1:53
Mark Vonitzstein discusses Griffith University's groundbreaking Institute for Glycomics
Mark Vonitzstein discusses Griffith University's groundbreaking Institute for Glycomics
Mark Vonitzstein talks about Griffith's Institute for Glycomics and it's groundbreaking research to combat childhood diseases of the twenty-first century. If you don't qualify for direct entry to Griffith University, why not consider a Diploma of Biosciences at Queensland Insitute of Business and Technology (QIBT)? Learn more at qibt.qld.edu.au
2:16
NRPGM Core facilities introduction - D2Core Facilities for Proteomics and Glycomics
NRPGM Core facilities introduction - D2Core Facilities for Proteomics and Glycomics
TheCore Facilities of NRPGM were set up based on the concept of resource integration and management centralization. The objective is to establish and maintain nationwide facilities to support basic research in the field of genomic medicine, providing high-priced, high-throughput, and state-of-the-art instruments, along with analytical and consulting services. The Cores also aim at developing multi-disciplinary technologies, encouraging collaborative research projects. In addition, the Cores take the responsibilities of propagating the novel technologies and educating nationwide researchers, through which the standard of research in genomic medicine will be increased. National Core Facilities is opened for use by researchers from academic and industrial institutions. The Core Facilities cover five major fields:A. Animal Models, Phenotyping, and Imaging Facilities for Diseases, B. Clinical Sample Banks for Genomics, C. Facilities for Basic Genomics, D. Facilities for Proteomics and Structural Genomics, and E. Facilities for Bioinformatics Each core performs five major activities: Service, Technological / R&D, Collaborative Research, Education, and Dissemination. D2Core Facilities for Proteomics and Glycomics proteome.sinica.edu.tw
3:04
Glycans: What Makes Them So Special?
Glycans: What Makes Them So Special?
Dr. David F. Smith of Emory University talks about glycans, complex carbohydrates or glycans in the human body that are made of many individual sugar molecules and occur in glycoproteins, glycolipids, and other glycoconjugates. Glycans on the surfaces of human cells are bound by a huge assortment of carbohydrate binding proteins and are also bound by pathogens, including viruses and bacteria. Although the vast numbers of these interactions with the human glycome are important in virtually all aspects of human biology and disease, they are not well understood. Related Information NIH Awards EUREKA Grant to Emory Biochemists for Innovative Research in Glycomics Press Release, 10/10/08 whsc.emory.edu Emory Receives Grand Challenges Explorations Grant for Innovative Global Health Research Press Release, 5/4/2008 whsc.emory.edu Through the Looking Glass Feature Article, Momentum Magazine, Summer 2007 whsc.emory.edu
5:55
Big Brains Are Overrated
Big Brains Are Overrated
In the September issue of The Scientist, Karen Hopkin profiled glycomics expert Ajit Varki.
0:32
Griffith Professor Michael Good on finding a cure for malaria
Griffith Professor Michael Good on finding a cure for malaria
Lawrence Leung talks to Griffith Professor Michael Good on finding a cure for malaria.
2:47
Glycans: Where Are They and What Do They Do?
Glycans: Where Are They and What Do They Do?
Dr. David F. Smith of Emory University talks about glycans, complex carbohydrates or glycans in the human body that are made of many individual sugar molecules and occur in glycoproteins, glycolipids, and other glycoconjugates. Glycans on the surfaces of human cells are bound by a huge assortment of carbohydrate binding proteins and are also bound by pathogens, including viruses and bacteria. Although the vast numbers of these interactions with the human glycome are important in virtually all aspects of human biology and disease, they are not well understood. Related Information NIH Awards EUREKA Grant to Emory Biochemists for Innovative Research in Glycomics Press Release, 10/10/08 whsc.emory.edu Emory Receives Grand Challenges Explorations Grant for Innovative Global Health Research Press Release, 5/4/2008 whsc.emory.edu Through the Looking Glass Feature Article, Momentum Magazine, Summer 2007 whsc.emory.edu
1:13
NRPGM Core facilities introduction - core D group
NRPGM Core facilities introduction - core D group
TheCore Facilities of NRPGM were set up based on the concept of resource integration and management centralization. The objective is to establish and maintain nationwide facilities to support basic research in the field of genomic medicine, providing high-priced, high-throughput, and state-of-the-art instruments, along with analytical and consulting services. The Cores also aim at developing multi-disciplinary technologies, encouraging collaborative research projects. In addition, the Cores take the responsibilities of propagating the novel technologies and educating nationwide researchers, through which the standard of research in genomic medicine will be increased. National Core Facilities is opened for use by researchers from academic and industrial institutions. The Core Facilities cover five major fields:A. Animal Models, Phenotyping, and Imaging Facilities for Diseases, B. Clinical Sample Banks for Genomics, C. Facilities for Basic Genomics, D. Facilities for Proteomics and Structural Genomics, and E. Facilities for Bioinformatics Each core performs five major activities: Service, Technological / R&D, Collaborative Research, Education, and Dissemination. D2Core Facilities for Proteomics and Glycomics, D3Core facility for protein production and X-ray structural analysis, D4The Synchrotron Radiation Protein Crystallography Facility, D5High-Field Nuclear Magnetic Resonance Center
2:03
NRPGM Core facilities introduction - D5High-Field Nuclear Magnetic Resonance Center
NRPGM Core facilities introduction - D5High-Field Nuclear Magnetic Resonance Center
