Tandamine

Tandamine
Systematic (IUPAC) name
	2-(9-ethyl-1-methyl-3,4-dihydrothiopyrano[3,4-b]indol-1-yl)-N,N-dimethylethanamine
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	42408-80-0
ATC code	None
PubChem	CID 39187
UNII	7516K9UGUG
Chemical data
Formula	C18H26N2S
Mol. mass	302.476 g/mol
	SMILES CCn3c1ccccc1c2CCSC(C)(CCN(C)C)c23;
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Tandamine is a selective norepinephrine reuptake inhibitor with a tricyclic structure.^[1]^[2]^[3] It was developed in the 1970s as an antidepressant but was never commercialized.^[1]^[2]^[3] Tandamine is analogous to pirandamine, which, instead, acts as a selective serotonin reuptake inhibitor (SSRI).^[4]^[5]

[edit] See also

^ ^a ^b Lippmann W, Pugsley TA (May 1976). "The effects of tandamine, a new potential antidepressant agent, on biogenic amine uptake mechanisms and related activities". Biochemical Pharmacology 25 (10): 1179–86. doi:10.1016/0006-2952(76)90366-X. PMID 1084746.
^ ^a ^b Ehsanullah RS, Ghose K, Kirby MJ, Turner P, Witts D (March 1977). "Clinical pharmacological studies of tandamine, a potential antidepressive drug". Psychopharmacology 52 (1): 73–7. doi:10.1007/BF00426603. PMID 403562.
^ ^a ^b Pugsley TA, Lippmann W (September 1979). "Effect of acute and chronic treatment of tandamine, a new heterocyclic antidepressant, on biogenic amine metabolism and related activities". Naunyn-Schmiedeberg's Archives of Pharmacology 308 (3): 239–47. doi:10.1007/BF00501388. PMID 503251.
^ Pugsley T, Lippmann W (May 1976). "Effects of tandamine and pirandamine, new potential antidepressants, on the brain uptake of norepinephrine and 5-hydroxytryptamine and related activities". Psychopharmacology 47 (1): 33–41. doi:10.1007/BF00428698. PMID 1085452.
^ Lippmann W, Seethaler K (April 1977). "Effects of tandamine and pirandamine, selective blockers of biogenic amine uptake mechanisms, on gastric acid secretion and ulcer formation in the rat". Life Sciences 20 (8): 1393–400. doi:10.1016/0024-3205(77)90367-8. PMID 853871.

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