phenomenon called referred pain. Referred pain occurs because when a nerve is damaged, signalling is defective from all parts of the area from which the nerve receives input, not just the site of the damage. Neurologists usually diagnose disorders of the nerves by a physical examination, including the testing of reflexes, walking and other directed movements, muscle weakness, proprioception, and the sense of touch. This initial exam can be followed with tests such as nerve conduction study and electromyography (EMG).

Cancer[link]

Cancer can spread along nerves; this is known as perineural spread and often is associated with a worse prognosis.

Growth and stimulation[link]

Nerve growth normally ends in adolescence, but can be re-stimulated with a molecular mechanism known as "Notch signaling."^[3]

See also[link]

• Nerve fiber
• Peripheral nerve injury (Nerve injury)
• Connective tissue in the peripheral nervous system
• Neuropathy
• Peripheral nerve injury classification
• Dermatome (Anatomy)

Additional images[link]

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References[link]

Wikimedia Commons has media related to: Nerves

Jojo Mayer
Background information
Birth name	Serge Mayer [1]
Born	(1963-01-18) 18 January 1963 (age 49) Zurich, Switzerland
Genres	Drum and bass, jazz, jungle, fusion
Occupations	Musician
Instruments	Drums
Years active	1981–present
Associated acts	Nerve, Screaming Headless Torsos, Intergalactic Maiden Ballet, John Medeski, Meshell Ndegeocello, Dizzy Gillespie, Nina Simone
Website	www.jojomayer.com
Notable instruments
Sonor Drum kit, Sabian Cymbals, Evans Drumheads, Vic Firth Drumsticks

Jojo Mayer (born 18 January 1963) is a highly acclaimed Swiss drummer born in Zurich and currently residing in New York City.

Mayer is the son of a touring musician and began his career as a drummer at an early age, receiving his first drum set at the age of two. Having taught himself throughout his childhood, he broke out into the professional music scene at the age of 18, joining the Monty Alexander group. Touring with the group launched him into the major jazz music scene, and he has played at the North Sea Jazz Festival, Montreux, Nice, and Athens etc., which culminated with his gigging with jazz-greats such as Dizzy Gillespie and Nina Simone. Eventually, after playing with a great variety of artists, Mayer moved away from jazz and into Drum 'n' Bass.^[2]

Jojo Mayer is known for bringing together jazz, drum and bass, jungle, and other influences. He is also famous for his ability to play the rhythms of programmed jungle drum 'n' bass music on acoustic drums, terming this technique "reverse engineering", a phrase borrowed from computing.^[2] He executes this approach using various methods such as the heel-toe bass drum technique, the Moeller stroke, and the "pull-out" or "push-pull" accent which takes the beat on the rebound. Using these techniques, he can play beats at astonishing speeds. A few of his main influences are Tony Williams, Jack DeJohnette and Buddy Rich.

He is the leader of live electronica trio Nerve, which he founded in 1997.

He played with the guitarist David Fiuczynski in the avant-garde pop rock band Screaming Headless Torsos and in the fusion jazz band, Intergalactic Maiden Ballet.

He ran the popular Prohibited Beatz live electronica party in NYC from 1996-2001.

Discography[link]

With Intergalactic Maiden Ballet:

• 1992 - Square Dance
• 1994 - Gulf

With John Medeski:

• 1994 - Lunar Crush

With Screaming Headless Torsos:

• 1995 - Screaming Headless Torsos

With Harry Sokal:

• 1996 - Rave the Jazz! :live:

Sulfur:

• 1998 - Delirium Tremens

With Janek Gwizdala:

• 2004 - Mystery To Me - Live in New York
• 2010 - The Space In Between
• 2011 - Live at the Jamboree June 17th 2011 1st set
• 2011 - Live at the Jamboree June 17th 2011 2nd set
• 2011 - Live at the Jamboree June 18th 2011 1st set
• 2011 - Live at the Jamboree June 18th 2011 2nd set

With Depart

• 2006 - Reloaded
• 2008 - Mountain Messenger

Jojo Mayer & Nerve:

• 2007 - Prohibited Beats
• 2010 - EP1
• 2010 - EP2
• 2011 - EP3
• 2011 - The Distance Between Zero And One

Media[link]

He was featured as the cover story of the January 2008 issue of Modern Drummer magazine. His DVD, Secret Weapons for the Modern Drummer, is a bestseller worldwide.

