Armodafinil

Systematic (IUPAC) name
(–)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a602016
Pregnancy cat.	C
Legal status	Schedule IV (US) ℞ Prescription only
Routes	Oral
Pharmacokinetic data
Metabolism	Hepatic, including CYP3A4 and other pathways
Half-life	12-15 hrs
Excretion	Urine (as metabolites)
Identifiers
CAS number	112111-43-0 N
ATC code	N06BA07
PubChem	CID 9690109
ChemSpider	7962943 Y
UNII	V63XWA605I Y
KEGG	D03215 Y
ChEMBL	CHEMBL1201192 N
Chemical data
Formula	C15H15NO2S
Mol. mass	273.351
SMILES	eMolecules & PubChem
InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m1/s1 Y Key:YFGHCGITMMYXAQ-LJQANCHMSA-N Y
N (what is this?)  (verify)

Armodafinil (Nuvigil) is a stimulant-like drug produced by the pharmaceutical company Cephalon Inc., which was approved by the FDA on June 15, 2007.^[1][2] Armodafinil is an enantiopure drug consisting of just the active (−)-(R)-enantiomer of the racemic drug modafinil (Provigil).

Medical uses[link]

Sleep disorders[link]

Armodafinil is approved by the FDA for the treatment of narcolepsy and shift work sleep disorder, and as an adjunctive treatment for obstructive sleep apnea.^[3] For narcolepsy and obstructive sleep apnea, armodafinil is taken as a once daily 150 mg or 250 mg dose in the morning. For shift work sleep disorder, 150 mg of armodafinil are taken one hour prior to starting work. Slow dose titration is needed to mitigate some side effects.^[3]

Depression and schizophrenia[link]

Cephalon plans to conduct one or more Phase III clinical trials evaluating the use of Nuvigil as a adjunctive treatment for bipolar depression.^[4] In June, 2010, it was revealed that a phase II study of armodafinil as an adjunctive therapy in adults with schizophrenia had failed to meet the primary endpoints, and the clinical program was subsequently ceased.^[5]

Jet lag[link]

The drug was being considered for the first FDA-approved medicinally-specific drug for combating jet-lag.^[6] but on March 30, 2010, the FDA declined to approve use of Nuvigil to treat jet lag.^[7]

Adverse effects[link]

Armodafinil's common side effects include headache, nausea, insomnia, lack of appetite, dizziness, agitation, anxiety and high blood pressure.^[3]

See also[link]

• Modafinil
• Adrafinil
• Ampakines

References[link]

External links[link]

• NUVIGIL.com - official site
  • Medication Guide for Patients
  • Full Prescribing Information
• "A single dose of armodafinil significantly promotes vigilance 11 hours post-dose"

Top Quality was an American rapper formally signed to RCA Records in the early 1990s.

After appearing in The Source magazine's Unsigned Hype, a column dedicated to finding unsigned talent, Top Quality eventually caught the eye of EPMD's Parrish "PMD" Smith, who made him a member of the rap collective Hit Squad and was subsequently signed a deal with RCA Records. His debut album, Magnum Opus was released in November 1993 and was executively produced by Smith himself. The album, however, was a commercial failure. Unlike other Hit Squad releases at the time, Magnum Opus failed to sell many copies and peaked at only 95 on the Billboard R&B charts.^[1][2]

After being released from RCA, Top Quality appeared on PMD's Shade Business in 1994 and 3rd Eye's Planets in 1998, but he has not been heard of since.

Discography[link]

References[link]