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Idalopirdine granted Fast Track Designation by U.S. Food and Drug Administration (FDA) (H Lundbeck A/S)

Edit Public Technologies 07 Jul 2016
(Source. H Lundbeck A/S). Designation provides the opportunity for more frequent interactions with FDA during clinical development and potential eligibility for priority review. Valby, 2016-07-07 15.00 CEST (GLOBE NEWSWIRE) -- H ... Through 5-HT6 receptors expressed on glutamatergic neurons and GABAergic interneurons, idalopirdine is believed to modulate the balance between excitation (glutamate) and inhibition (GABA) in the brain[iii] ... H ... H....

Investigating new epilepsy treatments (Cardiff University)

Edit Public Technologies 16 Jun 2016
With TLE a loss/dysfunction of interneurons in the hippocampus of the brain is one of the earliest changes. In theory, it should be possible to address this balance by replacing these lost/damaged interneurons with new ones, and experimental attempts to do this have been promising ... the survival, development and integration of the new interneurons....

The Use of Stem Cell Therapy in Epilepsy (Epilepsy Foundation of America)

Edit Public Technologies 08 Jun 2016
(Source. Epilepsy Foundation of America). Listen as Basic Science Editor Sloka Iyengar PhD talks about the use of stem cell therapy in epilepsy ... Transplantation of interneurons The brain has neurons that can excite other cells and others that inhibit or stop action of cells ... Specific groups of inhibitory neurons (also called interneurons) are formed from a specific area of the brain (called the medial ganglionic eminences) ... (noodl....

Striatal cholinergic interneurons and Parkinson{#x2019}s [Neuroscience]>

Edit PNAS 31 May 2016
Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson’s disease (PD). In PD, motor deficits correlate with the emergence of exaggerated beta frequency (15–30 Hz) oscillations throughout the CBT network. However, little is... ....

Differential Recruitment of Dentate Gyrus Interneuron Types by Commissural Versus Perforant Pathways

Edit Topix 17 May 2016
Address correspondence to Ming-Hong Tai, Institute of Biomedical Sciences, National Sun Yat-Sen University, 70, Lienhai Road, Kaohsiung 804, Taiwan. Email. ; Cheng-Chang Lien, Institute of Neuroscience, National Yang-Ming University, 155, Section 2, Li-Nong Street, Taipei 112, Taiwan ... ....

Early life stress accelerates maturation of key brain region in male mice (Brown University)

Edit Public Technologies 10 May 2016
Based upon measures of gene expression and counting cells, the team saw that parvalbumin interneurons developed about a week early, attaining an abundance by day 21 in ELS mice that was not seen in control mice until day 28 ... the early abundance of parvalbumin interneurons), measuring whether maturation is accelerated or delayed in other areas in the ......

DA: Con man drugged, robbed gay men

Edit Boston Herald 10 May 2016
An accused Norwood con man who targeted, drugged and robbed gay men at their homes — and then adorned his own place with the stolen loot — has been indicted on a slew of charges stemming from his shady hookups, according to authorities ... In one case, the victim awoke to find his hands tied behind him ... In 1996, he pleaded guilty to stealing at least $6,792.41 from his former employer, Interneuron Pharmaceuticals ... Conley said. ....

Title V Grant Work Celebrated With Two Days Of Events At Hostos (CUNY - The City University of New York)

Edit Public Technologies 28 Apr 2016
(Source. CUNY - The City University of New York). Hostos Community College celebrated two years of the Title V grant, showcasing work produced by faculty, staff and students. The Title V grant was awarded to Hostos Community College in 2014 by the U.S. Department of Education ... Students ... Brian Gallego - 'Possible Alterations in Parvalbumin Immunopositive Interneurons in Layers 3 and 5 in Area 9 of the Prefrontal Cortex in Schizophrenia'....

Study reveals why older adults struggle to adapt to new environments

Edit Indian Express 27 Apr 2016
A study has revealed that older adults often seem confused in new environments due to deterioration of a brain circuit monitoring goal-directed learning. (Source ... Read More ... Further, this decline in behavioural flexibility was also accompanied by the deterioration of a specific pathway in the brain — called the parafascicular-to-cholinergic interneuron pathway (PF-to-CIN) — which resulted in faulty activation of striatal neurons....

Karyopharm Presents Data Demonstrating the Potential of Nuclear Export Protein Exportin 1 (XPO1) Inhibition in the Treatment of Traumatic Brain Injury (Karyopharm Therapeutics Inc)

Edit Public Technologies 20 Apr 2016
In an oral and poster presentation titled 'Using the Selective Inhibitor of Nuclear Export (SINE) Compound KPT-350 to Reduce Cortical Circuit Hyperexcitability and Interneuron Cell Loss in the Controlled Cortical Impact (CCI) Model of Traumatic Brain Injury (TBI),' Karyopharm researchers and collaborators presented data evaluating the effects of ......

Researchers Find Possible Treatment for Suppressed Immunity from Spine Injuries (Cincinnati Children's Hospital Medical Center)

Edit Public Technologies 19 Apr 2016
(Source. Cincinnati Children's Hospital Medical Center). Monday, April 18, 2016 ... Because of this, abnormal spinal interneurons are activated by the bladder and/or bowel ... In the instance of mouse high spinal cord injury models, the researchers used chemogenetics to silence signaling transmissions from newly forming interneurons that trigger the immune suppression reflex ... Funding support for the study came in part from ... Original Document....

Sweet tooth? Flies have it too—and new research explains how they know what to eat and when to stop (The Rockefeller University)

Edit Public Technologies 31 Mar 2016
(Source. The Rockefeller University). Bottoms up. The researchers filmed hungry flies drinking a drop of sugar solution (blue circles in the top panel) and simultaneously monitored the activity of their IN1 cells before, during, and after the drink was consumed (bottom panels) ... Dinner time ... 'These 12 interneurons help the brain identify what the flies are eating, and help regulate whether to continue or stop,' says Yapici ... (noodl....

March 10, 2016 Announcements (University of Louisville)

Edit Public Technologies 19 Mar 2016
(Source. University of Louisville). Want to know more about what is going on at UofL? Visit UofL Today online for articles, videos, photos, campus-submitted announcements and the UofL event calendar. Want to submit an announcement? Click here. =============. Here's what was posted to UofL Today on Wednesday, March 9, 2016 ... (Ch ... He will speak on, 'Mechanisms Regulating the Differentiation and Maturation of Distinct Interneuron Subgroups' ... Dr....
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