Jojo Mayer was interviewed by DrummerConnection.com - May 2010 - Jojo Mayer Interview by DrummerConnection.com

Jojo Mayer was interviewed by Linus Wyrsch on "The Jazz Hole" for breakthruradio.com in July 2010 - Jojo Mayer Interview by breakthruradio.com

Gear[link]

Mayer is a long-time Sonor endorser who also uses Sabian cymbals and Vic Firth sticks. He helped Sonor design the Jungle kit and snare. He has also collaborated with Sabian to create two lines of cymbals, the Vault "Fierce" series, and the AAX "Omni" series. His Vault Fierce cymbals feature a raw, unlathed finish, and extensive hand hammering, while the Omnis are designed to function as both rides and crashes. Mayer usually uses birch Sonor drums in the following sizes:

14" and 13" Snare Drum

10" Tom Tom

14" Floor Tom

8" Tom to the right of the Floor Tom

20" or 18" Bass Drum

Sizes may vary primarily based on local drum availability.

For drumheads (all Evans):

14" Hybrid Coated

14" Hazy 300

12" G Plus Clear

12" G Plus Coated

12" Hydraulic Black

12" Hydraulic Glass

For cymbals, he's recently been using (all Sabian):

22" AAX Omni

18" Fierce Crash

18" AAX Omni

13" El Sabor Splash

13" HHX Evolution Top Hi Hat over 14" HHX Evolution Mini-China

10" Fierce Hi Hats

13" Fierce Hi Hats

10" Chopper

References[link]

External links[link]

• Jojo Mayer’s homepage
• Jojo Mayer's Nerve Info at Basitours
• Myspace Page
• JoJo Mayer Interview by DrummerConnection.com - 5 May 2010

Nigel Farage MEP
Leader of the United Kingdom Independence Party
Incumbent
Assumed office 5 November 2010
Preceded by	Jeffrey Titford
In office 27 September 2006 – 27 November 2009
Preceded by	Roger Knapman
Succeeded by	Lord Pearson of Rannoch
Member of the European Parliament for South East England
Incumbent
Assumed office 15 July 1999
Personal details
Born	(1964-04-03) 3 April 1964 (age 48) Kent, England, United Kingdom
Nationality	British
Political party	UK Independence Party
Spouse(s)	Gráinne Hayes (1988-1997, divorced) Kirsten Mehr (1999-present)
Children	4
Alma mater	Dulwich College
Religion	Church of England
Website	Nigel Farage MEP

Nigel Paul Farage ( /ˈfærɑːʒ/, FARR-ahzh;^[1] born 3 April 1964, Farnborough, Kent), is a British politician and is the Leader of the UK Independence Party (UKIP),^[2] a position he also held from September 2006 to November 2009. He is a Member of the European Parliament for South East England and co-chairs the Eurosceptic Europe of Freedom and Democracy group.

Farage is a founding member of the UKIP, having left the Conservative Party in 1992 after they signed the Maastricht Treaty. Having unsuccessfully campaigned in European and Westminster parliamentary elections for UKIP since 1994, he gained a seat as an MEP for South East England in the 1999 European Parliament Election — the first year the regional list system was used — and was re-elected in 2004 and 2009. Farage describes himself as a libertarian and rejects the notion that he is a conservative.

In September 2006, Farage became the UKIP Leader and led the party through the 2009 European Parliament Election in which it received the second highest share of the popular vote, defeating Labour and the Liberal Democrats with over two million votes. However he stepped down in November 2009 to concentrate on contesting the Speaker John Bercow's seat of Buckingham in the 2010 general election.

