Setoperone
| Setoperone | |
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6-[2-[4-[(4-Fluorophenyl)-oxomethyl]-1-piperidinyl]ethyl]-7-methyl-2,3-dihydrothiazolo[2,3-b]pyrimidin-5-one |
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| Identifiers | |
| CAS number | 86487-64-1 |
| PubChem | 68604 |
| ChemSpider | 61870 |
| KEGG | D02686  |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C21H24FN3O2S |
| Molar mass | 401.50 g/mol |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Setoperone is a compound that is a ligand to the 5-HT2A receptor. It can be radiolabeled with the radioisotope fluorine-18 and used as a radioligand with positron emission tomography (PET). Several research studies have used the radiolabeled setoperone in neuroimaging for the studying neuropsychiatric disorders, such as depression[1] or schizophrenia.[2]
References [edit]
- ^ Jeffrey H. Meyer, Shitij Kapur, Sylvain Houle, Jean DaSilva, Beata Owczarek, Gregory M. Brown, Alan A. Wilson and Sidney H. Kennedy (July 1, 1999). "Prefrontal Cortex 5-HT2 Receptors in Depression: An [18F]Setoperone PET Imaging Study". American Journal of Psychiatry 156 (7): 1029–1034. PMID 10401447.
- ^ Ralph Lewis, Shitij Kapur, Corey Jones, Jean DaSilva, Gregory M. Brown, Alan A. Wilson, Sylvain Houle and Robert B. Zipursky (January 1, 1999). "Serotonin 5-HT2 Receptors in Schizophrenia: A PET Study Using [18F]Setoperone in Neuroleptic-Naive Patients and Normal Subjects". American Journal of Psychiatry 156 (1): 72–78. PMID 9892300.
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