Zicronapine

Zicronapine

Systematic (IUPAC) name
4-[(1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl]-1,2,2-trimethylpiperazine
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	170381-16-5
ATC code	?
Chemical data
Formula	C22H27ClN2
Mol. mass	354.9 g/mol
SMILES C1([C@H]2C(=CC=C3)C=C3)C([C@@H](C2)[N@@](CC(C)(C)N2C)CC2)=CC(=CC=1)Cl

Zicronapine (zye-kron-a-peen, previously known as Lu 31-130) is an atypical antipsychotic medication currently under development by H. Lundbeck A/S. In phase II studies zicronapine did show statistical significant separation from placebo and very convincing efficacy and safety data when compared to olanzapine.

Zicronapine exhibits monoaminergic activity and has a multi-receptorial profile. In vitro and in vivo it has shown potent antagonistic effects at dopamine D₁, D₂ and serotonin 5HT_2A receptors.