Ethinamate
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Systematic (IUPAC) name | |
(1-ethynylcyclohexyl)carbamate | |
Clinical data | |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
Pregnancy cat. | ? |
Legal status | ℞ Prescription only |
Routes | Oral |
Identifiers | |
CAS number | 126-52-3 |
ATC code | None |
PubChem | CID 3284 |
DrugBank | DB01031 |
ChemSpider | 3169 ![]() |
UNII | IAN371PP48 ![]() |
KEGG | D00703 ![]() |
ChEBI | CHEBI:4884 ![]() |
ChEMBL | CHEMBL1576 ![]() |
Chemical data | |
Formula | C9H13NO2 |
Mol. mass | 167.205 g/mol |
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Ethinamate (Valamin, Valmid) is a short-acting carbamate-derivative sedative-hypnotic medication used to treat insomnia. Regular use leads to drug tolerance, and it is usually not effective for more than 7 days. Prolonged use can lead to dependency.
Ethinamate has been replaced by other medicines (particularly benzodiazepines), and it is not available in the Netherlands, the United States or Canada.
Chemistry [edit]
Ethinamate (1-ethynylcyclohexanone carbamate) is synthesized by combining acetylene with cyclohexanone and then transforming the resulting carbinol into a carbamate by the subsequent reaction with phosgene, and later with ammonia. Some lithium metal or similar is used to make the acetylene react with the cyclohexanone in the first step.[1][2]
References [edit]
- ^ H. Pfeiffer, K. Junkman, U.S. Patent 2,816,910 (1957)
- ^ H. Emde, W. Grimme, DE 1021843 (1953)
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