At the 2010 General Election, Farage failed to unseat John Bercow and received only the third highest share of the vote in the constituency. Shortly after the polls opened on 6 May 2010, Nigel Farage was injured in an aircraft crash in Northamptonshire. The two-seated PZL-104 Wilga 35A had been towing a pro-UKIP banner when it flipped over and crashed shortly after takeoff. Both Farage and the pilot were hospitalised with non-life-threatening injuries.^[3]

In November 2010, Farage successfully stood in the 2010 UKIP leadership contest,^[4] following the resignation of its leader, Lord Pearson of Rannoch. Farage was also ranked 41st (out of 100) in The Daily Telegraph's Top 100 most influential right-wingers poll in October 2009, citing his media savvy and his success with UKIP in the European Elections.^[5] Farage was ranked 58th in the 2010 list compiled by Iain Dale and Brian Brivati for the Daily Telegraph.

Background[link]

Farage was educated at Dulwich College before joining a commodity brokerage firm in London. He ran his own brokerage business from the early 1990s until 2002. In his early 20s Farage was diagnosed with testicular cancer but made a full recovery.^[6]

Farage has been married twice. He married Gráinne Hayes in 1988, with whom he had two children: Samuel (1989) and Thomas (1991). In 1999 he married Kirsten Mehr, a German national, by whom he has two more children, Victoria (born 2000) and Isabelle (born 2005).^[7]

Farage has also penned his own memoirs, entitled "Fighting Bull." It outlines the founding of UKIP and his personal and political life so far.

Political career[link]

Conservative Party[link]

Active in the Conservative Party from his school days, Farage left the party in 1992 when John Major's government signed the Treaty on European Union at Maastricht.

UKIP and the European Parliament[link]

Farage became a founding member of UKIP in 1993.

He was elected to the European Parliament in 1999 and re-elected in 2004 and 2009. Farage is presently the leader of the thirteen-member UKIP contingent in the European Parliament, and co-leader of the multinational eurosceptic group, Europe of Freedom and Democracy.

UKIP party leadership[link]

On 12 September 2006, Farage was elected leader of UKIP with 45% of the vote, 20% ahead of his nearest rival.^[8] He pledged to bring discipline to the party and to maximise UKIP's representation in local, parliamentary and other elections.^{[citation needed]} In a PM programme interview on BBC Radio 4 that day he pledged to end the public perception of UKIP as a single-issue party and to work with allied politicians in the Better Off Out campaign, committing himself not to stand against the MPs who have signed up to that campaign (ten in all at this moment).

At his maiden speech to the UKIP conference on 8 October 2006, he told delegates that the party was "at the centre-ground of British public opinion" and the "real voice of opposition". Farage said: "We've got three social democratic parties in Britain — Labour, Lib Dem and Conservative are virtually indistinguishable from each other on nearly all the main issues" and "you can't put a cigarette paper between them and that is why there are nine million people who don't vote now in general elections that did back in 1992."^[9]

At 10pm on 19 October 2006, Farage took part in a three-hour live interview and phone-in with James Whale on national radio station talkSPORT. Four days later, Whale announced on his show his intention to stand as UKIP's candidate in the 2008 London Mayoral Election. Farage said that Whale "not only has guts, but an understanding of what real people think". However Whale later decided not to stand and UKIP was represented by Gerard Batten.^[10] He stood again for UKIP leadership in 2010 after his successor Lord Pearson stood down.^[4] On the 5th November 2010 it was announced Farage had won the leadership contest.^[11]

Westminster elections[link]

Farage had unsuccessfully contested UK parliamentary elections for UKIP five times, both before and after his election as an MEP in 1999. Under the 2002 European Union decision to forbid MEPs from holding a dual mandate, if he was ever elected to the House of Commons, he would have to resign his seat as an MEP.

When he contested the Bromley & Chislehurst constituency in a May 2006 by-election, organised after the sitting MP representing it, eurosceptic Conservative Eric Forth, died, Farage came third, winning 8% of the vote, beating the Labour Party candidate. This was the second-best by-election result recorded by UKIP out of 25 results, and the first time since the Liverpool Walton by-election in 1991 that a party in government had been pushed into fourth place in a parliamentary by-election on mainland Britain.

