search tools

Karyopharm Presents Preliminary STOMP Phase 1b Clinical Data at 2016 European Hematology Association Annual Meeting (Karyopharm Therapeutics Inc)

Edit Public Technologies 10 Jun 2016
(Source. Karyopharm Therapeutics Inc). - Updated Clinical Data Shows High Response Rates When Selinexor Is Combined with Standard of Care Agents in Heavily Pretreated Patients with Multiple Myeloma - ... Dr ... SdB - All ... SdB -. Proteasome. Inhibitor ... Ten of the 16 evaluable patients in the SdB combination arm had MM previously refractory to a proteasome inhibitor and several had high risk haplotypes including deletion of chromosome 17p ... Contact....

Taiwan Researchers Identify the Interactions between CHRNA7 polymorphisms, Apolipoprotein E ε4 status and Smoking on Dementia Risk (ASPH - Association of Schools of Public Health)

Edit Public Technologies 09 Jun 2016
(Source. ASPH - Association of Schools of Public Health) ... Nine CHRNA7 haplotype-tagging single nucleotide polymorphisms representative for Taiwanese were genotyped. Among APOE ε4 non-carriers, rs7179008 variant and GT haplotype in CHRNA7 block4 was significantly associated with decreased LOAD risk after correction for multiple tests. A significant interaction was found between rs7179008, GT haplotype in block4 and APOE ε4 on LOAD risk....

Some Humans Migrated Back To Africa 45,000 Years Ago

Edit IFL Science 27 May 2016
Our species evolved in Africa ... The findings were published in Scientific Reports last week ... Radiocarbon dating puts the skull at 35,000 years old ... This newly identified basal lineage has now disappeared, but haplotypes derived from it can be found today – mostly in northwestern African populations ... Derived U6 haplotypes now found in Europe were likely due to much more recent gene flow from Africa ... ....

from wild beast to man's best friend

Edit The National 18 May 2016
Genetic analysis of camel bones from Al Sufouh and other sites in the UAE forms a major part of a new study, which suggests that south-east Arabia, now known as the UAE and Oman, was probably where the dromedary was domesticated ... These salty plants were, along with dry grass, just what wild camels liked to eat ... The samples contained some haplotypes, or sets of genes inherited from a single parent, also found in modern camels ... why here?....

Second gene modifies effect of mutation in dog model of ALS (Uppsala universitet)

Edit Public Technologies 17 May 2016
(Source. Uppsala universitet). 2016-05-17. Canine Degenerative Myelopathy (DM) is a neurodegenerative disease in dogs with similarities to ALS in humans ... The study is published in PNAS this week ... Genome-wide association analysis comparing affected and unaffected PWC with the SOD1 mutation identified a haplotype within the gene 'SP110 nuclear body protein' that was associated with increased risk of developing DM and early age of onset....

Second gene modifies effect of mutation in DM, a dog model of ALS (Uppsala universitet)

Edit Public Technologies 17 May 2016
(Source. Uppsala universitet). Press release. 2016-05-16. Canine Degenerative Myelopathy (DM) is a neurodegenerative disease in dogs with similarities to ALS in humans ... Genome-wide association analysis comparing affected and unaffected PWC with the SOD1 mutation identified a haplotype within the gene 'SP110 nuclear body protein' that was associated with increased risk of developing DM and early age of onset ... Anneli Waara ... (noodl. 33598117) ....

Why The Eastern Coyote Should Be A Separate Species: The “Coywolf"

Edit IFL Science 13 May 2016
There is considerable debate and disagreement among scientists over what to call a canid inhabiting the northeastern United States ... The eastern coyote/coywolf in a nutshell ... This naming effectively discounts that, for example, one-third of the population’s mitochondrial DNA (C1 haplotype) is derived from the eastern wolf and another one-third (C9 haplotype) is not found in most nonhybridized western coyote populations but is ... ....

Thermo Fisher Scientific Introduces Precision ID NGS System for Forensic Analysis (Thermo Fisher Scientific Inc)

Edit Public Technologies 10 May 2016
(Source. Thermo Fisher Scientific Inc) ... The Applied Biosystems Precision ID NGS System for human identification is designed to effectively retrieve more information from degraded or limited DNA samples ... This is a particular challenge with samples from ancient bones or burnt remains ... 'Next-generation sequencing now makes this possible, and enables forensic scientists to better define haplotype classifications.' ... (noodl. 33474015) ....

Causes of dog’s diabetes are out of an owner’s control

Edit Palm Beach Post 20 Mar 2016
Question. Our special little mix-breed dog is only 4 years old, and he has been very healthy. He had a full checkup with blood tests four months ago, and our vet said everything was perfect. Then a few weeks ago he started drinking a lot more water and having to go outside a lot. I brought him to the vet, and he had lost weight ... Answer ... 1 ... 2 ... Certain breeds may have the DLA haplotype that makes them more susceptible to becoming diabetic ... 3 ... 4....

Lupus study shows precision medicine’s potential to define the genetics of autoimmune disease (The University of Texas Southwestern Medical Center at Dallas)

Edit Public Technologies 18 Mar 2016
They found that SLE risk is associated with specific clusters of DNA variations, commonly called haplotypes, and that some haplotypes increased the risk for SLE while others provided protection from SLE ... They discovered that the variants and haplotypes were distributed across subpopulations worldwide....

10x Genomics Completes $55 Million Series C Financing (Paladin Capital Group)

Edit Public Technologies 17 Mar 2016
10x Genomics' platform complements and upgrades existing sequencers, delivering new contextual information, including haplotyping, structural variation and de novo assembly, while easily integrating into existing lab infrastructure ... haplotypes, and other valuable genomic information while using existing sequencing technologies and workflows....

Winship authored publications for February 2016 (The Winship Cancer Institute of Emory University)

Edit Public Technologies 04 Mar 2016
(Source. The Winship Cancer Institute of Emory University). Various first authors and senior authors from Winship Cancer Institute have published 76 studies in major medical and scientific journals in the past month ... Authors' Reply to Gandjour ... Thorpe KE, Allen L, Joski P ... 2016; PubMed PMID ... Autosomal Dominant Retinal Dystrophies Caused by a Founder Splice Site Mutation, c.828+3A>T, in PRPH2 and Protein Haplotypes in trans as Modifiers....

Why Did Ancient Europeans Just Disappear 14,500 Years Ago?

Edit Yahoo Daily News 02 Mar 2016
The finds come from an analysis of dozens of ancient fossil remains collected across Europe ... A twisted family tree ... Nowadays, everyone of European descent has the N mitochondrial haplotype, while the M subtype is common throughout Asia and Australasia ... The M haplotype carried by the ancient Europeans, which no longer exists in Europe today, shared a common ancestor with modern-day M-haplotype carriers around 50,000 years ago ... In Images....
×
×
×
×