Buserelin

Buserelin

Clinical data
Trade names	Etilamide
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	X
Legal status	℞-only
Routes	implant, intranasal
Pharmacokinetic data
Half-life	72 to 80 minutes
Excretion	Renal
Identifiers
CAS number	57982-77-1 Y
ATC code	L02AE01 QH01CA90
PubChem	CID 50225
DrugBank	DB06719
ChemSpider	45545 Y
UNII	PXW8U3YXDV Y
ChEMBL	CHEMBL1909304
Synonyms	D-Ser(Tbu)6EA10LHRH
Chemical data
Formula	C62H90N16O15
Mol. mass	1299.48 g/mol
InChI InChI=1S/C60H86N16O13/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65)/t40-,41-,42-,43-,44-,45-,46-,47+,48-/m0/s1 Y Key:CUWODFFVMXJOKD-UVLQAERKSA-N Y
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Buserelin is a Gonadotropin-releasing hormone agonist (GnRH agonist). By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). It is 70 times more potent and longer acting than natural gonadotropin releasing hormone. Like other GnRH agonists, buserelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction.

It is normally delivered via a nasal spray but is also available as an injection.

Buserelin acetate is marketed by Sanofi-Aventis under the brand name Suprefact and a generic form of Buserelin is now produced by CinnaGen under the brand name CinnaFact.

Buserelin is also marketed under the brand name Metrelef. Metrelef is approved to treat patients with endometriosis by suppression of ovarian hormone production. In ovulation induction Metrelef is used as a pituitary blockade as an adjunct to gonadotrophin administration.