2010 UK General election[link]

On 4 September 2009 Farage resigned as leader of UKIP to concentrate on his campaign to become Member of Parliament for Buckingham at Westminster in the 2010 general election.^[12] He later told Times journalist Camilla Long that UKIP internal fights took up too much time.^[13]

He stood against Buckingham MP John Bercow, the newly elected Speaker of the House of Commons, despite a convention that the speaker, as a political neutral, is not normally challenged in his or her bid for re-election by any of the major parties.^[14]

On 6 May, on the morning the polls opened in the election, just before eight o'clock Farage was involved in a light aircraft crash, suffering injuries described as non-life-threatening. A spokesperson told the BBC that "it was unlikely Mr Farage would be discharged from hospital today [6 May]^[15] Although his injuries were originally described as minor, his sternum and ribs were broken, and his lung punctured.^[16] The Air Accident Investigation Branch (AAIB) report said that the aeroplane was towing a banner, which caught in the tailplane, forcing the nose down.^[17]

Farage came third with 8,401 votes. Bercow was re-elected, and in second place with 10,331 votes was John Stevens, a former Conservative MEP who campaigned as an independent accompanied by "Flipper the Dolphin" (a reference to MPs flipping second homes).^[18]

On 1 December 2010, the pilot of the aircraft involved in the accident was charged with threatening to kill Farage. He was also charged with threatening to kill an AAIB official involved in the investigation into the accident.^[19] In April 2011, Justin Adams was found guilty of making death threats. The judge said the defendant was "clearly extremely disturbed" at the time the offences happened adding "He is a man who does need help. If I can find a way of giving him help I will."^[20]

Alternative Vote referendum, May 2011[link]

Farage declared himself personally in favour of the Alternative Vote system of May 2011, saying first-past-the-post is a "nightmare" for UKIP. However, the party's stance has to be decided by its central policy making committee.^[21]

May 2012 London Mayor & Local elections[link]

In a "bizarre cock-up," UKIP forgot to put their party name on their candidate's ballot paper for the London mayoral election, 2012^[22], Laurence Webb appearing as "A fresh choice for London." Farage admitted the mistake describing it as an internal error.^[22]
Interviewed by the following Sunday by Andrew Neil and asked about "the game plan", Farage welcomed the "average 13% vote" across the country, and stated that the party was preparing for County council in 2013, European elections in 2014 and a general election in 2015.^[23] The party was no longer just a protest vote, it would have a full manifesto with policies including selective schools, help to small businesses by "getting rid of excessive labour practices" and an energy policy not based on wind turbines.^[23] UKIP was here to stay ..frankly the Tory Eurosceptics were in the wrong party and would be better off joining UKIP. Asked what would happen to UKIP if the Tories made a Manifesto commitment to a European referendum, Farage said they had already failed to honour a "cast iron" commitment for a referendum on the Lisbon treaty.^[23]

Challenging Farange's viewpoint, Neil said UKIP aspired to come top of the European elections but whilst UKIP wanted to join the big time, they were still seen as "unprofessional, amateur and even unacceptable" after their press officer called Baroness Warsi "a bitch".^[23] Farage regretted "the wrong choice of words" but further described Warsi as "the lowest grade chairman the Tory party has ever had."^[23] Neil then mocked the so called internal error which had made Farage "a joke".^[23] "The blunt truth is" UKIP "didn't win any more seats, the performance in London was terrible and they were still a one man band."^[23] Farage conceded London was a failure but they had won council seats elsewhere. He invited Tories who couldn't stand Cameron to help him.^[23]

Controversies and whistleblowing[link]

Copyright infringement[link]

In 1999 the BBC spent four months filming a documentary about his European elections campaign but didn't show it. Farage, then head of UKIP's South East office, asked for a video and got friends to make illegal copies which were sold for £5 through the UKIP magazine. Surrey Trading Standards investigated and Farage has admitted the offence.^[24]

Expenses disclosure[link]

In May 2009, The Guardian reported that Farage had said in a speech to the Foreign Press Association that over ten years as a member of the European Parliament he received £2 million of taxpayers' money in staff, travel, and other expenses on top of his £64,000 a year salary.^[25]

The former Europe Minister, Denis MacShane, said that this showed that Farage was "happy to line his pockets with gold". Farage called this a "misrepresentation",^[26] pointing out that the money had been used to promote UKIP's message and staff salaries, not his own salary, but he welcomed the focus on the issue of MEP expenses, claiming that "[o]ver a five year term each and every one of Britain's 78 MEPs gets about £1 million. It is used to employ administrative staff, run their offices and to travel back and forth between their home, Brussels and Strasbourg."^[27]

