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Etoxadrol (CL-1848C) is a dissociative anaesthetic drug that has been found to be an NMDA antagonist and produce similar effects to PCP in animals. Etoxadrol, along with another related drug dexoxadrol, were developed as analgesics for use in humans, but development was discontinued in the late '70s after patients reported side effects such as nightmares and hallucinations.

Phenicyclidine (PCP), tenocyclidine (TCP), etoxadrol and its precursor, dexoxadrol have related chemical structures. These drugs all act similarly on the nervous system, acting as dissociative hallucinogens (meaning that they interfere with normal sensory signals, replacing them with hallucinations of any sensory modality) with anesthetic and analgesic properties.

It is thought that these drugs’ phenyl and amine groups interact with the PCP binding site on the NMDA receptor. This explains how drugs with as diverse structures as etoxadrol/dexoxadrol, ketamine and PCP/TCP all induce similar effects on the nervous system.

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This page contains text from Wikipedia, the Free Encyclopedia - http://en.wikipedia.org/wiki/Etoxadrol

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