TheCore Facilities of NRPGM were set up based on the concept of resource integration and management centralization. The objective is to establish and maintain nationwide facilities to support basic research in the field of genomic medicine, providing high-priced, high-throughput, and state-of-the-art instruments, along with analytical and consulting services. The Cores also aim at developing multi-disciplinary technologies, encouraging collaborative research projects. In addition, the Cores take the responsibilities of propagating the novel technologies and educating nationwide researchers, through which the standard of research in genomic medicine will be increased. National Core Facilities is opened for use by researchers from academic and industrial institutions. The Core Facilities cover five major fields:A. Animal Models, Phenotyping, and Imaging Facilities for Diseases, B. Clinical Sample Banks for Genomics, C. Facilities for Basic Genomics, D. Facilities for Proteomics and Structural Genomics, and E. Facilities for Bioinformatics Each core performs five major activities: Service, Technological / R&D, Collaborative Research, Education, and Dissemination. D5High-Field Nuclear Magnetic Resonance Center www.nmr.sinica.edu.tw
3:19
NRPGM Core facilities - D3Core facility protein production and X-ray structural analysis
NRPGM Core facilities - D3Core facility protein production and X-ray structural analysis
TheCore Facilities of NRPGM were set up based on the concept of resource integration and management centralization. The objective is to establish and maintain nationwide facilities to support basic research in the field of genomic medicine, providing high-priced, high-throughput, and state-of-the-art instruments, along with analytical and consulting services. The Cores also aim at developing multi-disciplinary technologies, encouraging collaborative research projects. In addition, the Cores take the responsibilities of propagating the novel technologies and educating nationwide researchers, through which the standard of research in genomic medicine will be increased. National Core Facilities is opened for use by researchers from academic and industrial institutions. The Core Facilities cover five major fields:A. Animal Models, Phenotyping, and Imaging Facilities for Diseases, B. Clinical Sample Banks for Genomics, C. Facilities for Basic Genomics, D. Facilities for Proteomics and Structural Genomics, and E. Facilities for Bioinformatics Each core performs five major activities: Service, Technological / R&D, Collaborative Research, Education, and Dissemination. D3Core facility for protein production and X-ray structural analysis proteome.sinica.edu.tw
2:21
Angie Law Interview
Angie Law Interview
Angie and Larry Law came to St. Louis in July 2011 and did their glycobiology training for medical professionals. Most of us were normal people but we had several Doctors and Nurses in attendance. An excellent job was done by Angie and Larry and their tag team style of teaching. Larry was shy and did not want to do an interview. He is an excellent teacher, though. He retired from doing that full time and now works with Angie and trains doctors and the general public about glycomics. angiesoption.com Angie is now excited about the Win Win Win program for raising money for non profits like schools churches, ball teams, or clubs while combating global malnutrition by feeding thousands of undernourished children all over the world. She gives her contact info if you have questions. You get a bargain price on her DVD Glycobiology class if you watch this video. Angie says: "Larry and I do not pretend to have medical degrees or backgrounds in the field of glycobiology. What we have done is simply fit a need. There wasn't anyone teaching a class which overviews this science (as a introduction to it) and gives an opportunity for healthcare professionals to continue to investigate, if they choose, by attending accredited courses through Proevity which are sanctioned by the AMA. We make that very clear in our introduction and our hope and desire is our class will give healthcare professionals the opportunity to even KNOW there is such an option. We also invite the public to attend as <b>...</b>
2:03
NRPGM Core facilities introduction - D4The Synchrotron Radiation Protein Crystallography Facil
NRPGM Core facilities introduction - D4The Synchrotron Radiation Protein Crystallography Facil
TheCore Facilities of NRPGM were set up based on the concept of resource integration and management centralization. The objective is to establish and maintain nationwide facilities to support basic research in the field of genomic medicine, providing high-priced, high-throughput, and state-of-the-art instruments, along with analytical and consulting services. The Cores also aim at developing multi-disciplinary technologies, encouraging collaborative research projects. In addition, the Cores take the responsibilities of propagating the novel technologies and educating nationwide researchers, through which the standard of research in genomic medicine will be increased. National Core Facilities is opened for use by researchers from academic and industrial institutions. The Core Facilities cover five major fields:A. Animal Models, Phenotyping, and Imaging Facilities for Diseases, B. Clinical Sample Banks for Genomics, C. Facilities for Basic Genomics, D. Facilities for Proteomics and Structural Genomics, and E. Facilities for Bioinformatics Each core performs five major activities: Service, Technological / R&D, Collaborative Research, Education, and Dissemination. D4The Synchrotron Radiation Protein Crystallography Facility bionsrrc.nsrrc.org.tw
0:28
ODANGO Viewer -demo movie-
ODANGO Viewer -demo movie-
ODANGO Viewer DEMO movie www.sci.cs.is.nagoya-u.ac.jp ODANGO is an interactive CFG viewer. CFG data are very valuable in biology, but each is independent. Therefore it is not easily to discover new wisdom. You can look at all data of CFG as one picture and actually feel the relation structure by touching the picture.