Jacques Barrot[link]

On 18 November 2004, Farage announced in the European Parliament that Jacques Barrot, the French Commissioner designate, had been barred from elected office in France for 2 years, after being convicted in 2000 of embezzling £2 million from government funds and diverting it into the coffers of his party. He claimed that French President Jacques Chirac had granted Barrot amnesty. Although initial BBC reports claimed that, under French law, it was illegal even to mention the conviction,^[28] the prohibition in question only applies to French officials in the course of their duties.^[29] The president of the Parliament, Josep Borrell, enjoined him to retract his comments under threat of "legal consequences".^[30] However, the following day it was confirmed that Barrot had received an 8 month suspended jail sentence in the case, and that this had been quickly expunged by the amnesty decided by Chirac and his parliamentary majority. The Commission's president, Jose Manuel Barroso admitted that he had not known of Barrot's criminal record when appointing him as a Commission vice-president.^{[citation needed]} The Socialist and Liberal groups in the European Parliament then joined UKIP in demanding the resignation of Barrot for failing to disclose the conviction during his confirmation hearings.

José Manuel Barroso[link]

During the spring of 2005, Farage requested that the European Commission disclose where the individual Commissioners had spent their holidays. The Commission did not provide the information requested, on the basis that the Commissioners had a right of privacy. The German newspaper Die Welt reported that the President of the European Commission, José Manuel Barroso had spent a week on the yacht of the Greek shipping billionaire Spiro Latsis. It emerged soon afterwards that this had occurred a month before the Commission under Barroso's predecessor Romano Prodi approved 10.3 million euro of Greek state aid for Latsis' shipping company.^[31] It also became known that Peter Mandelson, then a member of the Commission, had accepted a trip to Jamaica from an unrevealed source.

Farage persuaded around 75 MEPs from across the political divide to back a motion of no confidence in Barroso, which would be sufficient to compel Barroso to appear before the European Parliament to be questioned on the issue.^[32] The motion was successfully tabled on 12 May 2005, and Barroso appeared before Parliament^[33] at a debate on 26 May 2005. The motion was heavily defeated. A Conservative MEP, Roger Helmer, was expelled from his group, the European People's Party - European Democrats (EPP-ED) in the middle of the debate by that group's leader Hans-Gert Poettering as a result of his support for Farage's motion.

Joseph Daul[link]

In January 2007, the French farmers' leader Joseph Daul was elected the new leader of the European People's Party–European Democrats (EPP-ED), the European Parliamentary grouping which then included the British Conservatives. The UK Independence Party almost immediately revealed that Daul had been under judicial investigation in France since 2004 as part of an inquiry into the alleged misuse of public funds worth €16 million (£10.6 million) by French farming unions."^[34] It was not suggested that Daul had personally benefited, but was accused of "complicity and concealment of the abuse of public funds." Daul accused Farage of publicising the investigation for political reasons and threatened to sue Farage, but did not do so though the court dropped all charges against him.

Prince Charles[link]

Prince Charles gave a speech to the European Parliament on 14 February 2008, in which he called for EU leadership in the war against climate change. During the standing ovation that followed, Farage was the only MEP to remain seated and went on to describe the Prince's advisers as "naïve and foolish at best."^[35] Farage continued: "How can somebody like Prince Charles be allowed to come to the European Parliament at this time to announce he thinks it should have more powers? It would have been better for the country he wants to rule one day if he had stayed home and tried to persuade Gordon Brown to give the people the promised referendum on the Treaty of Lisbon." The leader of the UK Labour Party's MEPs, Gary Titley, accused Farage of anti-Royalism. Titley said: "I was embarrassed and disgusted when the Leader of the UK Independence Party, Nigel Farage, remained firmly seated during the lengthy standing ovation Prince Charles received. I had not realised Mr Farage's blind adherence to right wing politics involved disloyalty and discourtesy to the Royal Family. He should be thoroughly ashamed of himself and should apologise to the British people he represents."^[35]

Herman Van Rompuy[link]