Flyboy Gary, in his state of intoxication, expresses his thoughts regarding YouTube's decision to discontinue video responses on September 12th. NOTE: This is just a skit. Alcohol intoxication (also known as drunkenness or inebriation) is a physiological state induced by the consumption of alcohol. Intoxication is the consequence of alcohol entering the bloodstream faster than it can be metabolized by the liver. Some effects of alcohol intoxication are central to alcohol's desirability as a beverage and its history as the world's most widespread recreational drug. Common effects are euphoria and lowered social inhibitions. Other effects are unpleasant or dangerous because alcohol affects many different areas of the body at once and may cause progressive, long-term harm when consumed in excess. Common symptoms of alcohol intoxication include slurred speech, euphoria, impaired balance, loss of muscle coordination (ataxia), flushed face, dehydration, vomiting, reddened eyes, reduced inhibitions, and erratic behavior. Sufficiently high levels of blood-borne alcohol will cause coma and death from the depressive effects of alcohol upon the central nervous system. "Acute alcohol poisoning" is a related medical term used to indicate a dangerously high concentration of alcohol in the blood, high enough to induce coma or respiratory depression. It is considered a medical emergency. The term is mostly used by health care providers. Toxicologists use the term "alcohol intoxication" to discriminate between alcohol and other toxins. In the past, alcohol was believed to be a non-specific pharmacological agent affecting many neurotransmitter systems in the brain. However, molecular pharmacology studies have shown that alcohol has only a few primary targets. In some systems these effects are facilitatory and in others inhibitory. Among the neurotransmitter systems with enhanced functions are: GABAA, 5-HT3 receptor agonism (responsible for GABAergic (GABAA receptor PAM), glycinergic, and cholinergic effects), nicotinic acetylcholine receptors. Among those that are inhibited are: NMDA, dihydropyridine-sensitive L-type Ca2+ channels and G-protein-activated inwardly rectifying K+ channels. The result of these direct effects is a wave of further indirect effects involving a variety of other neurotransmitter and neuropeptide systems, leading finally to the behavioural or symptomatic effects of alcohol intoxication. YouTube is a video-sharing website, created by three former PayPal employees in February 2005 and owned by Google since late 2006, on which users can upload, view and share videos. The company is based in San Bruno, California, and uses Adobe Flash Video and HTML5 technology to display a wide variety of user-generated video content, including movie clips, TV clips, and music videos, as well as amateur content such as video blogging, short original videos, and educational videos. Most of the content on YouTube has been uploaded by individuals, although media corporations including CBS, the BBC, Vevo, Hulu, and other organizations offer some of their material via the site, as part of the YouTube partnership program. Unregistered users can watch videos, while registered users can upload an unlimited number of videos. Videos considered to contain potentially offensive content are available only to registered users at least 18 years old. YouTube, LLC was bought by Google for US$1.65 billion in November 2006 and now operates as a Google subsidiary.

• published: 31 Aug 2013
• views: 11