54:25
Bittersweet Roles of O-GlcNAcylation in Diabetes, Alzheimer's Disease and Cancer
Bittersweet Roles of O-GlcNAcylation in Diabetes, Alzheimer's Disease and Cancer
Air date: Wednesday, December 07, 2011, 3:00:00 PM Timedisplayed is Eastern Time, Washington DC Local Category: Wednesday Afternoon Lectures Description: O-GlcNAcylation, the cycling of a N-acetylglucosamine monosaccharide on Ser(Thr) residues of nuclear and cytoplasmic proteins, serves as a nutrient/stress sensor to regulate signaling, transcription and cellular metabolism. Recent phospho- and glycomic approaches have shown that an increase in global O-GlcNAcylation affects phospho-site occupancy at nearly every actively cycling site. A chemico-enzymatic photochemical enrichment method, combined with ETD-mass spectrometry allows detection of O-GlcNAc site occupancy at a level of sensitivity comparable to that possible for phosphorylation. These analyses show that crosstalk between site-specific phosphorylation and O-GlcNAcylation is extensive. Many kinases are both modified and regulated by O-GlcNAcylation. The major sensor of cellular energy state, AMPK is O-GlcNAcylated. AMPK and O-GlcNAc transferase share many substrates and the two systems directly interact. Major signaling cascades (eg. CDK1, aurora kinase, polo kinase) that regulate cell division are strikingly affected by a small change in O-GlcNAcylation. O-GlcNAc is part of the histone code, but many of the O-GlcNAc residues are at sites interacting with DNA in the nucleosome, not in the histone tails. Multiple core ribosome proteins are modified by O-GlcNAc, which plays a role in ribosome biogenesis and <b>...</b>
68:04
Proteins as Chameleons: The Good, the Bad and the Ugly
Proteins as Chameleons: The Good, the Bad and the Ugly
Air date: Wednesday, April 14, 2010, 3:00:00 PM Timedisplayed is Eastern Time, Washington DC Local Category: Wednesday Afternoon Lectures Description: Proteins are not merely the products from gene translation, but may undergo extensive co- and post-translational modifications that result in significant divergence from the plan of the template. And some are not even template-driven! Full understanding of normal and aberrant protein structure/function relationships requires not only identification and quantification of proteins that indicate which cellular pathways are affected under the conditions chosen for study, but also characterization of post-translational modifications (PTMs) to these proteins [1]. Antibody-based pull-down methods retrieve molecular complexes whose composition can vary depending on the presence of sequence elements or PTMs of key proteins [2]. Alternatively, chemical modifications to specific amino acids (eg, ICAT, fluorolabels) or isolation methods that are based on chemical interactions (eg, with phosphate groups) enable the enrichment of proteins/peptides that bear specific markers for processes such as oxidative stress, protein misfolding, or cancer [1-6]. We have developed strategies for separation of intact proteins or peptides and for determination of their complete amino acid sequences and the identification and site-specific localization of PTMs. If the PTMs are labile under routine MS conditions (eg, phosphorylation, sulfonation <b>...</b>
9:44
Stem Cell Research
Stem Cell Research
One of my first major productions. I did this for Chemestry back in Highschool, 2002. Probably one of my best videos, dispite my lack of skills, a decent camera, or decent editing hardware...
47:44
Carolyn Bertozzi (UC Berkeley) Part 1 Chemical Glycobiology
Carolyn Bertozzi (UC Berkeley) Part 1 Chemical Glycobiology
Part 1 A large part of an organism's complexity is not encoded by its genome but results from post-translational modification. Glycosylation, or the addition of sugar molecules to a protein is an example of such a modification. These sugars, or glycans, are often complex, branched molecules specific to particular cells. Cell surface glycans determine human blood types, allow viral infections and play a key role in tissue inflammation. See more at www.ibioseminars.org
