Frans De Mulder (17 December 1937 in Kruishoutem – 5 March 2001 in Deinze) was a professional road racing cyclist from Belgium between 1958 and 1963.
De Mulder is most famous for winning the overall title and four stages the 1960 Vuelta a España. He bested fellow countryman Armand Desmet and Spaniard Miguel Pacheco across 3566 km in 17 stages.