Fluotracen

Fluotracen
Systematic (IUPAC) name
	N,N-dimethyl-3-[10-methyl-2-(trifluoromethyl)-9,10-dihydroanthracen-9-yl]propan-1-amine
Clinical data
Pregnancy cat.	?
Legal status	Uncontrolled
Routes	Oral
Identifiers
CAS number	35764-73-9; 57363-14-1 (HCl)
ATC code	None
PubChem	CID 42291
ChemSpider	38565
UNII	3026WKR55S
Chemical data
Formula	C21H24F3N
Mol. mass	347.42 g/mol
	SMILES FC(F)(F)c1ccc3c(c1)C(c2ccccc2C3C)CCCN(C)C;

Fluotracen (SKF-28,175) is a tricyclic drug which possesses dual antidepressant and antipsychotic activity.^[1]^[2]^[3] This profile of effects is similar to that of related agents like amoxapine, loxapine, and trimipramine which may also be used in the treatment of both depression and psychosis.^[1] It was believed that such duality would be advantageous in the treatment of schizophrenia, as depression is often comorbid with the disorder (i.e., negative symptoms), and usual antipsychotics often worsen such symptoms.^[1] In any case, however, fluotracen was never marketed.^[3]

References [edit]

^ ^a ^b ^c Annual Reports in Medicinal Chemistry: v. 14. Academic Press Inc.,U.S. 1979. ISBN 0-12-040514-8.
^ Fowler PJ, Zirkle CL, Macko E, et al. (1977). "Fluotracen: a tricyclic compound with the combined properties of antidepressants and antipsychotics in animals". Arzneimittel-Forschung 27 (8): 1589–95. PMID 410422.
^ ^a ^b David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.

[isbn0-12-040514-8-1] Annual Reports in Medicinal Chemistry: v. 14. Academic Press Inc.,U.S. 1979. ISBN 0-12-040514-8.

[pmid410422-2] Fowler PJ, Zirkle CL, Macko E, et al. (1977). "Fluotracen: a tricyclic compound with the combined properties of antidepressants and antipsychotics in animals". Arzneimittel-Forschung 27 (8): 1589–95. PMID 410422.

[isbn0-412-46630-9-3] David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.

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Fluotracen

See also [edit]

References [edit]

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